Protein Alignment brv1 and pkd2l1

DIOPT Version :9

• Sequence 1: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: XP_695404.3
• Gene: pkd2l1 / 567026
• ZFINID: ZDB-GENE-030616-558
• Length: 805
• Species: Danio rerio
• Alignment Length: 649
• Identity: 144/649 - (22%)
• Similarity: 260/649 - (40%)
• Gaps: 111/649 - (17%)

  Fly   111 NERVNLKYRLITEELWLTGKLFLVYFFMALAFFDELLYFNTEATELLFQCNHGDAFGLLSVGDVP 175
            |.:.||| .|:...::|.....|.|...:.|.:    |:....|:|.......:.....|:|.:.
Zfish   103 NVKANLK-ELLIYIVFLVDLCLLTYGMTSSATY----YYTKAMTDLFVNLPGSNGMSFSSIGCMN 162

  Fly   176 DIYFFVVSSLV--LAFTDGKN----TSGGAPWIHAEGTRLLGVVRLRQLRTESNRLGLSLPVFTE 234
            |::.::...|:  |.:|...|    .:|...:|:.|.. ||||.|:|||:.:.|  ...:|...:
Zfish   163 DVWTYMEGPLLDNLYWTKWYNDEPLENGNQSFIYYENL-LLGVPRVRQLKVKQN--SCKVPTDFK 224

  Fly   235 RDFSESWTLPYERVPYTDKYWPIY--TPWLPSVSVARDNLLMGINHVGHMFNYPESKGYKVLLSD 297
            ::.|:.:.: |......|..:.:.  |.|    ....:..:.|.:|.|.:..| ...|:...|:.
Zfish   225 KEISDCFDV-YNIKKEDDGAFGLINGTAW----QYHSEKEIKGSSHWGLLTTY-SGAGFYQDLTT 283

  Fly   298 TRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFTVCTLWVEKFPYQYPDGHTRIESHTF 362
            ||.:|..:::.|.:..|||..|..||:||:.|||:.|.|.|..|.||     :|.....|.|:..
Zfish   284 TRDESAALLEDLRENLWLDRGTRVLFIDFTAYNANINLFCVIRLVVE-----FPATGGAIPSYQI 343

  Fly   363 --VEQLREFTKFGMLMV---FVFVVTWLQFTKAFFLKV-WYDPRQLKTLWVQVDAMIVALSLVVG 421
              |:.:|..|.:...::   .||.|..|.:.....|:. .:......::|..:|.:::.|::|..
Zfish   344 RTVKLIRYVTTWDYFIIGCEIVFCVFILYYIVEEILEFRIHKLSHFTSIWNILDIVVILLAVVAI 408

  Fly   422 MIMSVR----DNLVQKMIKSVEIAVVVDFLDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFSA 482
            :..:.|    |.|:..::|..:|....:||.|   .|..|.......|..|.:  :::|.:.|:.
Zfish   409 VFSAFRTIKVDGLLGNLLKQPDIYADFEFLAF---WQTQYNNMNAVNLFFAWI--KIFKYISFNK 468

  Fly   483 TFQLFTKTIAMAWDALLCTFVITVIFII---AIGIATVTINGNYTSNFRDFPKGIVT---VTCFA 541
            |....|.|:|.   ..|..|...::|.|   |.......:.|.....|..|.|.|.|   :....
Zfish   469 TMTQLTSTLAR---CALDIFGFAIMFFIVFFAYAQLGYLLFGTEVETFSTFNKCIFTQFRIILGD 530

  Fly   542 FGY-----TNLVYPPDIFYGGEWLGILLYTIMGFVVKYMLINLIVSMMRDQMASVKADRDKKVRQ 601
            |.|     .|.|..|..|:.        |.   |.|.::|:|:.::::.|..:.||::...: :.
Zfish   531 FDYDAIDRANRVLGPIYFFS--------YV---FFVFFVLLNMFLAIINDTYSEVKSELASQ-KD 583

  Fly   602 RITFWQFLRVEYAHFINYIVKVFHCQKGYQRKNRTVAQNIQRKLNSNELKRRKTKISSIYSETIY 666
            .......::..||       |.|                       .:||.:|.|||.:..
Zfish   584 EFQIADLIKQSYA-------KTF-----------------------MKLKLKKEKISDVQK---- 614

  Fly   667 VMPIDKDLEQMKYRERIERTF--TLAAILHTQMELMERLMFGDEEGNLPSLDQEDEQVPETEED 728
              .:|....::::::     |  .|..:.|:..|:.......|::||.....||.|.:.:..|:
Zfish   615 --ALDSGASELEFKD-----FRNALKEMGHSDREISAAFSKFDQDGNQTLDKQEQENMKQELEE 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	108/454 (24%)
pkd2l1	XP_695404.3	PKD_channel	153..574	CDD:285288	108/453 (24%)
		UPF0118	358..>499	CDD:294317	32/148 (22%)
		DegS	566..>691	CDD:283127	25/148 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46093
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820