DRSC/TRiP Functional Genomics Resources

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Protein Alignment brv1 and PKD2L1

DIOPT Version :10

Sequence 1:NP_649116.1 Gene:brv1 / 40116 FlyBaseID:FBgn0036874 Length:728 Species:Drosophila melanogaster
Sequence 2:NP_057196.2 Gene:PKD2L1 / 9033 HGNCID:9011 Length:805 Species:Homo sapiens


Alignment Length:743 Identity:162/743 - (21%)
Similarity:274/743 - (36%) Gaps:159/743 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 IMSLDAAFW--PAHQAPETPDENANVDTFMDNLRLRLRTLRSELMITERHRNERVNLKYR----- 119
            :..|.:..|  ||:..|.:|.....|.|......|:.:..:.|        :|.....||     
Human    12 LQKLGSGAWDNPAYSGPPSPHGTLRVCTISSTGPLQPQPKKPE--------DEPQETAYRTQVSS 68

  Fly   120 ---------------LITE------ELWL--TGKLFLVY--FFMALAFF------DELLYFNTEA 153
                           .:||      ||::  |.:..|||  |.:.:...      ....|:....
Human    69 CCLHICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVM 133

  Fly   154 TELLFQCNHGDAFGLLSVGDVPDIYFFVVSSLV--LAFTDGKNTS----GGAPWIHAEGTRLLGV 212
            :||.............::..:.|.:.|....|:  |.:|...|..    |...:|:.| ..||||
Human   134 SELFLHTPSDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSLGHGSHSFIYYE-NMLLGV 197

  Fly   213 VRLRQLRTESNRLGLSLPVFTERDFSE-------------SWTLPYERVPYTDKYWPIYTPWLPS 264
            .|||||:..::      ......||.|             ...||:.  |:....|..::     
Human   198 PRLRQLKVRND------SCVVHEDFREDILSCYDVYSPDKEEQLPFG--PFNGTAWTYHS----- 249

  Fly   265 VSVARDNLLMGINHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLY 329
                 .:.|.|.:|.|.:.:| ...||.:.|..:|..|.:.:..|.:..|||..|..:|:|||:|
Human   250 -----QDELGGFSHWGRLTSY-SGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVY 308

  Fly   330 NADANTFTVCTLWVEKFPY---QYPDGHTRIESHTFVEQLR-----EFTKFGMLMVFVFVVTWLQ 386
            ||:.|.|.|..|.|| ||.   ..|....|.     |:.:|     :|...|..::|...:.:..
Human   309 NANINLFCVLRLVVE-FPATGGAIPSWQIRT-----VKLIRYVSNWDFFIVGCEVIFCVFIFYYV 367

  Fly   387 FTKAFFLKVWYDPRQLKTLWVQVDAMIVALSLV-VGM----IMSVRDNLVQKMIKSVEIAVVVDF 446
            ..:...|.: :..|.|.::|..:|.:::.||:| ||.    .:.| :.|:.|:::........:|
Human   368 VEEILELHI-HRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEV-NRLMGKLLQQPNTYADFEF 430

  Fly   447 LDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVITVIFIIA 511
            |.|   .|..|.......|..|.:  :::|.:.|:.|....:.|:|.....:|...|:..|...|
Human   431 LAF---WQTQYNNMNAVNLFFAWI--KIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFA 490

  Fly   512 IGIATVTINGNYTSNFRDFPKGIVTVTCFAFGYTNLVYPPDIFY-----GGEWLGILLYTIMGFV 571
            .......:.|....||..|.|.|.|......|        |..|     ....||...:....|.
Human   491 YAQLGYLLFGTQVENFSTFIKCIFTQFRIILG--------DFDYNAIDNANRILGPAYFVTYVFF 547

  Fly   572 VKYMLINLIVSMMRDQMASVK------------ADRDKKVRQRITFWQFLRVEYAHFINYIVKVF 624
            |.::|:|:.::::.|..:.||            :|..|:...:......||.|.   ::.:.||.
Human   548 VFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKER---VSDVQKVL 609

  Fly   625 HCQKGYQRKNRTVAQNIQRKLNSNELKRRKTKISSIYSETIYVMPIDKD-------LEQMKYRER 682
              |.|.|........|..|:|...|  ...|::::.:::      .|:|       .||.|.|:.
Human   610 --QGGEQEIQFEDFTNTLRELGHAE--HEITELTATFTK------FDRDGNRILDEKEQEKMRQD 664

  Fly   683 IERTFTLAAILHTQMELMERLMFGDEEG 710
            :|..   ...|:|::|.:.|.:....:|
Human   665 LEEE---RVALNTEIEKLGRSIVSSPQG 689

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
brv1NP_649116.1 Polycystin_dom 167..363 CDD:466668 57/217 (26%)
PKD_channel 364..591 CDD:462341 50/241 (21%)
PKD2L1NP_057196.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..59 11/54 (20%)
Polycystin_dom 147..342 CDD:466668 58/220 (26%)
PKD_channel 343..567 CDD:462341 50/238 (21%)
Fer4_24 702..735 CDD:436280
Required for homooligomerization 704..763
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 759..805
Blue background indicates that the domain is not in the aligned region.

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