Protein Alignment brv1 and Pkd2l2

DIOPT Version :9

• Sequence 1: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: XP_017173433.1
• Gene: Pkd2l2 / 53871
• MGIID: 1858231
• Length: 623
• Species: Mus musculus
• Alignment Length: 680
• Identity: 147/680 - (21%)
• Similarity: 260/680 - (38%)
• Gaps: 167/680 - (24%)

  Fly   106 TERHRNERVNLKYRLITEELWLTGKLFLVYFFM----ALAF---FDELLYFNTEATELLFQCNHG 163
            |.:|     :|.||...|......:|.|.:.|:    .|.|   ...:.|.|...:.|....:..
Mouse    14 TSKH-----DLHYRREAEVNTTLEELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFVDTSLP 73

  Fly   164 D--AFGLLSVGDVPDIYFFVVSSLVLAFTDG---------------KNTSGGAPWIHAEGTRLLG 211
            |  .....|:..:.:.:.|:...|:    ||               ||:|.    |:.|.. |||
Mouse    74 DDERSSFRSIRSITEFWKFMEGPLI----DGLYWDSWYGNKQLYSVKNSSR----IYYENV-LLG 129

  Fly   212 VVRLRQLRTESNRLGLSLPVF-------------TERDFSE-------SWT-LPYERVPYTDKYW 255
            :.|:||||..:|...: .|.|             ...|||:       .|| .|..|.
Mouse   130 IPRVRQLRVRNNTCKV-YPAFQSLVSDCYSKYTVENEDFSDFGLKRNPEWTHTPSSRT------- 186

  Fly   256 PIYTPWLPSVSVARDNLLMGINHVGHMFNYPESKGYKVLLSDTRHKS-LKIIDYLMKKNWLDANT 319
               .||                |.|.:..|.:. ||.|.||.::.:: .|.:| |...||:...|
Mouse   187 ---APW----------------HWGFVGVYRDG-GYIVTLSKSKSETKAKFVD-LRLNNWISRGT 230

  Fly   320 TALFMDFSLYNADANTFTVCTLWVEKFPYQYPDGHTRIESHTF--VEQLREFTKFG--------- 373
            .|:|:|||||||:.|.|.:..|..|     :|.....:.|..|  |:.||..:.:.
Mouse   231 RAVFIDFSLYNANVNLFCIIRLLAE-----FPATGGLLTSWQFYSVKLLRYVSYYDYFIASCEVI 290

  Fly   374 -MLMVFVFVVTWL----QFTKAFFLKVWYDPRQLKTLWVQVDAMIVALSLVVGMIMSVRDN---- 429
             .:.:|||::..|    :|..|:|..||.        |::   |::.|...:.:......|
Mouse   291 FCIFLFVFIIQELRKVNEFKSAYFRSVWN--------WLE---MLLLLLCFLAVSFYAYCNMQSF 344

  Fly   430 -LVQKMIKSVEIAVVVDFLDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAM 493
             |:.:::|:.:     .:.||...|......:.|..:.:....::::|.:.|:.|....:.|::.
Mouse   345 LLLGQLLKNTD-----SYPDFYFLAYWHIYYNNVIAITIFFAWIKIFKFISFNETMSQLSSTLSR 404

  Fly   494 AWDALLCTFVITVIFIIAIGIATVTINGNYTSNFRDFPKGIVTVTCFAFGYTNLVYPPDIFYG-- 556
            ....::...::..|...|.......:.|:...:|..|...|       |....:|.....|.|
Mouse   405 CMKDIVGFAIMFFIIFSAYAQLGFLVFGSQVDDFSTFQNSI-------FAQFRIVLGDFNFAGIQ 462

  Fly   557 -GEW-LGILLYTIMGFVVKYMLINLIVSMMRDQMASVKADRDKKVRQRITFWQFLRVEYAHFINY 619
             ..| ||.:.:....|.|.::|:|:.::::.|..:.|||  |..:.:|..| :..::......|.
Mouse   463 QANWILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKA--DYSIGRRPDF-ELGKIIQKSCFNV 524

  Fly   620 IVKVFHCQKGYQRKNRTVAQNIQRKLNSNELKRRKTKISSIYSETIYVMPIDKDLEQMK-YRERI 683
            :.|:        |..:..|:. ::|:.:.:|.:|..:.....||.       ::.|||| ::||:
Mouse   525 LEKL--------RLKKAQAKE-EKKMQTTDLAQRARRDGFDESEI-------QEAEQMKRWKERL 573

  Fly   684 ERTFTLAAILH-----TQMELMERLMFGDE 708
            |:.:....|..     ||.|..|..::..|
Mouse   574 EKKYYSTEIQDDYQPVTQQEFRELFLYAVE 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	104/487 (21%)
Pkd2l2	XP_017173433.1	PKD_channel	78..499	CDD:369653	104/486 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5820
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760