Protein Alignment brv1 and Pkd2l1

DIOPT Version :10

• Sequence 1: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: NP_852087.2
• Gene: Pkd2l1 / 329064
• MGIID: 1352448
• Length: 760
• Species: Mus musculus
• Alignment Length: 736
• Identity: 157/736 - (21%)
• Similarity: 278/736 - (37%)
• Gaps: 140/736 - (19%)

  Fly    56 TPIKFTIMSLDAAFW--PAHQAPETPDENANVDTFMD-----------NLRLRLRTLRSEL---- 103
            :|....:.:|....|  ||:..|.:|:....:.|...           .:|.:.:|.|:.:
Mouse     6 SPKNQELQTLGNRAWDNPAYSDPPSPNRTLRICTVSSVALPETQPKKPEVRCQEKTQRTLVSSCC 70

  Fly   104 -------------MITERHRNER---VNLKYR-LITEELWLTGKLFLVYFFMALAFFDELLYFNT 151
                         .:||.....|   |....| |:...::|.....|.|...:.:.:    |:..
Mouse    71 LHICRSIRGLWGTTLTENTAENRELYVKTTLRELVVYIVFLVDICLLTYGMTSSSAY----YYTK 131

  Fly   152 EATELLFQCNHGDAFGLLSVGDVPDIYFFVVSSLV--LAFTDGKNTS----GGAPWIHAEGTRLL 210
            ..:||.............::..:.|.:.|....|:  |.:|...|..    |...:|:.|.. ||
Mouse   132 VMSELFLHTPSDSGVSFQTISSMSDFWDFAQGPLLDSLYWTKWYNNQSLGRGSHSFIYYENL-LL 195

  Fly   211 GVVRLRQLRTESNRLGLSLPVFTERDFSESWTLPYERVPYTDKYWPIYTPWLP-------SVSVA 268
            |..||||||..::      ......||.|.....|      |.|.|.....||       :.:..
Mouse   196 GAPRLRQLRVRND------SCVVHEDFREDILNCY------DVYSPDKEDQLPFGPQNGTAWTYH 248

  Fly   269 RDNLLMGINHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADA 333
            ..|.|.|.:|.|.:.:| ...||.:.|..:|..|.:.:..|.:..|||..|..:|:|||:|||:.
Mouse   249 SQNELGGSSHWGRLTSY-SGGGYYLDLPGSRQASAEALQGLQEGLWLDRGTRVVFIDFSVYNANI 312

  Fly   334 NTFTVCTLWVEKFPYQYPDGHT----RIESHTFVEQLREFTKFGMLMVFVFVVTWLQFTKAFFLK 394
            |.|.:..|.|| ||   ..|.|    :|.:...:..:..:..|.:....||.|....:.....|:
Mouse   313 NLFCILRLVVE-FP---ATGGTIPSWQIRTVKLIRYVNNWDFFIVGCEVVFCVFIFYYVVEEILE 373

  Fly   395 V-WYDPRQLKTLWVQVDAMIVALSLV-VGM----IMSVRDNLVQKMIKSVEIAVVVDFLDFREPA 453
            : .:..|.|.::|..:|.:::.||:| ||.    .:.| :.|:.|:::..:.....:||.|   .
Mouse   374 IHLHRLRYLSSVWNILDLVVILLSIVAVGFHIFRTLEV-NRLMGKLLQQPDTYADFEFLAF---W 434

  Fly   454 QLAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVITVIFIIAIGIATVT 518
            |..|.......|..|.:  :::|.:.|:.|....:.|:|.....:|...::..|...|.......
Mouse   435 QTQYNNMNAVNLFFAWI--KIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYL 497

  Fly   519 INGNYTSNFRDFPKGIVTVTCFAFGYTNLVYPPDIFY-----GGEWLGILLYTIMGFVVKYMLIN 578
            :.|....||..|.|.|.|......|        |..|     ....||.:.:....|.|.::|:|
Mouse   498 LFGTQVENFSTFVKCIFTQFRIILG--------DFDYNAIDNANRILGPVYFVTYVFFVFFVLLN 554

  Fly   579 LIVSMMRDQMASVKADRDKKVRQRITFWQFLRVEYAHFINYIVKVFHCQKGYQRKNRTVAQNIQR 643
            :.::::.|..:.||.:...: :.::....||:..|                    |:|:.:
Mouse   555 MFLAIINDTYSEVKEELAGQ-KDQLQLSDFLKQSY--------------------NKTLLR---- 594

  Fly   644 KLNSNELKRRKTKISSIYSETIYVMPIDKDLEQMKYRERIER-TFTLAAILHTQMELMERLMFGD 707
                  |:.||.::|.          :.|.|:..:...:.|. |.||..:.|.:.|:.......|
Mouse   595 ------LRLRKERVSD----------VQKVLKGGEPEIQFEDFTSTLRELGHEEHEITAAFTRFD 643

  Fly   708 EEGNLPSLDQEDEQVPETEED 728
            ::|:....::|.||:.:..|:
Mouse   644 QDGDHILDEEEQEQMRQGLEE 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	Polycystin_dom	167..363	CDD:466668	60/212 (28%)
		PKD_channel	364..591	CDD:462341	49/237 (21%)
Pkd2l1	NP_852087.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		6/23 (26%)
		Polycystin_dom	147..342	CDD:466668	60/212 (28%)
		PKD_channel	343..567	CDD:462341	49/237 (21%)
		EFh	616..654	CDD:415501	8/37 (22%)
		Fer4_24	699..732	CDD:436280
		Required for homooligomerization. /evidence=ECO:0000250	701..760