DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brv1 and pkd2

DIOPT Version :9

Sequence 1:	NP_649116.1	Gene:	brv1 / 40116	FlyBaseID:	FBgn0036874	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_001002310.1	Gene:	pkd2 / 432387	ZFINID:	ZDB-GENE-040827-4	Length:	904	Species:	Danio rerio

Alignment Length:	703	Identity:	155/703 - (22%)
Similarity:	285/703 - (40%)	Gaps:	148/703 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 RLRTLRSELMITERHRNERVNLK---YRLITEELWLTGKLFLVYFFMALAFFDELLYFNTEATEL 156
            ::|.|....::.|.:.|..:.||   ..:||..|:|.....:.|..::..     :|:.|:....
Zfish   132 KMRVLWDTRLLGESNSNREMYLKTVLREMITYILFLLTLCIITYGMVSTN-----MYYYTKVMSQ 191

  Fly   157 LF---QCNHGDAFGLLSVGDVPDIYFFVVSSLVLAFTDGKNTSGGAPW---------------IH 203
            ||   ..:.|:.....|:..:.|.:         .||:|...: |..|               |:
Zfish   192 LFLDTPLSSGEPTNFKSLSTMEDFW---------KFTEGPFLN-GMYWELWYNNKSLPENQSLIY 246

  Fly   204 AEGTRLLGVVRLRQLRTESNRLGLSLPVFTERDFSESWTLPYERVPYTDKYWPIY---------- 258
            .|.. ||||.||||||..                :||.::..:   ..|:.:..|
Zfish   247 YENL-LLGVPRLRQLRVR----------------NESCSVHED---LRDEVYDCYNVYSPANEDK 291

  Fly   259 TPWLPSVSVA---RDNLLMG-INHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANT 319
            .|:.|....|   :|...:| .::.|.:..| ...||...||.||.||...:..|....|||..|
Zfish   292 APFGPKNGTAWRFKDESSLGESSYWGQVSTY-GGGGYYQDLSRTREKSANQLQELKNNLWLDRGT 355

  Fly   320 TALFMDFSLYNADANTFTVCTLWVEKFPYQYPDGHTRIESHTF--VEQLREFTKF----GMLMV- 377
            .|:|:|||:||.:.|.|.:..|.||     :|.....:.|..|  |..||..:.:    ||..|
Zfish   356 RAVFLDFSIYNGNVNLFCIVRLLVE-----FPATGGAVPSWQFQTVRLLRYVSSWDYFVGMCEVS 415

  Fly   378 FVFVVTWLQFTKAFFLKVWYDPRQLKTLWVQVDAMIVALSLVVGMIMSVRDNLVQKMIKSVEIAV 442
            |...|.:....:|..::: :..|..|:||..:|.:||||| |..:||    |:.:....|..:..
Zfish   416 FCLFVLYYLVEEALEIRL-HRLRYFKSLWNCLDVLIVALS-VPAIIM----NICRTSAVSHRLHF 474

  Fly   443 VVD----FLDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFV 503
            :::    :.:|...|:|....:.:..:.|.|..::|:|.:.|:.|....:.|::.....|:...:
Zfish   475 LLENHSTYPNFEPLARLQVHFNNLAAIIVFLSWVKLFKFINFNKTMNQLSTTMSRCAKDLMGFAI 539

  Fly   504 ITVIFIIAIGIATVTINGNYTSNFRDFPKGIVT---VTCFAFGYTNLVYPPDIFYGGEWLGILLY 565
            :..|..:|.......:.|...::|..|...|.|   :....|.::.:.....:      ||.:.:
Zfish   540 MFFIVFLAYAQLAYLVFGTQVNDFSTFQACIFTQFRIILGDFDFSEIEEADSV------LGPIYF 598

  Fly   566 TIMGFVVKYMLINLIVSMMRDQMASVKADRDKKVRQRITFWQFLRVEYAHFINYIVKVFHCQKGY 630
            |...|.:..:|:|:.::::.|..:.||||..:: |..:.....::..|.   ..:||:    |..
Zfish   599 TTFVFFIFMILLNMFLAIINDTYSEVKADMAQQ-RSEMEITDLIKKSYN---RAMVKL----KLK 655

  Fly   631 QRKNRTVAQNIQR---KLNSNELKR-------RKTKISSIYSETIYVMPIDKDL---EQMKYRER 682
            :.....:..::|:   ||:.:||::       ...:|.:|:::  |.:..|::|   |..:.|:.
Zfish   656 KSSINDIPDSLQQAAGKLSFDELRQDLRGKGHSDAEIEAIFAK--YDLDGDQELTEHEHQQMRDD 718

  Fly   683 IERTFTLAAILHTQMELMERLMFGDEEGNLP--------SLDQEDEQVPETEE 727
            :|:               ||.....|..:||        |..|:|.:..:.|:
Zfish   719 LEK---------------EREDLDLEHSSLPRPASGRSFSRSQDDSEEDDDED 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	108/468 (23%)
pkd2	NP_001002310.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102
		PKD_channel	204..624	CDD:285288	108/467 (23%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:Q13563	578..580		0/1 (0%)
		EFh	<671..715	CDD:324233	10/45 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..770		12/64 (19%)
		Linker. /evidence=ECO:0000250\|UniProtKB:Q13563	740..759		4/17 (24%)
		Pkinase	<781..>856	CDD:330832
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810