DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv1 and Pkd1l2

DIOPT Version :9

Sequence 1:	NP_649116.1	Gene:	brv1 / 40116	FlyBaseID:	FBgn0036874	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_036010263.1	Gene:	Pkd1l2 / 76645	MGIID:	2664668	Length:	2466	Species:	Mus musculus

Alignment Length:	680	Identity:	143/680 - (21%)
Similarity:	241/680 - (35%)	Gaps:	199/680 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 CVACIWMF----SG--------FRHEYGKFNMI--LVAFLAVTLLQ-ILIFTPIKFTIMSLDAAF 69
            ||...|:.    ||        :...||:.:.:  |:: :||:.:: :.|..|:|  ::...|.|
Mouse  1822 CVLVGWLLVATTSGVAAFFTMLYGLHYGRVSSLKWLIS-MAVSFVESVFITQPLK--VLGFAAFF 1883

  Fly    70 ---------------WPAHQAPETPDENANVDTFMDNLRLRLRTLRSELMITERHRNER------ 113
                           :|.|.:...|                     ..|..:.||.:||
Mouse  1884 ALVLKREDDEETLPLFPGHLSSPGP---------------------GVLFRSRRHSSERAYQPPP 1927

  Fly   114 ---------VNLK----YRLITEELWLTGKLFLVYFFMALAFF----DELLYFNTEATELLFQCN 161
                     ..||    :.||.|.|     .:|.:.:|.|...    |...|......|..|...
Mouse  1928 MAAIEKMKTTRLKEQKAFALIREIL-----AYLAFLWMLLLVAYGQRDPNAYHFHRHLERSFSQG 1987

  Fly   162 HGDAFGLLSVGDVPDIYFFVVSSLVLAFTDGKNTSGGAPWIHAEG-TRLLGVVRLRQLRTESNRL 225
            .....|...        ||..::..|.    ||..|..|....:| ::|:|...:||:|...:..
Mouse  1988 FSPVLGFRG--------FFEWANTTLV----KNLYGHHPGFVTDGNSKLVGSAHIRQVRVRESSC 2040

  Fly   226 GL---------------SLPVFTERDFSESWTL-PYERVPYTDKYWPI--------YTPWLPSVS 266
            .:               ||.:....|:.|.|.. .|.......:.|..        |..|
Mouse  2041 AVAQQLQDSLDGCHGPYSLGIEDLVDYGEGWNASAYNNSNGFPQAWRYQSQSQRRGYPMW----- 2100

  Fly   267 VARDNLLMGINHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNA 331
                         |.:..| ...||.|.|......:.:|:.||...:||||.|.|:|::|::|||
Mouse  2101 -------------GKLTLY-GGGGYVVPLGTDHQSASRILQYLFDNSWLDALTRAVFVEFTVYNA 2151

  Fly   332 DANTFTVCTLWVEKFPYQYPDGHTRIESHTFVEQLREFTKFGMLMVFVFVVTWLQFTKA----FF 392
            :.|.|...||.:|      ..|.....||..::.||         ::.|...|..|..|    :|
Mouse  2152 NVNLFCTVTLTLE------TSGLGTFFSHVTLQSLR---------LYPFTDGWHPFVVAAELTYF 2201

  Fly   393 LKVWYD-------PRQLK-----TLWVQVDAMIVALS---LVVGM---IMSVRDNLVQKMIKSVE 439
            |.::|.       .|:.|     :.|..::..|:..|   |||.:   |::.||  :|:..:..:
Mouse  2202 LFLFYYMVVQGKLMRKQKWGYFCSKWNLLEVAIILASWSALVVFVKRTILADRD--LQRYREHRD 2264

  Fly   440 IAVVVDFLDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVI 504
                 :.:.|.|.|........:....|.|.|::||.:|:.:....:.|..:..||..:.....:
Mouse  2265 -----EGISFSETAAADAALGYIIAFLVLLSTVKLWHLLRLNPKMNMITSALRRAWGDISGFVAV 2324

  Fly   505 TVIFIIAIGIATVTING----NYTSNFRDFPKGIVTVTCFAFGYTNLV-YPPDIFYGGEWLGILL 564
            .:|.::|...|:..:.|    :|.:.| |..:.:|::....|.|..:: |.|       .||.||
Mouse  2325 ILIMLLAYSFASNLVFGWKLRSYKTLF-DAAETMVSLQLGIFNYEEVLDYSP-------ILGSLL 2381

  Fly   565 ----YTIMGFVVKYMLINLIVSMMRDQMAS 590
                ...|.|||..:.|::|:....::..|
Mouse  2382 IGSCIVFMTFVVLNLFISVILVAFSEEQKS 2411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	107/482 (22%)
Pkd1l2	XP_036010263.1	CLECT	28..154	CDD:214480
		Gal_Lectin	170..252	CDD:396628
		REJ	493..866	CDD:366875
		GPS	1282..1321	CDD:396408
		PLAT_polycystin	1392..1511	CDD:238850
		PKD_channel	1987..2407	CDD:400395	106/480 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020