Protein Alignment Dred and Dctn1

DIOPT Version :10

• Sequence 1: NP_649124.1
• Gene: Dred / 40124
• FlyBaseID: FBgn0036882
• Length: 1339
• Species: Drosophila melanogaster
• Sequence 2: NP_031861.2
• Gene: Dctn1 / 13191
• MGIID: 107745
• Length: 1281
• Species: Mus musculus
• Alignment Length: 1464
• Identity: 389/1464 - (26%)
• Similarity: 626/1464 - (42%)
• Gaps: 381/1464 - (26%)

  Fly     3 SPRELKLGQRVEVTGKNLQGKVAYVGRTNFAAGLWYGVVLDEPLGKNNGSVHGSIYFKCPTNCGL 67
            |.|.|::|.||||.||..:|.|||||.|.||.|.|.||:|||..|||:|:|.|..||.|....|:
Mouse    23 SARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGI 87

  Fly    68 FVRAQQLVRIAELPKGGDNRKADEMQRDGARAKLSRRSGSGKSVEEQDNQREQQASTSGKVKATS 132
            |||..|:                ::..|||
Mouse    88 FVRQSQI----------------QVFEDGA----------------------------------- 101

  Fly   133 STPSPQHKNRNTHSSMETSLAKTSGKFLATHQQPLQLPKNPVTCESSVRNSQSKETGEVTLSPKK 197
            .|.||:     |..|..:.:.|..|                  .:::.:.|:.:     .|.|||
Mouse   102 DTTSPE-----TPDSSASKVLKREG------------------ADAAAKTSKLR-----GLKPKK 138

  Fly   198 SSDIEQSKKHSQQETNETNQPASKEVEPKNENELQSTEAANSMLDTPVNPLQTSTIGQLPPQKAS 262
            :....::.....:.|    :|||..|                     ..|  :|::|  |...||
Mouse   139 APTARKTTTRRPKPT----RPASTGV---------------------AGP--SSSLG--PSGSAS 174

  Fly   263 AQLTPPPLTCNQRRSTSYTQLRPTRISQPKPTTAQAQSSTAQLTLAMPVPLALAPKRSKTSMSPT 327
            |                      ..:|..:|:|      .||..||.|:
Mouse   175 A----------------------GELSSSEPST------PAQTPLAAPI---------------- 195

  Fly   328 SSIKRVAPAAFVEPRFLEILRPQFTPGPALRTPSSVAPPLDNP---------ELRQLREELQLLR 383
                                    .|.|||.:|.: ||||.:|         ::|.|.|:|:.||
Mouse   196 ------------------------IPTPALTSPGA-APPLPSPSKEEEGLRAQVRDLEEKLETLR 235

  Fly   384 GQKSEDKLKLLELERMRIHNEQLMEFKSQIMAQQVLLQRELQRSRHELREAQDVSSKLKRELDEI 448
            .::||||.||.|||:.:|..||:.|:||::..||..|||.|:.:|.|.:||.:...:...|:.:.
Mouse   236 LKRSEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT 300

  Fly   449 AESIELLTLDKEMAEERMETLQMELEMAQERNDELSLDVEILKAEQEEQQGQRIEKSEKQIGS-G 512
            |::||:.||||||||||.|:||.|:|..:||.|||:.|:||||||.||:            || |
Mouse   301 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEK------------GSDG 353

  Fly   513 VTNQSAGEFLRLEQYNQRLRETVVRLRDTLAEEKQIGQRTHKELETKHSEINELKSIKELLSRRV 577
            ..  |:.:..:||:.|.||::.:||:||..:.|||...:..|.:|.|:.|:..::..:|.|...:
Mouse   354 AA--SSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEEL 416

  Fly   578 DNMEMQLMDLKEQVDASLGAEAMVTQLASLKLELEDRVKLLEDEVNELEALEQIQEQLIESNQEL 642
            ...|..:.:|||||||:||||.||..|....|.||::|:.|.:.|.:|||:.::.::|.|:.:|.
Mouse   417 SQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARET 481

  Fly   643 ETDLREEIDKLSGHVKILEQQKNAAMESLYDRDVTIMKFRDLVRQLQEQLQLRADGTLSIEDFSS 707
            |.:|||::|.....|:..:::..||.|::.|...||.|:|.|...||              |.:.
Mouse   482 ELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQ--------------DVNR 532

  Fly   708 ANESQQEDGSNQSQT------DYQHIFSVSKAYGRALEQQIKTVELRLQRQHLEHVLAFVPEQFL 766
            ...:|||....:.|.      |::..|:.:||:.:|:|.:::.:|:....:|:..:.||:|:.||
Mouse   533 ELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFL 597

  Fly   767 LRGGEHDVVLVMLLLERMNEKLTIVCQAINEKFPTACEFGRDAIFEGYSVQRYIFRSQCLYLLKS 831
            ..||:||.|||:||:.|:..|..::.:...|||..:..........|.:.::..|.:..:|.|..
Mouse   598 RPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSLSL 662

  Fly   832 LQLVLQQFRHGLTHCDYELCTHAAIYRSDLDAQEQQLDEFVRLLKTGQLDEHTNCEPIQRVLHY- 895
            ||..|.::.|.|:.|..::.........::.|.|:.||..:.||...||||..|.||:.:.:.|
Mouse   663 LQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYY 727

  Fly   896 --VSGLHQNLMPPQTLVELLDEQQLYEALIEVYEAGLDAVNANAGLMHTIIQLGHEQTASFSCMQ 958
              :..:|....|..:.::|.|.       |:..::.||.:....|.:...:|.|.|.| ..:.:.
Mouse   728 QHLYSIHLAEQPEDSTMQLADH-------IKFTQSALDCMGVEVGRLRAFLQGGQEAT-DIALLL 784

  Fly   959 MLMEQSCAH-KQKLKKLQRKLSGS-----KTASWTGMQCARYQRIMEANEALGTLIRLLGCTARE 1017
            ..:|.||:. :|..||::|::.|:     ..|...|.|.:  ..:::..:.|..::.:|...|..
Mouse   785 RDLETSCSDTRQFCKKIRRRMPGTDAPGIPAALAFGSQVS--DTLLDCRKHLTWVVAVLQEVAAA 847

  Fly  1018 ASK-----DSNGGI---AHEKLWRMLVLNYNKFAPSQE-----AEEPREVDAYSQRCMQLLEEQF 1069
            |::     ..|.|:   |.|:|         .|..|::     :..|.|  ...|.| .:|....
Mouse   848 AAQLIAPLAENEGLPVAALEEL---------AFKASEQIYGSPSSSPYE--CLRQSC-TILISTM 900

  Fly  1070 DELFALLDSTDVNTEYVRHPT-CNTLQERAAQVKRHYEDVKNLELTVAEREKEIKSLKYTAKMKQ 1133
            ::|...:...:.:.|  |.|: ...::.|||.::....|.:.|.|.:.:||..||.||.:.|:|.
Mouse   901 NKLATAMQEGEYDAE--RPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKG 963

  Fly  1134 QDYSELQVRKEMAEKQLSKQCHVLAGFAEAVEQLE---------QSIL-AKEAALGQALNMLADK 1188
            ::.||..||..:.||:|.      :...:|.|::|         |::| .||....:.::.|...
Mouse   964 EELSEANVRLSLLEKKLD------SAAKDADERIEKVQTRLDETQTLLRKKEKDFEETMDALQAD 1022

  Fly  1189 LTSLEQSQEHWKEQQQADS---------------ACLTS-------------------------- 1212
            :..||..:...|::..:.|               |.|.|
Mouse  1023 IDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEPQRGGAPGQAPGALPGPGLV 1087

  Fly  1213 -------TTISSNREMNMLH-QALRQERSLRVELQGSEMRKTFAALEPLHVPQ------------ 1257
                   ..||:.|    || ..|:.|.|:   |:|::|:.:.|||.||||.:
Mouse  1088 KDSPLLLQQISAMR----LHISQLQHENSI---LRGAQMKASLAALPPLHVAKLSLPPHEGPGGN 1145

  Fly  1258 --AGS--QELTDLEKDLRSLKNQWLLAH------------------LEMGAAGRQRRSEIELQGS 1300
              ||:  ::.:.|.:.|..|...   .|                  :|..|..:.....||....
Mouse  1146 LVAGALYRKTSQLLEKLNQLSTH---THVVDITRSSPAAKSPSAQLMEQVAQLKSLSDTIEKLKD 1207

  Fly  1301 RVLRHIFHTYCTQHPHRAKNTDFGLFITEDLRRA 1334
            .||:..    .||.|.....|||..|.:....||
Mouse  1208 EVLKET----VTQRPGATVPTDFATFPSSAFLRA 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dred	NP_649124.1	CAP_GLY	9..74	CDD:460154	36/64 (56%)
		Metaviral_G	171..306	CDD:462833	22/134 (16%)
		Smc	<373..>704	CDD:440809	130/331 (39%)
		Dynactin	688..967	CDD:463591	73/287 (25%)
		Smc	<1092..>1305	CDD:440809	66/305 (22%)
Dctn1	NP_031861.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		1/2 (50%)
		CAP_GLY	29..94	CDD:460154	36/64 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..221		44/281 (16%)
		Herpes_BLLF1	<101..>214	CDD:282904	42/273 (15%)
		SMC_prok_B	220..>540	CDD:274008	133/347 (38%)
		Dynactin	527..805	CDD:463591	77/299 (26%)
		Interaction with HPS6. /evidence=ECO:0000269|PubMed:25189619	911..1281		78/349 (22%)
		Smc	<926..>1046	CDD:440809	33/125 (26%)