Protein Alignment brv1 and Pkd1l2

DIOPT Version :10

• Sequence 1: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: XP_038954049.1
• Gene: Pkd1l2 / 691069
• RGDID: 1588631
• Length: 2492
• Species: Rattus norvegicus
• Alignment Length: 605
• Identity: 131/605 - (21%)
• Similarity: 217/605 - (35%)
• Gaps: 137/605 - (22%)

  Fly   102 ELMITERHRNERVNLKYRLITEELWLTGKLFLVYFFMALAFFDELLY-FNTEATELLFQCNHGDA 165
            |.|.|.|.:.::.   :.||.|.|...|.|::: ..:|....|...| ||........|
  Rat  1958 EKMKTARLKEQKA---FALIREILAYLGFLWML-LLVAYGQRDPSAYHFNRHLERSFTQ------ 2012

  Fly   166 FGLLSVGDVPDIYFFVVSSLVLAFTDGKNTSGGAPWIHAEG-TRLLGVVRLRQLRTESN------ 223
             |..:|.|......:..::||      ||..|..|....:| ::|:|...|||:|...:
  Rat  2013 -GFSAVLDFRGFLEWANTTLV------KNLYGHHPGFVTDGNSKLVGSAHLRQVRVRESSCAVAW 2070

  Fly   224 ---------RLGLSLPVFTERDFSESWTL-PYERVPYTDKYWPI--------YTPWLPSVSVARD 270
                     |...||......|:.|.|.. .:.......|.|..        |..|
  Rat  2071 QLRGSFDGCRAPYSLDAEDLADYGEGWNASAHNSSDGFPKVWQYQSQSRRRGYPTW--------- 2126

  Fly   271 NLLMGINHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANT 335
                     |.:..| ...||.|.|......:.:|:.:|....||||.|.|||::|::|||:.|.
  Rat  2127 ---------GKLAVY-GGGGYVVPLGTDHQSASRILQHLFDNRWLDALTRALFVEFTVYNANVNL 2181

  Fly   336 FTVCTLWVEKFPYQYPDGHTRIESHTFVEQLREFTKFGMLMVFVFVVTWLQFTKAFFLKVWYDPR 400
            ....||.:|      ..|.....||..::.||.:........||.|...:.|...|:..|.....
  Rat  2182 LCCVTLTLE------TSGLGTFFSHVTLQSLRLYPFTDGWHPFVVVAELVYFLFLFYYMVEQGKL 2240

  Fly   401 QLKTLWVQVDAMIVALSLVVGMIMSVRDNLVQ---------KMIKSVEIAVVVD----------- 445
            ..|..|              |...| :.||::         .::..|:.||:.|
  Rat  2241 MRKQKW--------------GYFCS-KWNLLELAIILASWSALVVFVKRAVLADRDLQHYRKNRG 2290

  Fly   446 -FLDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVITVIFI 509
             .:.|.|.|........:....|.|.|::||.:|:.:....:.|..:..||..:.....:.:|.:
  Rat  2291 EGVSFSETAAADAALGYIIAFLVLLSTVKLWHLLRLNPKMNMITSALRSAWGDISGFVTVILIML 2355

  Fly   510 IAIGIATVTING----NYTSNFRDFPKGIVTVTCFAFGYTNLV-YPPDIFYGGEWLGILL----Y 565
            :|..||:..|.|    :|.:.| |..:.::::....|.|..:: |.|       .||.||    .
  Rat  2356 LAYSIASHLIFGWKLRSYKTLF-DAAETMISLQLGIFNYEEVLDYSP-------VLGSLLIGSCI 2412

  Fly   566 TIMGFVVKYMLINLIVSMMRDQMASVKADRDKKVRQRITFWQFLRVEYAHFINYIVKVFHCQKGY 630
            ..|.|||..:.|::|:....::..|.:...:.::.      ..|.::...|:.     ..|
  Rat  2413 VFMTFVVLNLFISVILVAFSEEQKSDQLSEEGEIA------DLLLMKILSFLG-----IRC---- 2462

  Fly   631 QRKNRTVAQNIQRKLNSNEL 650
             ::..|.:.:.|.:|:.|.|
  Rat  2463 -KREETWSSSEQPELSPNTL 2481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	Polycystin_dom	167..363	CDD:466668	53/220 (24%)
		PKD_channel	364..591	CDD:462341	53/256 (21%)
Pkd1l2	XP_038954049.1	CLECT	70..186	CDD:153057
		Gal_Rha_Lectin_PKD1L2	189..285	CDD:438688
		REJ	<697..894	CDD:366875
		GPS	1308..1347	CDD:460350
		PLAT_polycystin	1418..1537	CDD:238850
		Polycystin_dom	2013..2209	CDD:466668	55/226 (24%)
		PKD_channel	2211..2433	CDD:462341	51/244 (21%)