Protein Alignment brv1 and pkd1b

DIOPT Version :10

• Sequence 1: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: XP_021335980.1
• Gene: pkd1b / 565697
• ZFINID: ZDB-GENE-100707-2
• Length: 4007
• Species: Danio rerio
• Alignment Length: 822
• Identity: 145/822 - (17%)
• Similarity: 279/822 - (33%)
• Gaps: 247/822 - (30%)

  Fly     8 IIFYLTLIIIAICVACIWMFSGFRHEYGKFNMILVAFLAVTLLQILIFTPIKFTIMSLDAAFWPA 72
            ::..|..:::..|:|.:.:: |.........|.||:.|:..|...|:..|:...|.:|..|....
Zfish  3164 MVHLLVAVLLGTCLAVVGLY-GSSFTSSVVLMWLVSTLSAVLTSALLLEPLAICIQALYLATVVR 3227

  Fly    73 HQAPETPDENA-------NVDTFMDNLR--------------LRLRTLRS--------------E 102
            ...||..:..|       :.:.|.|.:.              .:|||||:              .
Zfish  3228 PVDPEVEERLAQETEVRRSEEDFRDKVHPLCGYGLLQAKEEARKLRTLRALMRSCLVYMLFLLVV 3292

  Fly   103 LMIT-ERH------RNERVNLKYRLITEELWLTGKLFLVYFFMALAFFDEL----LYFN------ 150
            ||:. :.|      |.....:|:.||:......|.:.|..:..|..:.:|.    ||.|
Zfish  3293 LMVNYQEHVQMADSRRLHSAIKHTLISASAGKPGLMKLSGWMNAEQWINEKLTSHLYENPSLLLT 3357

  Fly   151 --TEATELLFQ--CNHG--DAF--GLLSVGDVPDIYFFVVSSLVLAFTDGKNTSGGAPWIHAEGT 207
              ....::.||  |:.|  |.|  |.||:  :|..:   |||..   ..|:.||..    |::.|
Zfish  3358 GPARLQKVYFQDFCSQGIRDQFQSGRLSL--MPTAH---VSSHA---NPGQQTSTA----HSKNT 3410

  Fly   208 RLLGVVRLRQLRTESNRLGLSLPVFTERDFSESWTLPYERVPYTDKYWPIYTPWLPSVSVARDNL 272
            ..|...:.|.|..                ||::                             :.|
Zfish  3411 PALSTWQKRALCA----------------FSQT-----------------------------EEL 3430

  Fly   273 LMGINHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFT 337
            ::|.|          ::..:.:|||           |.|:.|:...|.|:.::|:.|:...:...
Zfish  3431 VLGNN----------TEYTRQILSD-----------LQKEKWMTTGTKAVLIEFTQYHKQTSILA 3474

  Fly   338 VCTLWVEK-----------------FPYQYPDGHTRIESHTFVEQLREFTKFGMLMVFVFVVTWL 385
            ..::.:::                 .|...||.|..:                .:::.:|.:.:|
Zfish  3475 PVSILLDQTQTGRILAFISIQPFHISPLSGPDLHVTL----------------TVVLLLFALCFL 3523

  Fly   386 QF-TKAFFLKVWYDPRQ-LKTLWVQVDAMIVALSLVVGMIMSVRDNLVQKMIKSVEI----AVVV 444
            .. .:|...|    |.| |:..|.....::..|:|...::     .|......:|.|    ::..
Zfish  3524 STEVRALIRK----PSQYLRQAWCWFQTLLALLALAAAVL-----RLYFLYTTTVCISRYRSIPS 3579

  Fly   445 DFLDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDAL--LC--TFVIT 505
            .|.||...|.:|...:.::.:.:.|:.:::..:|||...:.:..:.|   |...  :|  .|::.
Zfish  3580 SFADFHSAATVARKSNQLSAILLTLLALKMVGILQFVRRWLVMGRVI---WQVFPQICGVVFLLL 3641

  Fly   506 VIFIIAIGIATVTINGNYTSNFRDFPKGIVTVTCFAFGYTNL--------VYPPDIFYGGEWLGI 562
            ::.::...|..:..:|: ...||...:...::.|...|.|.|        |..|........:|
Zfish  3642 LLLLLFSHIGMMLFSGS-VEGFRTLGQASSSLLCLLRGRTGLQRLCEHHPVVGPLYCLSAVGIG- 3704

  Fly   563 LLYTIMGFVVKYMLINLIVSMMRDQMASVKADRDKKVRQ----RITFWQFL--RVEYAHFINYIV 621
              :.::|.:...:||.....:..|........:|.::.|    |:..|..|  ..|:.|.:.
Zfish  3705 --FWVLGRLCAAVLIRTYQMVQADIYRPSMEPQDYEMVQFLIKRLKLWMGLSKTKEFRHRVK--- 3764

  Fly   622 KVFHCQKGYQRKNRTVAQNIQRKLNSN------ELKRRKTKISSIYSETIYVMPIDKDLEQMKYR 680
                    ::......:::.|...:||      .:..|:|.:||..|.......|....:...|.
Zfish  3765 --------FEGMRPPPSRSSQVSASSNCWTPLSPIGSRQTLLSSASSLASDTSVISDSCDVHPYV 3821

  Fly   681 ERIERTFTLAAILHTQMELMERLMFGDEEGNLPSLDQEDEQV 722
            ||:             :..::.|:.|.|..|     |..|:|
Zfish  3822 ERL-------------VPCVDSLLAGFERVN-----QVTEEV 3845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	Polycystin_dom	167..363	CDD:466668	34/212 (16%)
		PKD_channel	364..591	CDD:462341	41/244 (17%)
pkd1b	XP_021335980.1	PCC	25..2314	CDD:188093
		GPS	2590..2636	CDD:470616
		PLAT_polycystin	2697..2815	CDD:238850
		PKD_channel	3513..3720	CDD:462341	40/222 (18%)