DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv1 and Pkd2l1

DIOPT Version :9

Sequence 1:	NP_649116.1	Gene:	brv1 / 40116	FlyBaseID:	FBgn0036874	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_038964804.1	Gene:	Pkd2l1 / 293937	RGDID:	1306261	Length:	763	Species:	Rattus norvegicus

Alignment Length:	730	Identity:	160/730 - (21%)
Similarity:	281/730 - (38%)	Gaps:	154/730 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 IMSLDAAFW--PAHQAPETPDENANVDTFMD-----------NLRLRLRTLRSE-----LMI--- 105
            :.:|.:..|  ||:.:|.:|:....:.|...           .:|.:.:|.|..     |:|
  Rat    12 LQTLGSRVWDNPAYSSPPSPNGTPRICTVSSVALPETQPKKPEVRRQEKTPRVPVSGCCLLICRG 76

  Fly   106 ------------TERHRNERVNLKYR-LITEELWLTGKLFLVYFFMALAFFDELLYFNTEATELL 157
                        |..:|...|....| |:...::|.....|.|...:.:.:    |:....:||.
  Rat    77 IRGLWGTTLTENTAENRELYVKTTLRELVVYIVFLVDVCLLTYGMTSSSAY----YYTKVMSELF 137

  Fly   158 FQCNHGDAFGLLSVGDVPDIYFFVVSSLV--LAFTDGKNT----SGGAPWIHAEGTRLLGVVRLR 216
            .......|....::..:.|.:.|....|:  |.:|...|.    |....:|:.|.. ||||.|||
  Rat   138 LHTPSESAVSFQTISSMSDFWDFAQGPLLDSLYWTKWYNNQSLGSSSHSFIYYENL-LLGVPRLR 201

  Fly   217 QLRTESNRLGLSLPVFTERDFSESWTLPYERVPYTDK-----YWPIY-TPWLPSVSVARDNLLMG 275
            |||..::      ......||.|.....|: |...||     :.|:. |.|    :....|.|.|
  Rat   202 QLRVRND------SCVVHEDFREDILNCYD-VYSPDKEDQLPFGPLNGTAW----TYHSQNELGG 255

  Fly   276 INHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFTVCT 340
            .:|.|.:.:| ...||.:.|..:|..|.:.:..|.:..|||..|..:|:|||:|||:.|.|.:..
  Rat   256 SSHWGRLTSY-SGGGYYLDLPGSRQASAEALQGLQEGLWLDRGTRVVFIDFSVYNANINLFCILR 319

  Fly   341 LWVEKFPY---QYPDGHTRIESHTFVEQLR-----EFTKFGMLMVFVFVVTWLQFTKAFFLKVWY 397
            |.|| ||.   ..|....|.     |:.:|     :|...|..::|...:.:....:...::| :
  Rat   320 LVVE-FPATGGAIPSWQIRT-----VKLIRYVNNWDFFIVGCEVIFCIFIFYYVVEEILEIRV-H 377

  Fly   398 DPRQLKTLWVQVDAMIVALSLV-VGM----IMSVRDNLVQKMIKSVEIAVVVDFLDFREPAQLAY 457
            ..|.|.::|..:|.:::.||:| ||.    .:.| :.|:.::::..:.....:||.|   .|..|
  Rat   378 RFRYLSSVWNILDLVVILLSIVAVGFHVFRTLEV-NRLMGELLQQPDTYPDFEFLAF---WQTQY 438

  Fly   458 LEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVITVIFIIAIGIATVTINGN 522
            .......|..|.:  :::|.:.|:.|....:.|:|.....:|...::..|...|.......:.|.
  Rat   439 NNMNAVNLFFAWI--KIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLFGT 501

  Fly   523 YTSNFRDFPKGIVTVTCFAFGYTNLVYPPDIFY-----GGEWLGILLYTIMGFVVKYMLINLIVS 582
            ...:|..|.|.|.|......|        |..|     ....||.:.:....|.|.::|:|:.::
  Rat   502 QVESFSTFVKCIFTQFRIILG--------DFDYNAIDNANRILGPVYFITYVFFVFFVLLNMFLA 558

  Fly   583 MMRDQMASVKADRDKKVRQRITFWQFLRVEYAHFINYIVKVFHCQKGYQRKNRTVAQNIQRKLNS 647
            ::.|..:.||.:...: |.::.....|:..|                        ::.:||
  Rat   559 IINDTYSEVKEELAGQ-RDQLQLSDLLKQSY------------------------SKTLQR---- 594

  Fly   648 NELKRRKTKISSIYSETIYVMPIDKDLEQMKYRERIER-TFTLAAILHTQMELME------RLMF 705
              |:.||.::|.          :.|.|:..:...:.|. |.||..:.|.:.|:.|      |.
  Rat   595 --LRLRKERVSD----------VQKVLKGGEPEIQFEDFTNTLRELGHAEREISEVSAAFTRF-- 645

  Fly   706 GDEEGNLPSLDQEDE 720
             |.:|: ..||:||:
  Rat   646 -DRDGD-HILDEEDQ 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	110/455 (24%)
Pkd2l1	XP_038964804.1	PKD_channel	147..567	CDD:400395	109/453 (24%)
		Smc	<557..>743	CDD:224117	28/147 (19%)
		Fer4_24	702..735	CDD:407943
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46093
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820