Protein Alignment Dred and dctn1b

DIOPT Version :10

• Sequence 1: NP_649124.1
• Gene: Dred / 40124
• FlyBaseID: FBgn0036882
• Length: 1339
• Species: Drosophila melanogaster
• Sequence 2: XP_021336434.1
• Gene: dctn1b / 100003026
• ZFINID: ZDB-GENE-050419-28
• Length: 1264
• Species: Danio rerio
• Alignment Length: 1454
• Identity: 386/1454 - (26%)
• Similarity: 597/1454 - (41%)
• Gaps: 400/1454 - (27%)

  Fly     5 RELKLGQRVEVTGKNLQGKVAYVGRTNFAAGLWYGVVLDEPLGKNNGSVHGSIYFKCPTNCGLFV 69
            |.:|:|..|||.||..:|.|||:|.|.||:|.|.||:||||.|||:|:|.|..||.|..|.|:||
Zfish    27 RPVKVGSLVEVIGKGHRGTVAYIGNTLFASGKWVGVILDEPKGKNDGTVQGKRYFLCQENHGIFV 91

  Fly    70 RAQQLVRIAELPKGGDNRKADEMQRDGARAKLSRRSGSGKSVEEQDNQREQQASTSGKVKATSST 134
            |..|:                ::..|||                                   .|
Zfish    92 RQSQI----------------QLVEDGA-----------------------------------DT 105

  Fly   135 PSPQHKNRNTHSSMETSLAKTSGKFLATHQQPLQLPKNPVTCESSVRNSQSKETGEVTLSPKKSS 199
            .||           ||..|.|| |.|                                    |..
Zfish   106 TSP-----------ETPEALTS-KML------------------------------------KRE 122

  Fly   200 DIEQSKKHSQQETNETNQPASKEVEPKNENELQSTEAANSMLDTPVNPLQT-STIG-QLPPQKAS 262
            .||..|.:..:.|.....|.:::.                   |...|.|| :.:| ::....||
Zfish   123 IIEGLKSNKVRGTKPKKAPTTRKT-------------------TTRRPKQTRAGVGVKVGSGSAS 168

  Fly   263 AQLTPPPLTCNQRRSTSYTQLRPTRISQPKPTTAQAQSSTAQLTLAMPVPLALAPKRSKTSMSPT 327
            |                      ..:|..:|:|      .||..||.||
Zfish   169 A----------------------GEMSSSEPST------PAQTPLAAPV---------------- 189

  Fly   328 SSIKRVAPAAFVEPRFLEILRPQFTPGPALRTPSSVAPPLDNPE---------LRQLREELQLLR 383
                                    .|.|....||..|||:..|.         ::.|.|:|:.|:
Zfish   190 ------------------------IPSPVGALPSPGAPPIPGPSKEEESLRALVKDLEEKLETLK 230

  Fly   384 GQKSEDKLKLLELERMRIHNEQLMEFKSQIMAQQVLLQRELQRSRHELREAQDVSSKLKRELDEI 448
            .:::|||.||.|||:.:|..|||.|:||::..||..||::|:.::.|.:||.:...:...|:.:.
Zfish   231 MKRTEDKAKLKELEKHKIQLEQLQEWKSKMQEQQNELQKQLKEAKREAKEALEAKERYMEEMADT 295

  Fly   449 AESIELLTLDKEMAEERMETLQMELEMAQERNDELSLDVEILKAEQEEQQGQRIEKSEKQIGS-G 512
            |::||:.||||||||||.|:||:|.:..:||.|||::|:||||.|.||:            || |
Zfish   296 ADAIEMATLDKEMAEERAESLQLEADALKERVDELTMDLEILKHEIEEK------------GSDG 348

  Fly   513 VTNQSAGEFLRLEQYNQRLRETVVRLRDTLAEEKQIGQRTHKELETKHSEINELKSIKELLSRRV 577
            ..  |:....:||:.|.||:|.:||:||..|.|||...:..|.:|.|:.|::.|:..||.|...:
Zfish   349 AA--SSYHVKQLEEQNARLKEALVRMRDLSASEKQEHGKQQKLMEKKNFELDALRCHKEKLQEEM 411

  Fly   578 DNMEMQLMDLKEQVDASLGAEAMVTQLASLKLELEDRVKLLEDEVNELEALEQIQEQLIESNQEL 642
            ...|..:.:||||||||||||.||..|....|:||::|:.|.:.|.:|||:.::.::|.|:.:|.
Zfish   412 KMAEKTIDELKEQVDASLGAEEMVEMLTERNLDLEEKVRELRETVADLEAINEMNDELQENARET 476

  Fly   643 ETDLREEIDKLSGHVKILEQQKNAAMESLYDRDVTIMKFRDLVRQLQE---QLQLRADGTLSIED 704
            |.:|||::|..:..|:..|::..||.|::.|...||.|:|:|...|||   :|.
Zfish   477 ELELREQLDLGAAGVREAEKRVEAAQETVADYQQTIQKYRELTANLQEVNRELM----------- 530

  Fly   705 FSSANESQQEDGSNQSQT-----DYQHIFSVSKAYGRALEQQIKTVELRLQRQHLEHVLAFVPEQ 764
                  ||||..|.|.|.     |::..|:.:|||.:|:|.:::.:|:....:.:..:::|:|:.
Zfish   531 ------SQQEANSEQQQQPAEIFDFKIKFAETKAYAKAIEMELRKMEVIQANRQVSLLISFMPDS 589

  Fly   765 FLLRGGEHDVVLVMLLLERMNEKLTIVCQAINEKFPTACEFGRDAIFEGYSVQRYIFRSQCLYLL 829
            ||...|:||.:|.:||:.|:..|..::.:...|||.......:.....|...:|..|.:..:|.|
Zfish   590 FLKHRGDHDCILALLLIPRLICKSELISKQAQEKFELTESCSQKPGMRGAVGERLSFAAGLIYSL 654

  Fly   830 KSLQLVLQQFRHGLTHCDYELCTHAAIYRSDLDAQEQQLDEFVRLLKTGQLDEHTNCEPIQRVLH 894
            ..||..|.::.|.|:.|..::........|:|...|:.||..:.||....|||..|.||:.:.:.
Zfish   655 TLLQAALHKYEHALSQCSVDVYKRVGSLYSELSVHERSLDFLIDLLYKDLLDETVNVEPLTKAIK 719

  Fly   895 Y---VSGLHQNLMPPQTLVELLDEQQLYEALIEVYEAGLDAVNANAGLMHTIIQLGHEQTASFSC 956
            |   :..:|....|....::|.|.       |...::.||.:....|.:...||.|.::.| |..
Zfish   720 YYQHLYSIHLAEQPEDCTMQLADH-------IRFTQSALDCMAVEVGRLRAFIQTGQDEEA-FCV 776

  Fly   957 MQMLMEQSCAH-KQKLKKLQRKLSGSKTASWTGMQCARYQRIMEANEALGTLIRL-LGCTAREAS 1019
            :...::.||:. :|..||::|::.|:                    :|.|....| .|....||.
Zfish   777 LLKDLDTSCSDIRQFCKKIRRRMPGT--------------------DAPGIPAALSFGPQVCEAL 821

  Fly  1020 KDSNGGIAHEKLWRMLVLN------YNKFAPSQEAEEPREVDAYSQRCMQLLEEQFDELFALLDS 1078
            .||...:|    |...||.      ....||..|.|        ....::|.:..|.....:..|
Zfish   822 ADSRRQLA----WVNAVLQEVAAAAAQLIAPLSEHE--------GLPAVKLEDMAFKAAEQIYGS 874

  Fly  1079 TDVNTEYVRHPTCN-----------TLQE-----------------RAAQVKRHYEDVKNLELTV 1115
            ..:|.:.....:|:           .:||                 |||.::....|.:.|.|.:
Zfish   875 QGINAQECLRQSCSVVIATMNKMATAMQEGEYDSDRPQTGISPVEVRAAALRAEITDAEGLGLKL 939

  Fly  1116 AEREKEIKSLKYTAKMKQQDYSELQVRKEMAEKQL---SKQCHVLAGFAEAVEQLEQSIL----- 1172
            .:||..||.||.:.|:|.::.||..||..:.||:|   ||...      |.||:: |:||
Zfish   940 EDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSASKDAD------ERVEKI-QAILDETDS 997

  Fly  1173 ---AKEAALGQALNMLADKLTSLEQSQ---------------EHWKEQQQADSACLTSTTISSNR 1219
               .||....:.::.|...:..||..:               |..:..|.:..|.:.:..|::..
Zfish   998 LLKKKEKEFEETMDALQADIDQLESEKVELKHRISSQSKMTIESLRGSQASGIASIVTCGITAEE 1062

  Fly  1220 EMN-------------MLHQALRQER----SLRVE---LQGSEMRKTFAALEPLHVPQAGSQE-- 1262
            :..             :|.|.:..:|    .|:.|   |:...||...|:|.||:||:.|.:|
Zfish  1063 QKGVCAAAGLQVIDSPLLTQQIEAQRLSIKHLKNENNRLKAERMRAQLASLPPLNVPKLGWREGC 1127

  Fly  1263 -LTDLEKDLRSLKNQWLLAHLEMGA-------AGRQRRS--------EIELQG---------SRV 1302
             ...|...|....:|.|...|:|.|       .||...|        ...||.         ..|
Zfish  1128 RPEVLSSALYRKTDQLLDTLLQMSANVKVVDITGRSPVSPSAQLLEQTARLQSLNDTLDRLKDEV 1192

  Fly  1303 LRHIFHTYCTQHPHRAKNTDFGLF 1326
            ..|:    .|..|....::||..|
Zfish  1193 AEHV----VTHRPGAQVSSDFATF 1212

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dred	NP_649124.1	CAP_GLY	9..74	CDD:460154	36/64 (56%)
		Metaviral_G	171..306	CDD:462833	19/136 (14%)
		Smc	<373..>704	CDD:440809	132/334 (40%)
		Dynactin	688..967	CDD:463591	74/289 (26%)
		Smc	<1092..>1305	CDD:440809	69/313 (22%)
dctn1b	XP_021336434.1	CAP_GLY	31..96	CDD:460154	36/64 (56%)
		PRK02224	<212..>548	CDD:179385	139/366 (38%)
		Dynactin	522..799	CDD:463591	78/301 (26%)