DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ltn1 and LTN1

DIOPT Version :9

Sequence 1:	NP_730427.1	Gene:	Ltn1 / 40127	FlyBaseID:	FBgn0262517	Length:	1747	Species:	Drosophila melanogaster
Sequence 2:	NP_056380.3	Gene:	LTN1 / 26046	HGNCID:	13082	Length:	1766	Species:	Homo sapiens

Alignment Length:	1927	Identity:	516/1927 - (26%)
Similarity:	853/1927 - (44%)	Gaps:	342/1927 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGGKTKQAPRTKNNAKPSSSSRTAELLG---SSTPIFVGF-SAQTDGGGLVPFAPGFASAEQMPD 61
            ||||.||  |||.|.:||:|.|.||||.   .:.|.|:|| ::|:|.|    :.|....||::
Human     1 MGGKNKQ--RTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSQSDLG----YVPAIQGAEEI-- 57

  Fly    62 SFDAAISPQTQIILRKLSKKDPMTKKKALQELHELIEQSDVEVLKNILPLWPKYYLNLASDPEHT 126
              |:.:....:::||||||||..||.||:||...:..:.|.|.:|.:||.||:.:..::.|.:..
Human    58 --DSLVDSDFRMVLRKLSKKDVTTKLKAMQEFGTMCTERDTETVKGVLPYWPRIFCKISLDHDRR 120

  Fly   127 VREQTQTVLQLLMAKCKKAMAPYLKLLVPVWLGSRFDTYAPAASIASQSFRDTFAGNANRSREVC 191
            |||.||...:.|:.|.||.:|||||.|:..||.::.|||.|||..|..:|...|.  .::..|..
Human   121 VREATQQAFEKLILKVKKQLAPYLKSLMGYWLMAQCDTYTPAAFAAKDAFEAAFP--PSKQPEAI 183

  Fly   192 MHCQVEILEYATRNLTFHTAATLSIGKSLTPEDAEQKYQRVIISSL----KLLSFFMGQTAQTEE 252
            ..|:.||......:|...|..|||..:::..|:.|.|:.||:..||    :||...     ...|
Human   184 AFCKDEITSVLQDHLIKETPDTLSDPQTVPEEEREAKFYRVVTCSLLALKRLLCLL-----PDNE 243

  Fly   253 LSQVKEGFGTLVAHQKFWSFAKHKVPAIKAAWFECIYHILQSVALLDVITPQKTQLTNLCFQFID 317
            |..::|.|.:|::..|||.:.||.||.|::|:||.:..:.|.:..|  :..:.::::......||
Human   244 LDSLEEKFKSLLSQNKFWKYGKHSVPQIRSAYFELVSALCQRIPQL--MKEEASKVSPSVLLSID 306

  Fly   318 DADPVVAPHIWGCVLLLQSNYVDWFVPLNIRKTLLPKLSSLLQNGFNRNAQAICPNLLPFLSKVT 382
            |:||:|.|.:|..||...:...|.::.:|.:|::.||||::::.|....|..|.|.||||:||:.
Human   307 DSDPIVCPALWEAVLYTLTTIEDCWLHVNAKKSVFPKLSTVIREGGRGLATVIYPYLLPFISKLP 371

  Fly   383 QASLQDLDIYDFYQRFFDDMKLAVTKKFDPPLSKSDCIVIHNAYFECLRFLMQQINNNKQREQKE 447
            | |:.:..: ||::.|...:...::.:.....|.....|| :|:||||||:|||       ...|
Human   372 Q-SITNPKL-DFFKNFLTSLVAGLSTERTKTSSLESSAVI-SAFFECLRFIMQQ-------NLGE 426

  Fly   448 EEFSFSLLDNNVLEPIAWLLKSDSTHVKIFFQHSSALVAFWDRQINNRLDNGDLY--AKLLNKFW 510
            ||....|:::.::..|..:||.........|.|.:..::.|:.:.:...|....:  ..:|..||
Human   427 EEIEQMLVNDQLIPFIDAVLKDPGLQHGQLFNHLAETLSSWEAKADTEKDEKTAHNLENVLIHFW 491

  Fly   511 IRIFELVTQDLSAEEVN-EQLLGHVLLLVQDLHMANPSLESP-----SVKF-------------- 555
            .|:.|:....:|..|.: |.:|| |..|:|.|.....||:|.     .|:|
Human   492 ERLSEICVAKISEPEADVESVLG-VSNLLQVLQKPKSSLKSSKKKNGKVRFADEILESNKENEKC 555

  Fly   556 VEGPNEKIEKSEPTTPVKKAQEAAAFI----QKELKQLVIKLVRICLDKANKGSGSGTSSSRYIE 616
            |....||||..|.||.......::..:    :|.|:.||.||..|.::..|:     ..|.:::.
Human   556 VSSEGEKIEGWELTTEPSLTHNSSGLLSPLRKKPLEDLVCKLADISINYVNE-----RKSEQHLR 615

  Fly   617 QIRTLTKMFNDAAFYKSLTDDG----------DLASALNK-------FVSLLGQLSCQACES--- 661
            .:.||...|:.:..:|.|..|.          ::|..:.|       :..|:|.|:....:.
Human   616 FLSTLLDSFSSSRVFKMLLGDEKQSIVQAKPLEIAKLVQKNPAVQFLYQKLIGWLNEDQRKDFGF 680

  Fly   662 VVEIVFEIL----------PLLETGKRFEYIENTLMKLPQHGVQNLLLHRLLSYPLCAEAAVRQM 716
            :|:|::..|          .:|:...:.:...|:|:|:.:....:...|.|:: |......:.:.
Human   681 LVDILYSALRCCDNDMERKKVLDDLTKVDLKWNSLLKIIEKACPSSDKHALVT-PWLKGDILGEK 744

  Fly   717 LSGPETC----EMIARIAEEVVVDNDREKLNLLHKCFFQTDTGDILINAKTVDKILLSMCGPL-- 775
            |.....|    ::.:|::.|   .:..|:..||.....|....|.||....|::|::.:...|
Human   745 LVNLADCLCNEDLESRVSSE---SHFSERWTLLSLVLSQHVKNDYLIGDVYVERIIVRLHETLFK 806

  Fly   776 -----EQPVVDDAVEVCGSFIAQIMPVICSNNNSSLHV--RQHIFLKLFKFSLEHRPEDYLSEDT 833
                 |....|.:|    |||..:.....|:....|.:  .:.:.|.||:...:.:.:.:|.:..
Human   807 TKKLSEAESSDSSV----SFICDVAYNYFSSAKGCLLMPSSEDLLLTLFQLCAQSKEKTHLPDFL 867

  Fly   834 LWEITTCWQDGLSSKDIEIDDDMLKCCAGIVEELANSAELKADTLDGMAEAMAKFVICSTENIED 898
            :.::...|..|::....:.|....:.....:..|....:::|.:||                |..
Human   868 ICKLKNTWLSGVNLLVHQTDSSYKESTFLHLSALWLKNQVQASSLD----------------INS 916

  Fly   899 EYKRLERIDETLTALLETPLKTTDKVQQFENHCVLLEALHGSVTAGVPFENACLSRNEIL----- 958
            ....|..:|:.|..|||:            ....|:....|||   :|.::......:.|
Human   917 LQVLLSAVDDLLNTLLES------------EDSYLMGVYIGSV---MPNDSEWEKMRQSLPMQWL 966

  Fly   959 --PLLQ-RSTLN---FSTIYKLVYQFPPPQDTNDPEDELTEDYCDPNADVLKKW----------- 1006
              |||: |.:||   |.|.:|       .||..    .|....|  .:.:|.|.
Human   967 HRPLLEGRLSLNYECFKTDFK-------EQDIK----TLPSHLC--TSALLSKMVLIALRKETVL 1018

  Fly  1007 ----NEPLIAELLQCIR-----------VAGTAECWLEMSVLQSSTEELVLILSEKVQSFMGNSS 1056
                .|.:|||||..::           :.|..|...:|::...:...|            ||:|
Human  1019 ENNELEKIIAELLYSLQWCEELDNPPIFLIGFCEILQKMNITYDNLRVL------------GNTS 1071

  Fly  1057 DLVAIVKERLQQAAVQQSSVIDCRLLSYLRFCPQYAAFEESASILLHEDLSENLV---------- 1111
            .|:.::..|.::.....|.:|                    |.::|...:|.:.|
Human  1072 GLLQLLFNRSREHGTLWSLII--------------------AKLILSRSISSDEVKPHYKRKESF 1116

  Fly  1112 ---TQGALKTYVIALQFLLPKLSQK-----AITLSSAIMGTEPPEIWVK------------AAVF 1156
               |:|.|.|    :|.|.|.||::     :.....|::|      |.|            .|:|
Human  1117 FPLTEGNLHT----IQSLCPFLSKEEKKEFSAQCIPALLG------WTKKDLCSTNGGFGHLAIF 1171

  Fly  1157 HALLLNNFEGDVNEQT----DRNIIVSAVQFMTSIGERQASQKDLLHYNVEIQRQPYESVINTVE 1217
            ::.|          ||    |..::...::.:.|   .:...:|:..::..:.....|.:...:|
Human  1172 NSCL----------QTKSIDDGELLHGILKIIIS---WKKEHEDIFLFSCNLSEASPEVLGVNIE 1223

  Fly  1218 FIKLLTEVLKRFPYELSIKNWDAIRIGLSSWVLSVSKSIAQYQDPKTSLFIVAVYELFAALIDFI 1282
            .|:.|:..||.....|:...||.|...:.:|:.:.|::.|.|..|...||.....:|...|..|.
Human  1224 IIRFLSLFLKYCSSPLAESEWDFIMCSMLAWLETTSENQALYSIPLVQLFACVSCDLACDLSAFF 1288

  Fly  1283 RSEKQKSSTELLKNMIDEWDSLFAKEVNLVLFKSYYLLTHE---VSVDPGFQACYEALLEQITPV 1344
            .|....:...|..|:|.||...|::.::.:|......:|.|   || :..||   .|:|:   |:
Human  1289 DSTTLDTIGNLPVNLISEWKEFFSQGIHSLLLPILVTVTGENKDVS-ETSFQ---NAMLK---PM 1346

  Fly  1345 IERLDY------------SFVYSFCKSNSNITLDHLCNFLFKQLYSVQHSVRLSAVHSLRQL--- 1394
            .|.|.|            :.:.:..|:|....|..|.|.|...|......|:::..|.|.:|
Human  1347 CETLTYISKEQLLSHKLPARLVADQKTNLPEYLQTLLNTLAPLLLFRARPVQIAVYHMLYKLMPE 1411

  Fly  1395 TPHFVADDIELNEKQSESLDASTTICKWHFLNRFEDYLTRYDALITKYLEEFTFKLSELDDLEPI 1459
            .|.:..|:::....:.|....|........|:..||.|......|         .:.::..::|:
Human  1412 LPQYDQDNLKSYGDEEEEPALSPPAALMSLLSIQEDLLENVLGCI---------PVGQIVTIKPL 1467

  Fly  1460 --DRHNALSYLFLWDCIINACAKSPVALRAVYTNWLNDNKYEENFLHFLFRAMP---------VD 1513
              |....|.||..|..|:.....:...|||:|:.:|...|.....|:.|||.||         |:
Human  1468 SEDFCYVLGYLLTWKLILTFFKAASSQLRALYSMYLRKTKSLNKLLYHLFRLMPENPTYAETAVE 1532

  Fly  1514 ILKNHGAKVHSNGVYKELTWSQQKDRHLP--LERYACHLYTEVLRKLPAVVRRWWNATQSRQKNF 1576
            : .|...|....   :||..|.::...||  :...||.:|...|:.|||:||.|||:::.|..|.
Human  1533 V-PNKDPKTFFT---EELQLSIRETTMLPYHIPHLACSVYHMTLKDLPAMVRLWWNSSEKRVFNI 1593

  Fly  1577 IDNLTTNYVSSLICSEELKAIANRKEKHENMQVTVHSSTREVLAVYAIDEARMELVITLAPNYPL 1641
            :|..|:.||||::..:|:.::....:....|.|...::||||:|.|.|::..:||:|.|..||||
Human  1594 VDRFTSKYVSSVLSFQEISSVQTSTQLFNGMTVKARATTREVMATYTIEDIVIELIIQLPSNYPL 1658

  Fly  1642 GAVKVECGKQIGGRASS-RNVGMQLTIFLTHQNGTIYDGLTMWKNNLDKKFEGVEECYVCYTVIH 1705
            |::.||.||::|..... ||..:||:.:||||||:|.:||.:||||:||:|||||:|.:|::|||
Human  1659 GSIIVESGKRVGVAVQQWRNWMLQLSTYLTHQNGSIMEGLALWKNNVDKRFEGVEDCMICFSVIH 1723

  Fly  1706 QETCQLPKLTCKTCKKKFHGPCLYKWFTTSSKSTCPICRNVF 1747
            .....|||..|:|||||||..|||||||:|:|||||:||..|
Human  1724 GFNYSLPKKACRTCKKKFHSACLYKWFTSSNKSTCPLCRETF 1765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ltn1	NP_730427.1	RING	<1724..1744	CDD:302633	14/19 (74%)
LTN1	NP_056380.3	COG5219	59..>262	CDD:227544	73/209 (35%)
		HEAT 1. /evidence=ECO:0000255	59..96		14/36 (39%)
		HEAT 2. /evidence=ECO:0000255	100..138		13/37 (35%)
		HEAT 3. /evidence=ECO:0000255	273..314		11/42 (26%)
		HEAT 4. /evidence=ECO:0000255	335..372		16/36 (44%)
		HEAT 5. /evidence=ECO:0000255	380..418		11/38 (29%)
		HEAT 6. /evidence=ECO:0000255	433..473		7/39 (18%)
		HEAT 7. /evidence=ECO:0000255	513..551		11/38 (29%)
		HEAT 8. /evidence=ECO:0000255	611..658		8/46 (17%)
		HEAT 9. /evidence=ECO:0000255	676..714		4/37 (11%)
		HEAT 10. /evidence=ECO:0000255	768..810		10/41 (24%)
		HEAT 11. /evidence=ECO:0000255	911..949		13/68 (19%)
		HEAT 12. /evidence=ECO:0000255	1068..1105		10/56 (18%)
		HEAT 13. /evidence=ECO:0000255	1184..1227		5/45 (11%)
		HEAT 14. /evidence=ECO:0000255	1314..1352		12/44 (27%)
		HEAT 15. /evidence=ECO:0000255	1377..1414		9/36 (25%)
		HEAT 16. /evidence=ECO:0000255	1475..1512		11/36 (31%)
		COG5219	<1477..1765	CDD:227544	123/291 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158110
Domainoid	1	1.000	463	1.000	Domainoid score	I479
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	542	1.000	Inparanoid score	I1185
Isobase	1	0.950	-	0	Normalized mean entropy	S6253
OMA	1	1.010	-	-		QHG55728
OrthoDB	1	1.010	-	-		D19753at2759
OrthoFinder	1	1.000	-	-		FOG0004053
OrthoInspector	1	1.000	-	-		oto90117
orthoMCL	1	0.900	-	-		OOG6_106539
Panther	1	1.100	-	-	LDO	PTHR12389
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R672
SonicParanoid	1	1.000	-	-		X2799
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.890