Protein Alignment Shal and kcnd3

DIOPT Version :10

• Sequence 1: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_001096411.1
• Gene: kcnd3 / 100125015
• XenbaseID: XB-GENE-5867971
• Length: 653
• Species: Xenopus tropicalis
• Alignment Length: 564
• Identity: 379/564 - (67%)
• Similarity: 436/564 - (77%)
• Gaps: 46/564 - (8%)

  Fly     1 MAS-VAAWLPFARAAAIGWVPIATHPLPPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPD 64
            ||| |||||||||||||||:|:|..|:|..|..|::|:  ||.:::|||||||:|||.|||:|||
 Frog     1 MASGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQ--DEVIILNVSGRRFQTWRTTLERYPD 63

  Fly    65 TLLGSNEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVI 129
            |||||.|:|||::|:.|||||||||::||.|||:|||||||||::||:::|||||||:||:|::|
 Frog    64 TLLGSTEKEFFFNEETKEYFFDRDPEVFRCILNFYRTGKLHYPRYECISAYDEELAFYGILPEII 128

  Fly   130 GDCCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFF 194
            ||||||:|:|||||||||||||...||..:.:..|| :||.||||||||||||.|||||||||||
 Frog   129 GDCCYEEYKDRKRENAERLMDDNEFENNQEAMPSLT-LRQTMWRAFENPHTSTLALVFYYVTGFF 192

  Fly   195 IAVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVR 259
            |||||:.|||||||||..||.. .|||||||.:.|||||||||||||.||||||||||.|.:|:|
 Frog   193 IAVSVITNVVETVPCGTVPGNK-ELPCGERYDVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFMR 256

  Fly   260 SVMSIIDVVAIMPYYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL 324
            ||||||||||||||||||.:|:|:|||||||||||||||||||||||||||||||||||||||||
 Frog   257 SVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL 321

  Fly   325 GFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGV 389
            |||:|||.|||||||||||||||..:.:.||||||:||||||||||||||||||:||||||.|.:
 Frog   322 GFLLFSLTMAIIIFATVMFYAEKGSSSSKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSI 386

  Fly   390 CSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKK----- 449
            |||||||||||||||||||||||||||||||||:||:||||||||:||..|..|::..|:
 Frog   387 CSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSTAYLHSKRNGLLN 451

  Fly   450 -AAEARWAAQESGIELDDNYRDEDIFELQHHHLLRCLEKTT------------------------ 489
             |.|...:.:|..|.     :...:.|.||||||.||||||
 Frog   452 EALELMGSTEEPHIG-----KSASLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTMKNHEFM 511

  Fly   490 DREFVELEIPFNGQPKRPGSPSPMASPAHSTNSAAGLLQSCCGR 533
            |.:..|.....:.....|.|.||..|..|      ||..|||.|
 Frog   512 DEQMFEQNCRESSMQNYPSSRSPSLSSNH------GLTTSCCSR 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	95/137 (69%)
		Ion_trans	188..415	CDD:459842	193/226 (85%)
		DUF3399	471..535	CDD:463381	27/87 (31%)
kcnd3	NP_001096411.1	BTB_POZ_KCND3	6..143	CDD:349726	96/138 (70%)
		Ion_trans	186..412	CDD:459842	193/226 (85%)
		DUF3399	468..563	CDD:463381	27/88 (31%)