Protein Alignment brv1 and pkd2l1

DIOPT Version :10

• Sequence 1: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: XP_695404.4
• Gene: pkd2l1 / 567026
• ZFINID: ZDB-GENE-030616-558
• Length: 862
• Species: Danio rerio
• Alignment Length: 649
• Identity: 144/649 - (22%)
• Similarity: 260/649 - (40%)
• Gaps: 111/649 - (17%)

  Fly   111 NERVNLKYRLITEELWLTGKLFLVYFFMALAFFDELLYFNTEATELLFQCNHGDAFGLLSVGDVP 175
            |.:.||| .|:...::|.....|.|...:.|.:    |:....|:|.......:.....|:|.:.
Zfish   160 NVKANLK-ELLIYIVFLVDLCLLTYGMTSSATY----YYTKAMTDLFVNLPGSNGMSFSSIGCMN 219

  Fly   176 DIYFFVVSSLV--LAFTDGKN----TSGGAPWIHAEGTRLLGVVRLRQLRTESNRLGLSLPVFTE 234
            |::.::...|:  |.:|...|    .:|...:|:.|.. ||||.|:|||:.:.|  ...:|...:
Zfish   220 DVWTYMEGPLLDNLYWTKWYNDEPLENGNQSFIYYENL-LLGVPRVRQLKVKQN--SCKVPTDFK 281

  Fly   235 RDFSESWTLPYERVPYTDKYWPIY--TPWLPSVSVARDNLLMGINHVGHMFNYPESKGYKVLLSD 297
            ::.|:.:.: |......|..:.:.  |.|    ....:..:.|.:|.|.:..| ...|:...|:.
Zfish   282 KEISDCFDV-YNIKKEDDGAFGLINGTAW----QYHSEKEIKGSSHWGLLTTY-SGAGFYQDLTT 340

  Fly   298 TRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFTVCTLWVEKFPYQYPDGHTRIESHTF 362
            ||.:|..:::.|.:..|||..|..||:||:.|||:.|.|.|..|.||     :|.....|.|:..
Zfish   341 TRDESAALLEDLRENLWLDRGTRVLFIDFTAYNANINLFCVIRLVVE-----FPATGGAIPSYQI 400

  Fly   363 --VEQLREFTKFGMLMV---FVFVVTWLQFTKAFFLKV-WYDPRQLKTLWVQVDAMIVALSLVVG 421
              |:.:|..|.:...::   .||.|..|.:.....|:. .:......::|..:|.:::.|::|..
Zfish   401 RTVKLIRYVTTWDYFIIGCEIVFCVFILYYIVEEILEFRIHKLSHFTSIWNILDIVVILLAVVAI 465

  Fly   422 MIMSVR----DNLVQKMIKSVEIAVVVDFLDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFSA 482
            :..:.|    |.|:..::|..:|....:||.|   .|..|.......|..|.:  :::|.:.|:.
Zfish   466 VFSAFRTIKVDGLLGNLLKQPDIYADFEFLAF---WQTQYNNMNAVNLFFAWI--KIFKYISFNK 525

  Fly   483 TFQLFTKTIAMAWDALLCTFVITVIFII---AIGIATVTINGNYTSNFRDFPKGIVT---VTCFA 541
            |....|.|:|.   ..|..|...::|.|   |.......:.|.....|..|.|.|.|   :....
Zfish   526 TMTQLTSTLAR---CALDIFGFAIMFFIVFFAYAQLGYLLFGTEVETFSTFNKCIFTQFRIILGD 587

  Fly   542 FGY-----TNLVYPPDIFYGGEWLGILLYTIMGFVVKYMLINLIVSMMRDQMASVKADRDKKVRQ 601
            |.|     .|.|..|..|:.        |.   |.|.::|:|:.::::.|..:.||::...: :.
Zfish   588 FDYDAIDRANRVLGPIYFFS--------YV---FFVFFVLLNMFLAIINDTYSEVKSELASQ-KD 640

  Fly   602 RITFWQFLRVEYAHFINYIVKVFHCQKGYQRKNRTVAQNIQRKLNSNELKRRKTKISSIYSETIY 666
            .......::..||       |.|                       .:||.:|.|||.:..
Zfish   641 EFQIADLIKQSYA-------KTF-----------------------MKLKLKKEKISDVQK---- 671

  Fly   667 VMPIDKDLEQMKYRERIERTF--TLAAILHTQMELMERLMFGDEEGNLPSLDQEDEQVPETEED 728
              .:|....::::::     |  .|..:.|:..|:.......|::||.....||.|.:.:..|:
Zfish   672 --ALDSGASELEFKD-----FRNALKEMGHSDREISAAFSKFDQDGNQTLDKQEQENMKQELEE 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	Polycystin_dom	167..363	CDD:466668	55/205 (27%)
		PKD_channel	364..591	CDD:462341	52/245 (21%)
pkd2l1	XP_695404.4	None