DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brv1 and pkd1l3

DIOPT Version :9

Sequence 1:	NP_649116.1	Gene:	brv1 / 40116	FlyBaseID:	FBgn0036874	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_021333660.1	Gene:	pkd1l3 / 565944	ZFINID:	ZDB-GENE-060810-132	Length:	758	Species:	Danio rerio

Alignment Length:	584	Identity:	104/584 - (17%)
Similarity:	183/584 - (31%)	Gaps:	204/584 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 DAFGLLSVGDVPDIYFFVVSSLV------LAFT----DGKNTSG-----------GAPWI----- 202
            :.|.:.|..::.|....||.:.|      |:||    :|.|.|.           |..|:
Zfish    71 NGFAVTSTFNITDANVTVVVTAVPNRNISLSFTLHPPNGTNISSWNQSTTVTYKDGYRWLINPDM 135

  Fly   203 --HAEGTRLLGVVRLRQLRTESNRLGLSLPVFTERDFSESWTLPYERVPYTDK-YWPIYTPWLPS 264
              ..:||..:.|  |....|.|:.|...:.||..:..  .|.        ||. .|
Zfish   136 RKELDGTWKVSV--LPTSYTSSDVLTFKMSVFVTKCL--FWD--------TDNGQW--------- 179

  Fly   265 VSVARDNLLMGIN---HVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLD-ANTTALFMD 325
               :|:..::|.|   ::.|..              ..|.:.....:.:..|.:| :.|.|||..
Zfish   180 ---SREGCMVGPNTMPNLTHCL--------------CNHTTFFGSSFFVMPNQVDLSKTAALFAT 227

  Fly   326 --------------FSLYNADANTFTVCTLWVEKFPYQYPDGHT-RIESHTFVEQLREFTKFGML 375
                          |:||       .:..:|.     .|.|... |....|.:|......::..|
Zfish   228 VNENYIVVVVLSCFFALY-------LILVMWA-----WYADRKALRTRKMTLLEDNHPCAQYNYL 280

  Fly   376 M-----------VFVFVVTWLQFTKAFFLKVWYDPRQL----KTLWVQ--VDAMIVALSLVVGMI 423
            :           ....:...|||.:.     ..|...|    |.::.:  ||..::::...:|.:
Zfish   281 VNVQTGHRRKAGTTAKIKVMLQFAEG-----QSDSYSLSDSEKPVFERGGVDVFLLSMPFSLGEL 340

  Fly   424 MSV---RDN--------LVQKMIKSVEIAVVVDFL--------------DFREPAQLAYLEDVV- 462
            .|:   .||        |.:.||:.::...|..||              :..:..::|...::.
Zfish   341 QSIDISHDNSGGSPDWYLDKVMIQDLQTQDVSHFLCSTWLRGETCKRTFNSAKKNEIASFGNIFQ 405

  Fly   463 TGLAVALVTMRLWKVLQFSATFQLFTKT--IAMAWDALLCTFVITVIF-----------IIAIGI 514
            |..:.......:|..:........||:.  ::.....||||..|.::|           |:.|
Zfish   406 TRTSSGFRDEHIWVSIVDPPRRSPFTRVQRVSCCMSLLLCTMAINIMFWNLPTDAESPVILKI-- 468

  Fly   515 ATVTINGNYTSNFRDFPKGIVTVTCFAFGYTNLVYPPDIFYGGEWLGILLYTIMGFVVKYMLINL 579
                  |::...::.|   :|.|....|     ::|         :.||:.||...:...:|:|
Zfish   469 ------GSFQLTWQQF---MVAVESGLF-----MFP---------INILIITIFRHIKPRILLN- 509

  Fly   580 IVSMMRDQMASVKADRDKKVRQRITF-WQFLRVEYAHFINYIVKVFHCQKGYQRKNRTVAQNIQ 642
                      ..|.|..||.....:. ...:..|....:||:.|        ..||...|:.||
Zfish   510 ----------KGKTDSSKKTTPAASVSMNTIIQETVGLLNYLSK--------SPKNNLPAKEIQ 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	91/529 (17%)
pkd1l3	XP_021333660.1	GPS	167..214	CDD:321989	9/82 (11%)
pkd1l3	XP_021333660.1	PLAT_polycystin	277..392	CDD:238850	19/119 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010