DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and si:dkey-43k4.5

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_017212096.1	Gene:	si:dkey-43k4.5 / 100148290	ZFINID:	ZDB-GENE-120215-82	Length:	487	Species:	Danio rerio

Alignment Length:	498	Identity:	151/498 - (30%)
Similarity:	244/498 - (48%)	Gaps:	78/498 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DEKLLINVSGRRFETWRNTLEKYPDTLLG-----SNEREFF-----YDEDCKEYFFDRDPDIFRH 94
            |..|.|||.|.|.....:.|:|:|||.||     .:|.:..     :|...||::|||:|.:|.:
Zfish    15 DHLLHINVGGLRNTLCSSILKKFPDTRLGQLLSCDSEDDILQLCDDFDVQRKEFYFDRNPGLFPY 79

  Fly    95 ILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDK------- 152
            :|::|:|||||..:..|:.|:.:|:.::||....:..||...|.|||.|...:..|::
Zfish    80 VLHFYQTGKLHIMEELCIFSFSQEIEYWGISDFFLDSCCSYRYLDRKLERHHKSWDEESDVSSVD 144

  Fly   153 --LSENGDQNL-------QQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVP 208
              :.|..|.|.       .:..|:|:.:|...|||..|..:.:|..::...:.:|:....:.::|
Zfish   145 TSVDEISDLNKDIEHFHEMRFGNIRKCLWLTLENPGYSIPSKLFSLLSICVVLISIATMCINSIP 209

  Fly   209 CGHRPGRAGTL---PCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAI 270
            ...:....|.|   |       ....|:..|:..||.|.:.|:..||:..||....:::||::::
Zfish   210 EYQKFDENGNLIEDP-------TMHVLEVFCICWFTFEVVTRMLLAPNHRKFFLLPLNVIDIISV 267

  Fly   271 MPYYIG------LGITDNDDVSGAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLV 328
            ||.||.      :|........|..| .||:.|:||:.|.:|||.|||.||.||:....|:|.|:
Zfish   268 MPIYITIFFDMLIGSESELGNLGKLVQVLRLMRIFRVLKLARHSTGLRSLGATLRHSYREVGILL 332

  Fly   329 FSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLS 393
            ..||:.:.:|:. |.|..:|.......:|||.:|:..|:|||:||||:||.|:|||:....|.|.
Zfish   333 LYLAVGVSVFSG-MAYTAENEEDVGLDTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILG 396

  Fly   394 GVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARWAAQ 458
            |.||:|||:.:|.:.||..|.          ::||..|.:|   .::...||.:::....
Zfish   397 GTLVVALPITIIFNKFSHFYR----------KQKALEASVR---NNNNKKFVMRQQRNSG----- 443

  Fly   459 ESGIE-----LDDNYRDEDI--------FELQHHHL---LRCL 485
            :|.|.     |:|...|||:        |..:.|.|   :||:
Zfish   444 DSAIHGHIHCLEDEEMDEDVDFDTGVVNFCYEDHPLTYTVRCV 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	41/113 (36%)
		Ion_trans	188..415	CDD:395416	79/236 (33%)
		DUF3399	445..540	CDD:403174	13/57 (23%)
si:dkey-43k4.5	XP_017212096.1	BTB_2	20..117	CDD:308049	33/96 (34%)
si:dkey-43k4.5	XP_017212096.1	Ion_trans	185..420	CDD:306908	80/252 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810