Protein Alignment brv1 and Pkd2

DIOPT Version :10

• Sequence 1: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: NP_001178863.1
• Gene: Pkd2 / 498328
• RGDID: 1559992
• Length: 966
• Species: Rattus norvegicus
• Alignment Length: 768
• Identity: 174/768 - (22%)
• Similarity: 291/768 - (37%)
• Gaps: 219/768 - (28%)

  Fly     8 IIFYLTLIIIAICVACIWMFSGFRHEYGKFNMILVAFLAVTLLQILIFTPIKFTIMSLDAAFWPA 72
            ::.||..:|: :|:....|.|...:.|.:           ||.|:.|.||:.
  Rat   222 LVTYLFFLIL-LCILTYGMMSSNVYYYTR-----------TLSQLFIDTPVS------------- 261

  Fly    73 HQAPETPDENANVDTFMDNLRLRLRTLRSELMITERHRNERVNLKYRLITEELWLTGKLFLVYFF 137
                                                 :.|:.|.|.....|:.|.         |
  Rat   262 -------------------------------------KTEKTNFKTLSSMEDFWK---------F 280

  Fly   138 MALAFFDELLYFNTEATELLFQCNHGDAFGLLSVGDVPDIYFFVVSSLVLAFTDGKNTSGGAPWI 202
            ...:|.|. ||:..:::      ||                           |...|.|    :|
  Rat   281 TEGSFLDG-LYWKAQSS------NH---------------------------TQADNRS----FI 307

  Fly   203 HAEGTRLLGVVRLRQLRTESNRLGLSLPVFTERDFSESWTL----PYERVPYTDK---YWPIYTP 260
            ..|.. ||||.||||||..:.  ..|:|.....:..|.:.:    ..:|.|:..:   .| |||
  Rat   308 FYENL-LLGVPRLRQLRVRNG--SCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAW-IYT- 367

  Fly   261 WLPSVSVARDNLLMGINHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMD 325
                    .:..|.|.:|.|.:..| ...||.:.||.||.::...:..|.:..|||..|.|.|:|
  Rat   368 --------SEKDLNGSSHWGIIATY-SGAGYYLDLSRTREETAAQLAGLRRNFWLDRGTRAAFID 423

  Fly   326 FSLYNADANTFTVCTLWVEKFPYQYPDGHTRIESHTF--VEQLREFTKFGMLM-----VFVFVVT 383
            ||:|||:.|.|.|..|.||     :|.....:.|..|  |:.:|..|.|...:     :|.|.:.
  Rat   424 FSVYNANINLFCVVRLLVE-----FPATGGVVPSWQFQPVKLIRYVTAFDFFLAACEIIFCFFIL 483

  Fly   384 WLQFTKAFFLKVWYDPRQLKTLWVQVDAMIVALSLVVGMIMSVRDNLVQKMIKSVEIAVVVDFLD 448
            :....:...::: :.....::.|..:|.:||.||:|..||...|.:..:.:::.:|     |...
  Rat   484 YYVVEEILEIRI-HRLNYFRSFWNCLDVVIVVLSVVAMMINIYRMSNAEGLLQFLE-----DQNS 542

  Fly   449 FREPAQLAYLE---DVVTGLAVALVTMRLWKVLQFSATF-QLFTKTIAMAWDALLCTFVITVIFI 509
            |.....:||.:   :.:..:.|.||.::|:|.:.|:.|. ||.|.....|.|....|.:..:||:
  Rat   543 FPNFEHVAYWQIQFNNIAAVMVFLVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFTIMFFIIFL 607

  Fly   510 IAIGIATVTINGNYTSNFRDFPKGIVTVTCFAFGYTNLVYPPDIFYGGEWLGILLYTIMGFVVKY 574
            ....:|.: :.|....:|..|.:.|.|......|..|..   :|......||.|.:|...|.:.:
  Rat   608 AYAQLAYL-VFGTQVDDFSTFQECIFTQFRIILGDINFA---EIEEANRVLGPLYFTTFVFFMFF 668

  Fly   575 MLINLIVSMMRDQMASVKADRDKKVRQRITFWQFLRVEYAHFINYIVKVFHCQKGYQR---KNRT 636
            :|:|:.::::.|..:.||:|..:         |...:|.:..|..     .|||...:   |..|
  Rat   669 ILLNMFLAIINDSYSEVKSDLAQ---------QKAEMELSDLIRK-----GCQKALVKLKLKRNT 719

  Fly   637 V---AQNIQR---KLNSNELKR-------RKTKISSIYSETIYVMPIDKDL---EQMKYRERIER 685
            |   ::::::   |||.:||::       ...:|.:|:  |.|....|::|   |..:.|:.:||
  Rat   720 VDAISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIF--TKYDQDGDQELTEREHQQMRDDLER 782

  Fly   686 TFTLAAILHTQMELMERLMFGDEEGNLP----------SLDQEDEQVPETEED 728
                           ||.....|..:||          |||..:|   |.:||
  Rat   783 ---------------EREDLDLEHSSLPRPMSSRSFPRSLDDSEE---EDDED 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	Polycystin_dom	167..363	CDD:466668	57/204 (28%)
		PKD_channel	364..591	CDD:462341	52/235 (22%)
Pkd2	NP_001178863.1	Polycystin_dom	267..461	CDD:466668	69/259 (27%)
		PKD_channel	462..685	CDD:462341	52/232 (22%)
		FRQ1	<732..772	CDD:444056	11/41 (27%)
		Fer4_24	832..866	CDD:436280