DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv1 and PKD2

DIOPT Version :9

Sequence 1:	NP_649116.1	Gene:	brv1 / 40116	FlyBaseID:	FBgn0036874	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_000288.1	Gene:	PKD2 / 5311	HGNCID:	9009	Length:	968	Species:	Homo sapiens

Alignment Length:	743	Identity:	175/743 - (23%)
Similarity:	295/743 - (39%)	Gaps:	171/743 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 QAPETPDENANVDTFMDNLRLR---------------LRTLRSELMITERHRNERVNLK---YRL 120
            |.|..|......|....:|.|.               ||.|....::.|...|....||   ..|
Human   160 QGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLREL 224

  Fly   121 ITEELWLTGKLFLVYFFMALAFFDELLYFNTEATELLF---QCNHGDAFGLLSVGDVPDIYFFVV 182
            :|..|:|.....|.|..|:     ..:|:.|.....||   ..:..:.....::..:.|.:.|..
Human   225 VTYLLFLIVLCILTYGMMS-----SNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTE 284

  Fly   183 SSLVLAF---------TDGKNTSGGAPWIHAEGTRLLGVVRLRQLRTESNRLGLSLPVFTERDFS 238
            .||:...         |:..|.|    :|..|.. ||||.|:||||..:.  ..|:|.....:..
Human   285 GSLLDGLYWKMQPSNQTEADNRS----FIFYENL-LLGVPRIRQLRVRNG--SCSIPQDLRDEIK 342

  Fly   239 ESWTL----PYERVPYTDK---YWPIYTPWLPSVSVARDNLLMGINHVGHMFNYPESKGYKVLLS 296
            |.:.:    ..:|.|:..:   .| |||         .:..|.|.:|.|.:..| ...||.:.||
Human   343 ECYDVYSVSSEDRAPFGPRNGTAW-IYT---------SEKDLNGSSHWGIIATY-SGAGYYLDLS 396

  Fly   297 DTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFTVCTLWVEKFPYQYPDGHTRIESHT 361
            .||.::...:..|.|..|||..|.|.|:|||:|||:.|.|.|..|.||     :|.....|.|..
Human   397 RTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVE-----FPATGGVIPSWQ 456

  Fly   362 F--VEQLREFTKFGMLM-----VFVFVVTWLQFTKAFFLKVWYDPRQLKTLWVQVDAMIVALSLV 419
            |  ::.:|..|.|...:     :|.|.:.:....:...::: :.....::.|..:|.:||.||:|
Human   457 FQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRI-HKLHYFRSFWNCLDVVIVVLSVV 520

  Fly   420 -VGMIMSVRDNLVQKMIKSVEIAVVVDFLD----FREPAQLAYLE---DVVTGLAVALVTMRLWK 476
             :|:          .:.::..:.|::.||:    |.....|||.:   :.:..:.|..|.::|:|
Human   521 AIGI----------NIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFK 575

  Fly   477 VLQFSATF-QLFTKTIAMAWDALLCTFVITVIFIIAIGIATVT--INGNYTSNFRDFPKGIVTVT 538
            .:.|:.|. ||.|.....|.|  |..|.| :.|||.:..|.:.  :.|....:|..|.:.|.|..
Human   576 FINFNRTMSQLSTTMSRCAKD--LFGFAI-MFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQF 637

  Fly   539 CFAFGYTNLVYPPDIFYGGEWLGILLYTIMGFVVKYMLINLIVSMMRDQMASVKADRDKKVRQRI 603
            ....|..|..   :|......||.:.:|...|.:.::|:|:.::::.|..:.||:|..:
Human   638 RIILGDINFA---EIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQ------ 693

  Fly   604 TFWQFLRVEYAHFINYIVKVFHCQKGYQR-------KNRTV---AQNIQR---KLNSNELKR--- 652
               |...:|.:..|         :|||.:       |..||   ::::::   |||.:||::
Human   694 ---QKAEMELSDLI---------RKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQDLK 746

  Fly   653 ----RKTKISSIYSETIYVMPIDKDL---EQMKYRERIERTFTLAAILHTQMELMERLMFGDEEG 710
                ...:|.:|:  |.|....|::|   |..:.|:.:|:               ||.....:..
Human   747 GKGHTDAEIEAIF--TKYDQDGDQELTEHEHQQMRDDLEK---------------EREDLDLDHS 794

  Fly   711 NLP----------SLDQEDEQVPETEED 728
            :||          |||..:|   :.:||
Human   795 SLPRPMSSRSFPRSLDDSEE---DDDED 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	115/459 (25%)
PKD2	NP_000288.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..181		5/20 (25%)
		PKD_channel	269..687	CDD:400395	115/457 (25%)
		Selectivity filter. /evidence=ECO:0000305\|PubMed:28092368	641..643		0/1 (0%)
		EFh_HEF	<724..792	CDD:355006	16/84 (19%)
		EF-hand motif	754..782	CDD:320075	8/29 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..831		15/74 (20%)
		Linker. /evidence=ECO:0000305\|PubMed:18694932	803..822		6/20 (30%)
		Important for interaction with PACS1 and PACS2. /evidence=ECO:0000269\|PubMed:15692563	810..821		4/13 (31%)
		Fer4_24	834..868	CDD:407943
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	917..968
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810