DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ltn1 and Ltn1

DIOPT Version :9

Sequence 1:	NP_730427.1	Gene:	Ltn1 / 40127	FlyBaseID:	FBgn0262517	Length:	1747	Species:	Drosophila melanogaster
Sequence 2:	NP_001074537.1	Gene:	Ltn1 / 78913	MGIID:	1926163	Length:	1767	Species:	Mus musculus

Alignment Length:	1938	Identity:	512/1938 - (26%)
Similarity:	844/1938 - (43%)	Gaps:	363/1938 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGGKTKQAPRTKNNAKPSSSSRTAELLG---SSTPIFVGFSAQTDGGGLVPFAPGFASAEQMPDS 62
            ||||.||  |||.|.:||:|.|.||||.   .:.|.|:||.......|.||       |.|..:.
Mouse     1 MGGKNKQ--RTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSHSDLGYVP-------AVQGAED 56

  Fly    63 FDAAISPQTQIILRKLSKKDPMTKKKALQELHELIEQSDVEVLKNILPLWPKYYLNLASDPEHTV 127
            .|:.:....:::||||||||..||.||:||...:..:.|.|.:|.:||.||:.:..::.|.:..|
Mouse    57 IDSLVDSDFRMVLRKLSKKDVTTKLKAMQEFGIMCTERDTEAVKGVLPYWPRIFCKISLDHDRRV 121

  Fly   128 REQTQTVLQLLMAKCKKAMAPYLKLLVPVWLGSRFDTYAPAASIASQSFRDTFAGNANRSREVCM 192
            ||.||...:.|:.|.||.:|||||.::..||.::.|||.|||..|..:|...|.  .::..|...
Mouse   122 REATQQAFEKLILKVKKHLAPYLKSVMGYWLMAQCDTYPPAALAAKDAFEAAFP--PSKQPEAIA 184

  Fly   193 HCQVEILEYATRNLTFHTAATLSIGKSLTPEDAEQKYQRVIISSL----KLLSFFMGQTAQTEEL 253
            .|:.||......:|...|..|||..:::..|:.|.|:.||:..||    :||.|.     ...||
Mouse   185 FCKEEITTVLQDHLLKETPDTLSDPQTVPEEEREAKFHRVVTCSLLALKRLLCFL-----PNNEL 244

  Fly   254 SQVKEGFGTLVAHQKFWSFAKHKVPAIKAAWFECIYHILQSVALLDVITPQKTQLTNLCFQFIDD 318
            ..::|.|.:|::..|||.:.||.||.:::|:||.:..:.|.|.  .|:..:..:::......|||
Mouse   245 DSLEEKFKSLLSQNKFWKYGKHSVPQVRSAYFELVSALCQHVP--QVMKEEAAKVSPSVLLSIDD 307

  Fly   319 ADPVVAPHIWGCVLLLQSNYVDWFVPLNIRKTLLPKLSSLLQNGFNRNAQAICPNLLPFLSKVTQ 383
            :||||.|.:|..||...:...|.:..:|.:|::.|||.::::.|....|..:.|.||||:||:.|
Mouse   308 SDPVVCPALWEAVLYTLTTIEDCWFHVNAKKSVFPKLMAMIREGGRGLAAVMYPYLLPFISKLPQ 372

  Fly   384 ASLQDLDIYDFYQRFFDDMKLAV----TKKFDPPLSKSDCIVIHNAYFECLRFLMQQINNNKQRE 444
            :..:..  .||::.|...:...:    ||.     |.|:|..:.:|:||||||:|||       .
Mouse   373 SITEPK--LDFFKNFLTSLVTGLSTERTKS-----SSSECSAVISAFFECLRFIMQQ-------N 423

  Fly   445 QKEEEFSFSLLDNNVLEPIAWLLKSDSTHVKIFFQHSSALVAFWDRQINNRLDNGDLY--AKLLN 507
            ..|||....|::..::..|..:||....|....|.|.:..::.|:.:.:...|.|.:|  ..:|.
Mouse   424 LGEEEMVQMLINEQLIPFIDTVLKDSGLHHGPMFDHLADTLSSWEAKADAERDPGAVYNLENVLL 488

  Fly   508 KFWIRIFELVTQDLSAEEVNEQLLGHVLLLVQDLHMANPSL-----ESPSVKFV----------- 556
            .||.|:.|:.|:.:...|.:.:.:..|..||..|.....||     ::..|:|.
Mouse   489 SFWGRLSEICTEKIRQPEADVKSVLCVSSLVGVLQRPRSSLKLHRKKTAQVRFAINIPEAHKGDE 553

  Fly   557 -----EGPNEKIEKSEPTTPVKKAQE--AAAFIQKELKQLVIKLVRICLDKANKGSGSGTSSSRY 614
                 ||.|.:.......:|:.....  .:...:|.|:.||.||..:.:...|:     ..|.::
Mouse   554 KSMSSEGENSEGSDGGAQSPLSNTSSDLVSPLRKKPLEDLVCKLAEVSISFVNE-----RKSEQH 613

  Fly   615 IEQIRTLTKMFNDAAFYKSLTDDGD----LASALN-----------KFV--SLLGQLSCQACES- 661
            ::.:.||...|:....:..|..|..    .|..|.           ||:  .|:|.|:....|.
Mouse   614 LQFLSTLLDSFSSVQVFNILLSDKQKNVVKAKPLEITKLAEKNPAVKFLYHKLIGWLNDSQKEDG 678

  Fly   662 --VVEIVFEILPLLETGKRFEYIENTLMKLPQHGVQNLLLHRLLSY--PLCA----EAAVRQMLS 718
              :|:|::..|...::|...:.:.:.|.|      ::|....||..  ..|:    .|.|...|.
Mouse   679 GFLVDILYSALRCCDSGVERKEVLDDLTK------EDLKWSSLLQVIEKACSSSDKHALVTPWLK 737

  Fly   719 GPETCEMIARIAEEVVVDND----------REKLNLLHKCFFQTDTGDILINAKTVDKILLSMCG 773
            |....|.:..:| :.:.|.|          .|:.:||.....|....|.||....|.:|::.:..
Mouse   738 GSILGEKLVALA-DCLCDKDLEATTSESHSSEQWSLLRLALSQHVKNDYLIGEVYVGRIIVKLHE 801

  Fly   774 PLEQPVVDDAVEVCG-----SFIAQIMPVICSNNNSSLHV--RQHIFLKLFKFSLEHRPEDYLSE 831
            .|.:  ..|..|...     ||:..::....|:....|.:  .:.:.|.||:...:.:...:|.:
Mouse   802 TLSK--TKDLSEAANSDSSVSFVCDVVHSFFSSAGGGLLMPPSEDLLLTLFQLCAQSKERTHLPD 864

  Fly   832 DTLWEITTCWQDGLSSKDIEIDDDMLKCCAGIVEELANSAELKADTLDGMAEAMAKFVICSTENI 896
            ..:.::......|::.               :|.:.|::.|            .:.|:..|...:
Mouse   865 FLICKLKNTLLSGVNL---------------LVHQTASTYE------------QSTFLRLSVLWL 902

  Fly   897 EDEYKRLERIDET-----LTA---LLETPLKTTDKVQQFENHCVLLEALHGSVTAGVPFENACLS 953
            :|:.:. ..:|.|     |:|   ||.|.:::.|        ..||....|||   :|.::....
Mouse   903 KDQVQS-SALDNTSLQVLLSAAGDLLGTLVESED--------TSLLGVYIGSV---MPSDSEWEK 955

  Fly   954 RNEIL-------PLLQ-RSTLN---FSTIYKLVYQFPPPQDTND-PEDELTEDYCDPNADVLKKW 1006
            ..:.|       |||: |.:||   |.|.:|       .|||.. |....|.........|.:|.
Mouse   956 MRQALPVQWLHRPLLEGRLSLNYECFKTDFK-------EQDTKTLPNHLCTSSLLSKMILVAQKK 1013

  Fly  1007 N--------EPLIAELLQCIRVAGTAECWLE------------MSVLQ--SSTEELVLILSEKVQ 1049
            .        |.:|||||..::       |.|            ..:||  :.|...:.:|||
Mouse  1014 KLVLEDNVLEKIIAELLYSLQ-------WCEELDNAPSFLSGFCGILQKMNITYSNLSVLSE--- 1068

  Fly  1050 SFMGNSSDLVAIVKERLQQAAVQQSSVIDCRLLSYLRFCPQYAAFEESASILLHEDLSENLV--- 1111
                 :|.|:.::.:|.::.....|.:|                    |.::|...:|.:.|
Mouse  1069 -----TSSLLQLLFDRSRKNGTLWSLII--------------------AKLILSRSISSDEVKPY 1108

  Fly  1112 ----------TQGALKTYVIALQFLLPKLSQK-----AITLSSAIMGTEPPEIWVK--------- 1152
                      |:|:|.|    :|.|.|.||::     :.....|.:|      |.|
Mouse  1109 YKRKESFFPLTEGSLHT----IQSLCPFLSKEEKKEFSAQCIPAFLG------WTKEDLCSINGA 1163

  Fly  1153 ---AAVFHALLLNNFEGDVNEQT----DRNIIVSAVQFMTSIGERQASQKDLLHYNVEIQRQPYE 1210
               .|:|::.|          ||    |:.::...::.:||   .:...:|:..::..:.....|
Mouse  1164 FGHLAIFNSCL----------QTRSIDDKQLLHGILKIITS---WRKQHEDIFLFSCNLSEASPE 1215

  Fly  1211 SVINTVEFIKLLTEVLKR--FPYELSIKNWDAIRIGLSSWVLSVSKSIAQYQDPKTSLFIVAVYE 1273
            .:...:|.::.|:..||.  :|..|:...||.|...:.:|:.:.|::.|.|..|...||....::
Mouse  1216 VLGLNIEIMRFLSLFLKHCAYPLPLADSEWDFIMCSMLAWLETTSENQALYSVPLVQLFACVSFD 1280

  Fly  1274 LFAALIDFIRSEKQKSSTELLKNMIDEWDSLFAKEVNLVLFKSYYLLTHEVS-----VDPGFQAC 1333
            |...|..|..|........|..|:|.||...|:|.::.:|..   ||.:.:.     .:..||
Mouse  1281 LACDLCAFFDSITPDIVDNLPVNLISEWKEFFSKGIHSLLLP---LLVNAIGENKDLSETSFQ-- 1340

  Fly  1334 YEALLEQITPVIERLDY------------SFVYSFCKSNSNITLDHLCNFLFKQLYSVQHSVRLS 1386
             .|:|:   |:.|.|.|            :.:.:..|:|....|..|.|.|...|......|:::
Mouse  1341 -NAMLK---PMCETLTYISKDQLLSHKLPARLVASQKTNLPEHLQTLLNTLTPLLLFRARPVQIA 1401

  Fly  1387 AVHSLRQLTPHFVADDIEL-----NEKQSESLDASTTICKWHFLNRFEDYLTRYDALITKYLEEF 1446
            |.|.|.:|.|.....|.:.     :|::..:|.....:.         ..|:..:.|:...|.
Mouse  1402 AYHMLCKLMPELPQHDQDNLRSYGDEEEEPALSPPAALM---------SLLSSQEELLENVLG-- 1455

  Fly  1447 TFKLSELDDLEPI--DRHNALSYLFLWDCIINACAKSPVALRAVYTNWLNDNKYEENFLHFLFRA 1509
            ...:.::..::|:  |....|.||..|..|:.....:...|||:|:.:|...|.....|:.|||.
Mouse  1456 CVPVGQIVTVKPLSEDFCYVLGYLLTWKLILTFFKAASSQLRALYSMYLRKTKSLNKLLYHLFRL 1520

  Fly  1510 MP---------VDILKNHGAKVHSNGVYKELTWSQQKDRHLPLERYACHLYTEVLRKLPAVVRRW 1565
            ||         :::.........:..|...:..:.....|:|  ..||.:|...|:.|||:||.|
Mouse  1521 MPENPTYGETAIEVSSKDPKTFFTEEVQLSIRETATLPYHIP--HLACSVYHMTLKDLPAMVRLW 1583

  Fly  1566 WNATQSRQKNFIDNLTTNYVSSLICSEELKAIANRKEKHENMQVTVHSSTREVLAVYAIDEARME 1630
            ||:::.|..|.:|..|:.|||:::..:|:.::....:....|.|...::||||:|.|.|::..:|
Mouse  1584 WNSSEKRVFNIVDRFTSKYVSNVLSFQEISSVQTSTQLFNGMTVKARATTREVMATYTIEDIVIE 1648

  Fly  1631 LVITLAPNYPLGAVKVECGKQIGGRASS-RNVGMQLTIFLTHQNGTIYDGLTMWKNNLDKKFEGV 1694
            |:|.|..|||||::.||.||:||..... ||..:||:.:||||||:|.:||.:||||:||:||||
Mouse  1649 LIIQLPSNYPLGSITVESGKRIGVAVQQWRNWMLQLSTYLTHQNGSIMEGLALWKNNVDKRFEGV 1713

  Fly  1695 EECYVCYTVIHQETCQLPKLTCKTCKKKFHGPCLYKWFTTSSKSTCPICRNVF 1747
            |:|.:|::|||.....|||..|:|||||||..|||||||:|:|||||:||..|
Mouse  1714 EDCMICFSVIHGFNYSLPKKACRTCKKKFHSACLYKWFTSSNKSTCPLCRETF 1766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ltn1	NP_730427.1	RING	<1724..1744	CDD:302633	14/19 (74%)
Ltn1	NP_001074537.1	HEAT 1. /evidence=ECO:0000255	59..96		15/36 (42%)
		HEAT 2. /evidence=ECO:0000255	100..138		13/37 (35%)
		HEAT 3. /evidence=ECO:0000255	273..314		10/40 (25%)
		HEAT 4. /evidence=ECO:0000255	335..372		8/36 (22%)
		HEAT 5. /evidence=ECO:0000255	380..418		8/41 (20%)
		HEAT 6. /evidence=ECO:0000255	433..473		10/39 (26%)
		HEAT 7. /evidence=ECO:0000255	509..547		10/37 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..583		6/50 (12%)
		HEAT 8. /evidence=ECO:0000255	621..658		11/53 (21%)
		HEAT 9. /evidence=ECO:0000255	676..714		8/43 (19%)
		HEAT 10. /evidence=ECO:0000255	1067..1104		4/36 (11%)
		HEAT 11. /evidence=ECO:0000255	1183..1226		6/42 (14%)
		HEAT 12. /evidence=ECO:0000255	1315..1353		10/54 (19%)
		HEAT 13. /evidence=ECO:0000255	1378..1415		9/41 (22%)
		HEAT 14. /evidence=ECO:0000255	1476..1513		12/45 (27%)
		zf-RING_2	1714..1763	CDD:290367	24/34 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848493
Domainoid	1	1.000	489	1.000	Domainoid score	I376
eggNOG	1	0.900	-	-		E1_COG5219
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	568	1.000	Inparanoid score	I1065
Isobase	1	0.950	-	0	Normalized mean entropy	S6253
OMA	1	1.010	-	-		QHG55728
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004053
OrthoInspector	1	1.000	-	-		oto93693
orthoMCL	1	0.900	-	-		OOG6_106539
Panther	1	1.100	-	-	LDO	PTHR12389
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R672
SonicParanoid	1	1.000	-	-		X2799
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.740