DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ltn1 and ltn1

DIOPT Version :9

Sequence 1:	NP_730427.1	Gene:	Ltn1 / 40127	FlyBaseID:	FBgn0262517	Length:	1747	Species:	Drosophila melanogaster
Sequence 2:	XP_012812767.1	Gene:	ltn1 / 780202	XenbaseID:	XB-GENE-1217544	Length:	1779	Species:	Xenopus tropicalis

Alignment Length:	1915	Identity:	503/1915 - (26%)
Similarity:	856/1915 - (44%)	Gaps:	305/1915 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGGKTKQAPRTKNNAKPSSSSRTAELLGSST---PIFVGF-SAQTDGGGLVPFAPGFASAEQMPD 61
            ||||.||  |||.||:||||.|.||||...:   |.|:|| |:|:|..    :.|....||::
Frog     1 MGGKNKQ--RTKGNARPSSSGRAAELLAKESGTIPGFIGFGSSQSDHS----YVPAVQGAEEV-- 57

  Fly    62 SFDAAISPQTQIILRKLSKKDPMTKKKALQELHELIEQSDVEVLKNILPLWPKYYLNLASDPEHT 126
              |:.:....:::||||||:|.:||.||:||...:.::.::|.::.:||.||:.|..::.|.:..
Frog    58 --DSLVDADFRLVLRKLSKRDAITKLKAMQEFGFMCKEREMETVRGVLPYWPRIYCKISLDLDRR 120

  Fly   127 VREQTQTVLQLLMAKCKKAMAPYLKLLVPVWLGSRFDTYAPAASIASQSFRDTFAGNANRSREVC 191
            |||.||...:.|:.|.||.:||:||.|:..||.::.|||:||||.|..:|...|.  |::..|..
Frog   121 VREATQQAFEQLILKVKKYLAPHLKSLMGFWLIAQCDTYSPAASSARVAFEAAFP--AHKQPEAL 183

  Fly   192 MHCQVEILEYATRNLTFHTAATLSIGKSLTPEDAEQKYQRVIISSLKLLSFFMGQTAQTEELSQV 256
            ..|:.||:.....:|...|..|||..:::..||.|.||.||:..||..|...:....::|. |.:
Frog   184 AFCKEEIMNVLLDHLLKETPDTLSDTQAVPIEDRESKYFRVVTCSLLALKRLLCMLPRSEN-SSL 247

  Fly   257 KEGFGTLVAHQKFWSFAKHKVPAIKAAWFECIYHILQSVALLDVITPQKTQLTNLCFQFIDDADP 321
            :|....|::..|||.::||...:|::|:||.:..:.|...  ||:..:.::|.......|||:|.
Frog   248 QERLAHLLSQSKFWKYSKHSTSSIRSAFFELMSALCQCSP--DVLRAEASRLCPAVLLSIDDSDA 310

  Fly   322 VVAPHIWGCVLLLQSNYVDWFVPLNIRKTLLPKLSSLLQNGFNRNAQAICPNLLPFLSKVTQASL 386
            ||.|.:|..||...:...|.:..:|.:|.:||||.|:|:.|....|..|.||||||:|:|....:
Frog   311 VVCPALWEAVLYTITTIEDCWEHVNAQKGVLPKLWSVLREGGRGLATVIFPNLLPFISRVPTNII 375

  Fly   387 QDLDIYDFYQRFFDDMKLAVTKKFDPPLSKSDCIVIHNAYFECLRFLMQQINNNKQREQKEEEFS 451
            :...  |||..||:.:...::.: ....|.::|..|.:||.|||||.||:....::..:|.::..
Frog   376 KTPT--DFYSNFFNSLGQGLSSE-RAVASPAECSAIISAYMECLRFAMQENAGEEEENKKVQQIL 437

  Fly   452 FS-----LLDNNVLEPIAWLLKSDSTHVKIFFQHSSALVAFWDRQINNR-LDN--GDLYAKLLNK 508
            .|     |:|:::.:|     |..::  .:|.|....|.: |:::..:: ||:  ..::|.||.:
Frog   438 ISDQLMPLIDSSLKDP-----KLQNS--PLFSQVEETLYS-WEKKAESQGLDDKLSRIHATLLRE 494

  Fly   509 FWIRIFELVTQDLSAEEVNEQLLGHVLLLVQDLHMANPSL-----ESPSVKFVEGPNEKIEKSEP 568
            ||..:..:....:...|..|:.|..|..|:|.|...|..|     :...::|   ..|..::|:.
Frog   495 FWENLAHICVSHVDVIEAGEKNLAGVSGLLQVLQNPNCLLKVNKKKKAKIRF---KGEDDDESDA 556

  Fly   569 TTPVKKAQEAAAFI-----------------QKELKQLVIKLVRICLDKANKGSGSGTSSSRYIE 616
            .:.|.::|..:.||                 |:.|:.||.||..:.:...     |...|.:::.
Frog   557 VSHVSESQPMSKFIMETCSSSGRDPGIAQLRQERLEDLVCKLAELSMVYI-----SEQRSQQHLM 616

  Fly   617 QIRTLTKMFNDAAFYKSLTDDGDLASALN----------------------KFVSLLGQLSCQAC 659
            .:..|...|.....::.|..........|                      |.:......|.:..
Frog   617 FLAALLSTFPSIRVFQVLLQQSSEEDPKNLNSPDHDVTPRHKNPAVQFLYAKLIFWFNDKSLEES 681

  Fly   660 ESVVEIVFEIL----------PLLETGKRFEYIENTLMKLPQHGVQN--------------LLLH 700
            :.:|:|::.:|          .||:...:..:..:..:.:.|....:              :|..
Frog   682 DFLVDILYSVLFCCTDSSERKHLLDDMTKMNFKWSVFLYIIQKACTDPEKYSLASDWLKGEVLGE 746

  Fly   701 RL--LSYPLCAEAAVRQMLSGPETCE----MIARIAEE------VVVDNDREK-LNLLHKCFFQT 752
            ||  |:..||....:.:.......|.    :::.:..|      ::.|...|| :|.||..
Frog   747 RLICLANDLCTSGLMDKATPSEAYCSKKWALLSLVLSEHVHNEYLIADAYVEKIINKLHSA---- 807

  Fly   753 DTGDILINAKTVDKILLSMCGPLEQPVVDDAVEVCGSFIAQIMPVICSNNNSSLHV--RQHIFLK 815
                 |:.|:.     ||..|.|||.|         |||..:.....|:....|.:  .:.:.|.
Frog   808 -----LMKARN-----LSKAGHLEQSV---------SFICDVGSNFFSSIKGCLQMPSAEDLLLT 853

  Fly   816 LFKFSLEHRPEDYLSEDTLWEITTCWQDGLSS-----KDIEIDDDMLKCCAGIVEELANSAELKA 875
            :|:...:.....::||..|.::...|..||.|     |::....:.||..|..|::...::.|..
Frog   854 IFQLCAQASDTSHMSESLLLKLKNTWLAGLHSLVCQYKNMPQGSNFLKQSAQWVKDQIQTSHLNV 918

  Fly   876 DTLDGMAEAMAKFVICSTENIEDEYKRLERIDETLTALLETPLKTTDKVQQFENHCVLLEALHGS 940
            .:|..:        ||:   ::|.|..:  :|.:|:........|...:...|....:..||
Frog   919 KSLQSL--------ICT---VDDLYSTI--LDSSLSGFSLLAEHTASMMPSAETWQKMRHAL--- 967

  Fly   941 VTAGVPFENACLSRNEILPLLQ-RSTLNFSTIYKLVYQFPPPQDTNDPEDELTEDYCDPNADVLK 1004
                   .:..||:    |||: |.::|..|....:..|        |:..|....|  .|.:|.
Frog   968 -------SSQWLSK----PLLEGRLSMNTETSGTDLKSF--------PKTWLPSHLC--TASLLS 1011

  Fly  1005 KWNEPLIAELLQCIRVAGTAECWLEMSVLQSS-------TEELVLILSEKVQSFMGNSSDL---V 1059
            |    :...||:..:.....|..:::::..:.       .|||     ||..:.:|...::   :
Frog  1012 K----MALRLLEKEKSLKEEEIGVKINITVAEMLYSLQWCEEL-----EKPPTLIGECCEMLCSL 1067

  Fly  1060 AIVKERLQQAAVQQSSVIDCRLLSYLRFCPQYAAFEESASILLHE---------DLSENL----- 1110
            .:..|::...:|....:::   |.|.|.....:.:..:|:..:|:         .|:|:.
Frog  1068 GVSHEKVMDLSVHLPGLLE---LLYNRSKEDGSLWSLTANRFIHKRGAGPSELLPLTEDTEKYFP 1129

  Fly  1111 VTQGALKTYVIALQFLLPKLSQKAI--------TLS-SAIMGTEPPEIWVKAAVFHALLLNNFEG 1166
            ||.|:|.|......|:.|:|.::.:        |.| ||:..|:       ....:..::|:..|
Frog  1130 VTLGSLHTIQSLSAFMCPELKEELVIQCTARLMTCSASAVSCTD-------GGFGYLAIINSCLG 1187

  Fly  1167 DVNEQTDRNIIVSAVQFMTSIGERQASQKDLLHYNVEIQRQPYESVINTVEFIKLLTEVLKRFPY 1231
            . :....:.|:...::.|.|..:   .|:|:..::..:|......:...||.|:.|:.:||....
Frog  1188 S-DSDLCQEILPGVLKVMLSWKD---DQEDIFLFSSNVQDSSQSLIGLNVEMIRFLSILLKYLAS 1248

  Fly  1232 ELSI---KNWDAIRIGLSSWVLSVSKSIAQYQDPKTSLFIVAVYELFAALIDFIRSEKQKSSTEL 1293
            .:|.   .:||.|...:.:|:.|..:|.|.|..|...||..|..:|...:..:..|....::..|
Frog  1249 SVSSLVDVDWDFIMCSMLAWLESACESSAAYHIPLVRLFACASCDLATEISHYFESVATSTTMSL 1313

  Fly  1294 LKNMIDEWDSLFAKEVNLVLFKSYYLLTHEVSVDPGFQACYEALLEQITPVIER----------L 1348
            ..|::.||...|::.:..::......:..|      ::|...:.:..:...:.|          |
Frog  1314 PANLMSEWKEFFSEGIYSLMLPMLVRIAEE------YKASETSHMSHVLKSLGRTLGYISKEQLL 1372

  Fly  1349 DYSFVYSFC---KSNSNITLDHLCNFLFKQLYSVQHSVRLSAVHSLRQL---TPHFVADDIELNE 1407
            ::.....|.   |:|...:|..|.|.|...|...:.||:::..|.|.::   .|.|..:|::...
Frog  1373 NHKLPAKFVAGQKTNLTDSLQSLLNTLAPLLLYRERSVQITVYHLLDKIMADLPGFDDEDLKSYG 1437

  Fly  1408 KQSESLDASTTICKWHFLNRFEDYLTRYDALITKYLEEFTFKLSELDDLEPIDRH--NALSYLFL 1470
            .:.|....|........|...||       |:...|:|  ..:.|...:||:...  ..|.||..
Frog  1438 DEDEEPALSPPAALMSVLAIQED-------LVESILKE--IPVGEFAVIEPLKEEFCFVLGYLLT 1493

  Fly  1471 WDCIINACAKSPVALRAVYTNWLNDNKYEENFLHFLFRAMPVD-ILKNHGAKVHSNG-------- 1526
            |..|:.....:...|||:|:.:|...|.....|:.||:.||.: :|....:.:.|..
Frog  1494 WKLILTFFKAASSQLRALYSQYLRKTKSLNKLLYNLFKLMPHNPVLPGQASDMPSKEPKTFFTEE 1558

  Fly  1527 ---VYKELTWSQQKDRHLPLERYACHLYTEVLRKLPAVVRRWWNATQSRQKNFIDNLTTNYVSSL 1588
               ..|.....||:..||     ||.:|...|:.|||:||.|||..:.|..|.:|..||.||||:
Frog  1559 LQLAVKGTATVQQEVPHL-----ACCVYHMTLKDLPAMVRLWWNGCEKRIFNVVDRFTTKYVSSV 1618

  Fly  1589 ICSEELKAIANRKEKHENMQVTVHSSTREVLAVYAIDEARMELVITLAPNYPLGAVKVECGKQIG 1653
            :.|:|:.::....:..:.|.|...|:||||:|.|::|:..:||:|.|..|||||::.||.|:::|
Frog  1619 LSSQEISSVQLSTQVFDGMTVKARSTTREVIATYSVDDICIELIIQLPQNYPLGSITVESGRRVG 1683

  Fly  1654 GRASS-RNVGMQLTIFLTHQNGTIYDGLTMWKNNLDKKFEGVEECYVCYTVIHQETCQLPKLTCK 1717
            ..... ||..:||..:||||||:|.:||.:||||:||:|||||:|.:|::|||.....|||..|:
Frog  1684 VAVQQWRNWMLQLNTYLTHQNGSIMEGLALWKNNVDKRFEGVEDCMICFSVIHGSNYSLPKKACR 1748

  Fly  1718 TCKKKFHGPCLYKWFTTSSKSTCPICRNVF 1747
            |||||||..|||||||:|:|||||:||..|
Frog  1749 TCKKKFHSECLYKWFTSSNKSTCPLCRETF 1778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ltn1	NP_730427.1	RING	<1724..1744	CDD:302633	14/19 (74%)
ltn1	XP_012812767.1	COG5219	59..>262	CDD:227544	72/205 (35%)
ltn1	XP_012812767.1	COG5219	<1490..1778	CDD:227544	123/292 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	459	1.000	Domainoid score	I484
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1154
OMA	1	1.010	-	-		QHG55728
OrthoDB	1	1.010	-	-		D19753at2759
OrthoFinder	1	1.000	-	-		FOG0004053
OrthoInspector	1	1.000	-	-		otm48610
Panther	1	1.100	-	-	LDO	PTHR12389
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R672
SonicParanoid	1	1.000	-	-		X2799
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110