DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv1 and PKD1

DIOPT Version :9

Sequence 1:	NP_649116.1	Gene:	brv1 / 40116	FlyBaseID:	FBgn0036874	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_024306066.1	Gene:	PKD1 / 5310	HGNCID:	9008	Length:	4343	Species:	Homo sapiens

Alignment Length:	674	Identity:	136/674 - (20%)
Similarity:	246/674 - (36%)	Gaps:	159/674 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LTLIIIAICVACI-WMFSGFRHEYGKFNMILVAFL----AVTLLQILIFTPIKFTIMSLDAAFWP 71
            |:|:::|:.||.. |:.:.|...      :.||:|    |..|...|.:.|:|   :.|:|.::.
Human  3601 LSLLLVAVAVAVSGWVGASFPPG------VSVAWLLSSSASFLASFLGWEPLK---VLLEALYFS 3656

  Fly    72 AHQAPETPDENANVDTFMDNLRL--------RLRTLRSELMITERHRNERVNLKYRLITEELWLT 128
            .......|||:   ||.:::..:        |:|......:...:....:|...:.::
Human  3657 LVAKRLHPDED---DTLVESPAVTPVSARVPRVRPPHGFALFLAKEEARKVKRLHGML------- 3711

  Fly   129 GKLFLVYFFMALAFFDELLYFNTEATELLFQCNHGDAFGLLSVGDVPDIYFFVVSSLVLAFTDGK 193
             :..|||....|.   .||....:|:     | ||.|:.|.|.     |...:.|...||.|..:
Human  3712 -RSLLVYMLFLLV---TLLASYGDAS-----C-HGHAYRLQSA-----IKQELHSRAFLAITRSE 3761

  Fly   194 NTSGGAPW--------IHA-EGTRLLGVVRLRQLRTES--------------NRLGLSLPVFTER 235
            ..   .||        :|. :.:..||..||||:|.:.              :..|    .|:..
Human  3762 EL---WPWMAHVLLPYVHGNQSSPELGPPRLRQVRLQEALYPDPPGPRVHTCSAAG----GFSTS 3819

  Fly   236 DFSESWTLPYERVPYTDKYWPIYTPWLPSVSVARDNLLMGINHVGHMFNYPESKGYKVLLSDTRH 300
            |:...|..|:.    ....|....|         |  |:|....|....| :|.||...|..:..
Human  3820 DYDVGWESPHN----GSGTWAYSAP---------D--LLGAWSWGSCAVY-DSGGYVQELGLSLE 3868

  Fly   301 KSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFTVCTLWVEKFPYQYPDGHTRIESHTFVEQ 365
            :|...:.:|...||||..:.|:|::.:.|:.........||.:|     :|.....:.:.:
Human  3869 ESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLE-----FPAAGRALAALS---- 3924

  Fly   366 LREFT----KFGMLMVFVFVVTWLQFTKAFFL---KVWYDPRQLKTL-------WVQVDAMIVAL 416
            :|.|.    ..|:.:..:..|..|.|...|.:   :.|:...:.:.|       |:.| |:..|.
Human  3925 VRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTWHREGRWRVLRLGAWARWLLV-ALTAAT 3988

  Fly   417 SLVVGMIMSVRDNLVQKMIKSVEIAVVVDFLDFREPAQLAYLEDVVTGLAVALVTMRLWKV---L 478
            :||....:...|....:.::.....    |..|.:.|||:   ....|||.:|:.:.|.|.   |
Human  3989 ALVRLAQLGAADRQWTRFVRGRPRR----FTSFDQVAQLS---SAARGLAASLLFLLLVKAAQQL 4046

  Fly   479 QFSATFQLFTKTIAMAWDALLCTFVITVIFIIAIGIATVTINGNYTSNFRDFPKGIVTVTCFAFG 543
            :|...:.:|.||:..|...||...:..|:..:|.....:.:..:...:.....:.:: |.|...|
Human  4047 RFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCVDSLWSVAQALL-VLCPGTG 4110

  Fly   544 YTNLVYPPDIFYGGEWLGILLYTI-------MGFVV--------------------KYMLINLIV 581
            .:.|. |.:.::....|.:.|:.:       :|.|:                    .|.::.|.:
Human  4111 LSTLC-PAESWHLSPLLCVGLWALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFL 4174

  Fly   582 SMMRDQMASVKADRDKKVRQRITF 605
            ..:|..|...|.   |:.|.::.|
Human  4175 RRLRLWMGLSKV---KEFRHKVRF 4195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	97/492 (20%)
PKD1	XP_024306066.1	LRR	<50..>126	CDD:227223
		leucine-rich repeat	70..92	CDD:275378
		leucine-rich repeat	93..116	CDD:275378
		PCC	97..2768	CDD:188093
		leucine-rich repeat	117..129	CDD:275378
		GPS	3051..3100	CDD:197639
		PLAT_polycystin	3158..3277	CDD:238850
		PKD_channel	3751..4153	CDD:332708	89/443 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820