Protein Alignment Ltn1 and Y54E10A.11

DIOPT Version :9

• Sequence 1: NP_730427.1
• Gene: Ltn1 / 40127
• FlyBaseID: FBgn0262517
• Length: 1747
• Species: Drosophila melanogaster
• Sequence 2: NP_491118.2
• Gene: Y54E10A.11 / 171893
• WormBaseID: WBGene00021831
• Length: 1446
• Species: Caenorhabditis elegans
• Alignment Length: 1961
• Identity: 418/1961 - (21%)
• Similarity: 668/1961 - (34%)
• Gaps: 744/1961 - (37%)

  Fly    10 RTKNNAKPSSSSRTAELLGSSTPIFVGFSAQTDGGGLVPFAPGF--ASAEQMPDSFDAAISPQTQ 72
            |.|.|||.:||:...|.|......||         ||.|....|  ||:.::....:  |..:|:
 Worm     6 RRKGNAKNASSAAAHEYLAQGGATFV---------GLTPEMNIFEVASSNRLHQVVE--IDDETR 59

  Fly    73 IILRKLSKKDPMTKKKALQELHELI--EQSDVEVLKNILPLWPKY------YLNLASDPEHTVRE 129
            |:::||:|||..|::|.|:||.|||  |.|.:|         ..|      ...|.:|...|||.
 Worm    60 IVMKKLTKKDCQTREKGLKELMELINTENSSIE---------SSYEHFCGLVAQLTTDGSPTVRM 115

  Fly   130 QTQTVLQLLMAKCKKAMAPYLKLLVPVWLGSRFDTYAPAASIASQSFRDTFAGNANRSREVCMHC 194
            .|..|:...:.|.||:.:..||.::|..|.::.|.....|:.||...||.|  :|::.|:|
 Worm   116 LTMKVISQFLTKLKKSASKGLKKIIPFVLFAKSDVTNGVAAAASAVIRDGF--DADKKRQV---- 174

  Fly   195 QVEILEYATRNLTFHTAATLSIGK---SL-----TPEDAEQKYQRVIISSLKLLSFFMGQTAQTE 251
                :|....| ||..||.::.||   ||     ..||.|.:..|:...||...
 Worm   175 ----VELFVPN-TFDLAAKIAEGKHELSLPAEYDASEDLETRKMRLETQSLNTF----------- 223

  Fly   252 ELSQVKEGFGTLVAHQKFW-----------SFAKHKVPAIKAAWFECIYHILQSVALLDVITPQK 305
             ||.:|| :|.   ..|.|           .|.|......|.|                    .|
 Worm   224 -LSYIKE-YGN---ESKLWEEPARKLFSNSEFIKKTFAGKKEA--------------------LK 263

  Fly   306 TQLTNLCFQFIDD-----ADPVVAPHI----------------W-GCVLLLQSNYVDWFVPLNIR 348
            .||.|:.::|.|:     ::||::.:|                | |.::||...  .:....:::
 Worm   264 VQLLNISYKFSDNIEVILSNPVISTYIQASLDAQTFSTECATAWEGILILLPDE--RFHAKCSLQ 326

  Fly   349 KTLLPKLSSLLQNGFNRNAQAICPNLLPFLSKVTQ------------------------ASLQDL 389
            |.:.|:|.:|::...| :.:.:...|||.:|.:.|                        ||:..:
 Worm   327 KGIYPRLLNLIRKKGN-HWRVLKHYLLPAVSVLLQKLENPALITSIITSFTDNLPWQAEASMNAI 390

  Fly   390 DIY-----DFYQRFF--DDMKLAVTKKFDPPLSKSDCIVIHNAYF------ECLRFLMQQINNNK 441
            ..:     ||.:...  |.:.|.:.|...|.:.:.....:|   |      ||:..|:..|...|
 Worm   391 HCWFCTFSDFVKWILGNDRINLEILKDLSPLIVEMSNQSMH---FNTAEATECISGLIHWIIEKK 452

  Fly   442 QREQKEEEFSFSLLDNNVLE---PIAWLLKSDS-----THVKIFFQHSSAL----VAF------- 487
            ..|...|  .|.||..::.|   |....|.:||     .|:::...|.:.|    |.|
 Worm   453 VLENPAE--FFDLLKTSIYEVAPPEKSRLFADSLTLPAKHLELAHLHGNLLSNPDVDFHIIRNLA 515

  Fly   488 ----------WDRQINN--RLDNGDLYAKLLNKFWIRIFELVTQDLSAEEVNEQLLGHVLLLVQD 540
                      ..|.|||  .::|.|.:..|.....:::.|: ...||.:..|.. :|..|||.::
 Worm   516 RASNSEYFEETCRNINNFEFIENSDRFDMLQAVEIVKLIEM-KPSLSLQIKNNH-VGRQLLLSEN 578

  Fly   541 LHMANPSLES-PSVKFVEGPNEKIEKSEPTTPVKKAQEAAAFIQK-------------------- 584
            ..:...||:: |:..|.|..|...||...    |...:|..|::|
 Worm   579 SEIWEKSLKNVPAGVFQEMVNFWHEKRNG----KAIAQAVNFLKKMGIQLDTNAAAENVDFLISL 639

  Fly   585 -----------ELKQLVIKLVRICLDKANKGSGSGTSSSRYIEQIRTLTKMFNDAAFYKSLTDDG 638
                       |.|.||:||:....|..::..         :|...:|....|           |
 Worm   640 LQSLDSKEDPEERKNLVLKLLSALFDAEDEPK---------LEHFESLKSHLN-----------G 684

  Fly   639 DLASALNKFVSLLGQLSCQACESVVEIVFEILPLLETGKRFEYIENTLMKLPQHGVQNLLLHRLL 703
            |......|   |...:..:..|.|:||          ..||:                    :|:
 Worm   685 DFEQFFEK---LFANMEEEDAERVLEI----------AARFD--------------------KLV 716

  Fly   704 SYPLCAEAAVRQMLSGPETCEMIARIAEEVVVDNDREKLNLLHKCFFQTDTGDILINAKTVDKIL 768
            .:   .:|..|..::|    :||....|   .|...|||:.|..        |:|..::....|.
 Worm   717 GF---CDADSRGEIAG----KMILGRRE---FDEMSEKLHFLEL--------DVLTVSQHTTIIT 763

  Fly   769 LSMCGPLEQPVVDDAVEVCGSFIAQIMPVICSNNNSSLHVRQHIFLKLF-------------KFS 820
            .::..|:|.....:|.::........:..:.||.|||:|       :||             ::.
 Worm   764 DALSRPIEHLEEKEATKMVKELGRLALFSVASNYNSSIH-------QLFAWQMIRVISALGNRYC 821

  Fly   821 LEHRPEDYLSEDTLWEITTCWQDGLSSKDIEIDDDMLK------------CCAGIVEELANSAEL 873
            |:     :|.|:            |....||::..::|            |||         ...
 Worm   822 LK-----FLDEE------------LQQLRIELEKRVIKSEEIQKLINDGCCCA---------PNF 860

  Fly   874 KADTLDGMAEAMAKFVICSTENIEDEYKRLERID---ETLTALLETPLKTTDKVQQFENHCVLLE 935
            ..||. |:.|...||         :||.  |.:|   ||:....:|||:..:||
 Worm   861 ITDTY-GIPEKRQKF---------EEYS--EDMDTKIETIYLKTDTPLEYVEKV----------- 902

  Fly   936 ALHGSVTAGVPFENACLSRNEILPLLQRSTLNFSTIYKLVYQFPPPQDTNDPEDELTEDYCDPNA 1000
                       || |..|.|. .||               :||
 Worm   903 -----------FE-ASQSENS-FPL---------------FQF---------------------- 917

  Fly  1001 DVLKKW----NEPLIAELLQCIRVAGTAE---------CWLEMSVLQSSTEELVLILSEKVQSFM 1052
            |..||:    |...:...:||......||         |.: ::||.:||:    ||.:...||.
 Worm   918 DQSKKYEWLANLTFVKRFIQCGGEIFRAENLEFRDFTLCGI-ITVLDTSTD----ILIDSPHSFS 977

  Fly  1053 GNS---------SDLVAIVKERLQQAAVQQSSVIDCRLLSYLRFCPQYAAFEESASILLHEDLSE 1108
            .|.         .:|..::.:..::.|..:.||                           |:.:|
 Worm   978 ENPLLEALTTLYLELFVVLTDATKRGAYSEQSV---------------------------EEWNE 1015

  Fly  1109 NLVTQGALKTYVIALQFLLPKLSQKAITLSSAIMGTEPPEIWVKAAVFHALLLNNFEGDVNEQTD 1173
                            |..|.:....|.|...|...:.|..:|:|.:....:::.|....:...|
 Worm  1016 ----------------FYTPTIHTYCIRLFRTIRRDQQPTPFVRALLRALFVISEFPTSFSNDDD 1064

  Fly  1174 RNIIVSAVQFMTSIGERQASQKDLLHYNVEIQRQPYESVINTVEFIKLLTEVLKRFPYELSIKNW 1238
                                                   :...|||.           |||:..:
 Worm  1065 ---------------------------------------VANQEFIP-----------ELSVFKY 1079

  Fly  1239 DAIRIGLSSWVLSVSKSIAQYQDPKTSLFIVAVYELFAALIDFIRSEKQKSSTELLKNMIDEWDS 1303
            .|.:          ...|||            .:.|||            |:.|
 Worm  1080 PAFQ----------ESCIAQ------------AFSLFA------------SNNE----------- 1099

  Fly  1304 LFAKEVNLVLFKSYYLLTHEVSVDPGFQACYEALLEQITPVIERLDYSFVYSFCKSNSNITLDHL 1368
                .:.|:.:....||                     .|::.:|:.:   :..|||.:..|...
 Worm  1100 ----HIQLIAYSVARLL---------------------MPIMFKLENA---AALKSNEDSELPVS 1136

  Fly  1369 CN-------FLFKQLYSVQHSVRLSAVHSLRQLTPHF--VADDIEL----NEKQSESLDASTTIC 1420
            .|       .:..:.|...|       |:     ||.  :..|:.|    |.|.|
 Worm  1137 TNRRKLSLPVMISKSYPKDH-------HN-----PHVGPLLLDLTLLPLENTKDS---------- 1179

  Fly  1421 KWHFLNRFEDYLTRYDALITKYLEEFTFKLSELDDLEPIDRHNALSYLFLWDCIINACAKSPVAL 1485
                                .:.:|  .:::..|.::|..: |||:.|.|
 Worm  1180 --------------------GFSQE--HRVAYCDVIDPFFK-NALNALML--------------- 1206

  Fly  1486 RAVYTNWLNDNKYEENFLHFLFRAMPVDILKNHGAKVHSNGVYKELTWSQQKDRHL-------PL 1543
                     |..:|       ||.:|:      |.::..         ||::..:|       |:
 Worm  1207 ---------DQPFE-------FRQVPI------GCRIPK---------SQERAYYLESDLSASPI 1240

  Fly  1544 --ERYACHLYTEVLRKLPAVVRRWWNATQSRQKNFIDNLTTNYVSSLICSEELKAIANRKEKHEN 1606
              :::|..|..:.:..|||.:|.::....:..........|.|.|.|:..:||..:...|.:.|
 Worm  1241 FFDKFASRLLFKSMTLLPAAIRLFYKGMPNCFMPMFQETVTKYASRLLIEQELGKVREAKFEGE- 1304

  Fly  1607 MQVTVHSSTREVLAVYAIDEARMELVITLAPNYPLGAVKVECGKQIGGRASSRNVGMQLTIFLTH 1671
            |:|.....|.|::|.|.::|.:|:|.|.|.|:|||....:...|.|.....::...:||..:|.|
 Worm  1305 MKVRTVPVTGEIIAEYVVEETKMKLTIGLPPDYPLSVPSLTLDKAIVKTDRAKKWLLQLNAYLFH 1369

  Fly  1672 QNGTIYDGLTMWKNNLDKKFEGVEECYVCYTVIHQETCQLPKLTCKTCKKKFHGPCLYKWFTTSS 1736
            |||.|.:|:.|||.|:||..||||:|.:|...:||:|.||||:.||.||.|||..||||||.:|:
 Worm  1370 QNGAILEGIEMWKRNVDKGVEGVEDCTICMMTVHQQTHQLPKIKCKQCKNKFHSNCLYKWFESSN 1434

  Fly  1737 KSTCPICRNVF 1747
            :||||:|||.|
 Worm  1435 QSTCPLCRNNF 1445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ltn1	NP_730427.1	RING	<1724..1744	CDD:302633	12/19 (63%)
Y54E10A.11	NP_491118.2	zf-RING_2	1393..1442	CDD:290367	28/48 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165908
Domainoid	1	1.000	162	1.000	Domainoid score	I2436
eggNOG	1	0.900	-	-		E1_COG5219
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2113
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19753at2759
OrthoFinder	1	1.000	-	-		FOG0004053
OrthoInspector	1	1.000	-	-		oto18426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12389
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R672
SonicParanoid	1	1.000	-	-		X2799
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.980