DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL31 and CG1812

DIOPT Version :9

Sequence 1:	NP_001003760.2	Gene:	KLHL31 / 401265	HGNCID:	21353	Length:	634	Species:	Homo sapiens
Sequence 2:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster

Alignment Length:	603	Identity:	152/603 - (25%)
Similarity:	264/603 - (43%)	Gaps:	68/603 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    59 LLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNIL--------KKDPSIQRVDLND 115
            ||.||:|:|.|..|.|:.:..:...|..|:.|:|:.|:||..:.        :||    .::|..
  Fly    34 LLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKD----EINLYG 94

Human   116 ISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAE 180
            |....:.::|.|.||..|.|:...|..|::||.::|:..::..|:.||..::.:|||:.:..:|:
  Fly    95 IKARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMAD 159

Human   181 TYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDD------DLQLPSEIVAFQI--- 236
            .|.:.:....|.:::..:|.|||.:..|.::..:|:..:|..:      :..|...:.:|.|
  Fly   160 IYGIMDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQ 224

Human   237 -----------AMKWLEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVD 290
                       .:||.....|.|    |.|.|:.......:.|........|:.|:...|.|
  Fly   225 LNESALGDLLRLIKWQHISYKSV----DELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLL--- 282

Human   291 AMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPEN-GWSKLTEMPAK 354
               ..::.....:|....|.:||....|:.:|   |.....|:..|:...|:. .|.:||.:|
  Fly   283 ---NGVVSLKDQSLPQGPTNMRGMELCLLKIG---GFEWNGLTNVIMCFSPKKMNWYELTAIP-- 339

Human   355 SFNQC---VAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSL-S 415
            ..:||   .||::..|::.||  ..|...:.......|| |.|..|||:.:|.:.|.|..||| :
  Fly   340 HIDQCNFGTAVLNNKLFIVGG--AYDVFLKEYIHPFGFC-YCPLRNTWMTIAPIQQDRCRFSLNA 401

Human   416 VFNGLVYAAGG------RNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGG- 473
            |....:||.||      ..|...::::|.|..:.|.|.....|:..|..||..|...::.::||
  Fly   402 VGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGV 466

Human   474 YIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECY 538
            ::||..: |:..:|..::.||||.::.||...|..|.:.:|:|..||........||.|..:..|
  Fly   467 HLANILA-SMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWHESLTEWRVLVEHIYAY 530

Human   539 SPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNE---WTEDD-- 598
            ...|..||....:.......||:|:....:.|||.:..|...:...:..:.:|:.   |.|.|
  Fly   531 DIETNTWSVETKIPAPKFYTGVTAMGRTIFFVGGLDSTESIDRASAETMAYDLDTKEWWHEKDSW 595

Human   599 ELPEATVGVSCCTLSMPN 616
            :.|......:|..:.:||
  Fly   596 DSPNDVWESTCVAIYVPN 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL31	NP_001003760.2	BTB	63..164	CDD:279045	30/108 (28%)
		PHA03098	73..601	CDD:222983	140/572 (24%)
		BACK	172..273	CDD:285009	22/120 (18%)
		Kelch 1	317..365		14/51 (27%)
		KELCH repeat	356..405	CDD:276965	16/51 (31%)
		Kelch 2	366..419		18/53 (34%)
		Kelch	367..419	CDD:128874	18/52 (35%)
		KELCH repeat	409..453	CDD:276965	14/50 (28%)
		Kelch	420..466	CDD:128874	14/51 (27%)
		Kelch 3	420..466		14/51 (27%)
		Kelch_1	455..500	CDD:279660	14/45 (31%)
		KELCH repeat	456..501	CDD:276965	14/45 (31%)
		Kelch 4	468..513		14/45 (31%)
		Kelch_1	502..552	CDD:279660	14/49 (29%)
		KELCH repeat	503..551	CDD:276965	13/47 (28%)
		Kelch 5	515..565		13/49 (27%)
		KELCH repeat	555..602	CDD:276965	11/51 (22%)
		Kelch 6	567..614		10/51 (20%)
CG1812	NP_608397.1	BTB	38..142	CDD:279045	29/107 (27%)
		PHA03098	46..588	CDD:222983	138/564 (24%)
		BACK	151..249	CDD:285009	18/101 (18%)
		KELCH repeat	344..390	CDD:276965	15/48 (31%)
		KELCH repeat	394..444	CDD:276965	14/49 (29%)
		Kelch	406..458	CDD:128874	14/51 (27%)
		Kelch_1	448..492	CDD:279660	14/44 (32%)
		KELCH repeat	448..492	CDD:276965	14/44 (32%)
		Kelch_1	494..539	CDD:279660	13/44 (30%)
		KELCH repeat	495..539	CDD:276965	12/43 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45416
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45632
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.030