Protein Alignment brv1 and Pkd2l2

DIOPT Version :9

• Sequence 1: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: NP_001099626.1
• Gene: Pkd2l2 / 291683
• RGDID: 1310272
• Length: 621
• Species: Rattus norvegicus
• Alignment Length: 691
• Identity: 143/691 - (20%)
• Similarity: 259/691 - (37%)
• Gaps: 160/691 - (23%)

  Fly   106 TERHRNERVNLKYRLITEELWLTGKLFLVYFFM----ALAF---FDELLYFNTEATELLFQCNHG 163
            |.:|     :|.||...|......:|.|.:.|:    .|.|   ...:.|.|...:.|....:..
  Rat    12 TSKH-----DLHYRREAEVNTTLEELLLYFIFLINLCILTFGTVNPHMYYLNKVMSSLFVDTSLP 71

  Fly   164 D--AFGLLSVGDVPDIYFFVVSSLVLA-FTDG----------KNTSGGAPWIHAEGTRLLGVVRL 215
            |  .....|:..:.:.:.|:...||.. :.|.          ||:|    .|:.|.. ||||.|:
  Rat    72 DDERSSFRSIRSITEFWKFMEGPLVEGLYWDSWYGNTQLDSVKNSS----LIYYENI-LLGVPRV 131

  Fly   216 RQLRTESNRLGLSLPVF-------------TERDFSE-------SW--TLPYERVPYTDKYWPIY 258
            ||||..::...: .|.|             ...|||:       .|  :.|....|:   :|..
  Rat   132 RQLRVRNSTCQV-YPAFQSLASDCYNKYTAENEDFSDFGLKHDPEWRHSAPSSTAPW---HWGF- 191

  Fly   259 TPWLPSVSVARDNLLMGINHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALF 323
                  |.|.||.                  ||.|.||.::.::...:..|.:.||:...|.|:|
  Rat   192 ------VGVYRDG------------------GYMVTLSKSKSETKAKLADLRQNNWIGRGTRAVF 232

  Fly   324 MDFSLYNADANTFTVCTLWVEKFP--------YQYPDGHTRIESHTFVEQLREFTKFGMLMVFVF 380
            :|||||||:.|.|.:..|..| ||        :|:    ..::...:|.....|.....::..:|
  Rat   233 IDFSLYNANVNLFCIIRLLAE-FPATGGILTSWQF----YSVKLIRYVSYYDHFIASCEIIFCIF 292

  Fly   381 VVTWL--------QFTKAFFLKVWYDPRQLKTLWVQVDAMIVALSLVVGMIMSVRDN---LVQKM 434
            ::.::        :|..|:|..||.        |::: .::|...|.|.........   |:.::
  Rat   293 LLVFITQELRKLNEFKSAYFRSVWN--------WIEL-LLLVLCFLAVSFYAYCNVQCFLLLGQL 348

  Fly   435 IKSVEIAVVVDFLDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALL 499
            ::|.|     .:.||...|......:.:..:.:....::::|.:.|:.|....:.|::.....::
  Rat   349 LRSTE-----SYPDFYFLAYWHIYYNNIIAITIFFAWIKIFKFISFNETMSQLSSTLSRCMKDIV 408

  Fly   500 CTFVITVIFIIAIGIATVTINGNYTSNFRDFPKGIVTVTCFAFGYTNLVYPPDIFYG---GEW-L 560
            ...::..|...|.......:.|:...:|..|...|       |....:|.....|.|   ..| |
  Rat   409 GFAIMFFIIFFAYAQLAFLVFGSQVDDFSTFQNSI-------FAQFRIVLGDFNFAGIQQANWIL 466

  Fly   561 GILLYTIMGFVVKYMLINLIVSMMRDQMASVKADRDKKVRQRITFWQFLRVEYAHFINYIVKVFH 625
            |.:.:....|.|.::|:|:.::::.|..:.|||  |..:.:|..|          .:..|:|
  Rat   467 GPIYFITFIFFVFFVLLNMFLAIINDTYSEVKA--DYSIGRRPDF----------ELGSIIK--- 516

  Fly   626 CQKGYQRKNRTVAQNIQ-RKLNSNELKRRKTKI--SSIYSETIYVMPIDKDLEQMKYRERIERTF 687
                  :....:.:.:: ||..:||.|:.||.:  :....|......|.:..:..:::||:|:.:
  Rat   517 ------KSCFNILEKLRLRKAQNNEDKKMKTSVDLAQARKEGFDESEIQEARQMKRWKERLEKKY 575

  Fly   688 TLAAILH-----TQMELMERLMFGDE-EGNLPSLDQEDEQV 722
            ....|..     ||.|..|..::..| |..|..|..:..||
  Rat   576 YSTEIQDDYQPVTQQEFRELFLYAVELEKELHYLSLKLNQV 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	97/481 (20%)
Pkd2l2	NP_001099626.1	PKD_channel	76..497	CDD:285288	97/480 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810