DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shal and kcnq1

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_002936545.2	Gene:	kcnq1 / 100145329	XenbaseID:	XB-GENE-5921462	Length:	659	Species:	Xenopus tropicalis

Alignment Length:	386	Identity:	93/386 - (24%)
Similarity:	163/386 - (42%)	Gaps:	86/386 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 MDDKLS-ENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHR 212
            :|.::| .:|.:.|...||::.:::...|.| |.....|:::.....:.:.::.:|:.|:
Frog    84 LDPRVSIYSGRRPLLTRTNIQGRVYNFLERP-TGWKCFVYHFTVFLIVLICLIFSVLSTI----- 142

  Fly   213 PGRAGTLPCGERYKIV----FFCLDTACVMIFTAEYLLRLFAAPDRCKFV---------RSVMSI 264
                      ::|..:    .|.::...|:.|.|||::||::|..|.|:|         |..:|:
Frog   143 ----------QQYNNLATETLFWMEIVLVVFFGAEYVVRLWSAGCRSKYVGIWGRLRFARKPISV 197

  Fly   265 IDVVAIMPYYIGLGITDNDDV--SGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL--- 324
            ||::.::...|.|.:..|..|  :.|...:|..::.|:....|.....|:||..:.....||
Frog   198 IDLIVVVASIIVLCVGSNGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITT 262

  Fly   325 ---GFLVFSLAMAIIIFATVMFY-AEKNVNGTN----FTSIPAAFWYTIVTMTTLGYGDMVPETI 381
               |||.       :||::...| |||:...::    |.|...|.|:.:||:||:||||.||:|.
Frog   263 LYIGFLG-------LIFSSYFVYLAEKDAIDSSGEYQFGSYADALWWGVVTVTTIGYGDKVPQTW 320

  Fly   382 AGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVS 446
            .||.:....|:..:...|||..::.|.|:....|.||......|..|..:.|:.|.....|
Frog   321 IGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAA---- 381

  Fly   447 KKKAAEARWAAQESGIELDDNYRDEDIF---ELQHHHLLRCLEK------------TTDRE 492
             :....|.|                .|:   :.::||:|....|            .||||
Frog   382 -ENPDSATW----------------KIYIRKQSRNHHILSPSPKPKKSAMVKKKKIRTDRE 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727
		Ion_trans	188..415	CDD:395416	64/252 (25%)
		DUF3399	445..540	CDD:403174	11/63 (17%)
kcnq1	XP_002936545.2	Ion_trans	120..356	CDD:366146	66/257 (26%)
kcnq1	XP_002936545.2	KCNQ_channel	<507..608	CDD:367540
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910