DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brv1 and Pkd1l1

DIOPT Version :9

Sequence 1:	NP_649116.1	Gene:	brv1 / 40116	FlyBaseID:	FBgn0036874	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_038948500.1	Gene:	Pkd1l1 / 289796	RGDID:	1564724	Length:	2586	Species:	Rattus norvegicus

Alignment Length:	419	Identity:	91/419 - (21%)
Similarity:	156/419 - (37%)	Gaps:	103/419 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 HQAPETPDENANVDTFMDNLRLRLRTLR--------SELMITERHRNERVNLKYRLITEELWLTG 129
            |.||..|...|        .|.|.|.||        ...::.||.|.||:   .:....::.:..
  Rat  1974 HGAPLPPQVLA--------ARQRERHLRWAQTPSGPKFRVMRERLRRERL---MQAALRDVTMHS 2027

  Fly   130 KLFLVYFFMALAFFDELLYFNTEATELLFQCNHGDAFGLLSVGDVPDIYFFVVSSLVLAFTDGKN 194
            .:.|:..|:|...|....|...:|....|..|...:.|.||  ...|.:.:.:|:|:    ||.:
  Rat  2028 VMLLLLLFIAYGRFCPGEYSLNQAIRRAFTRNAHHSLGDLS--STEDWWDWTLSTLL----DGLH 2086

  Fly   195 TS-------GGAPWIHAEGTRLLGVVRLRQLRTESNRLGLSLPVFTERDFSESWTLPYERVPYTD 252
            ..       |..|........|:|...::||:..:....::...|:|               ..:
  Rat  2087 PERMPATAWGSQPGALGGQCHLIGPSVIKQLKVSAGTACVAPKPFSE---------------LVE 2136

  Fly   253 KYWPIYTPW--LPSVSVARDNLLMGINHVGHMFNYPESKG-----YKVLLSDTRHKSLKIIDYLM 310
            ...|:::..  |.:.:|..|:              |::.|     |...|..|||::...:..|.
  Rat  2137 DVLPMHSHALDLENRNVTPDD--------------PKTCGVKKESYTHSLGRTRHEAHAALTALR 2187

  Fly   311 KKNWLDANTTALFMDFSLYNADANTFTVCTLWVEKFPYQYPDGHTR-IESHTFVEQLREFTKFG- 373
            ...|:|.:|.|:.:.|:|||.....||..||..|..       .|| :.|.:.:|....|.:..
  Rat  2188 ASRWIDHSTRAVSVHFTLYNPPTRLFTSVTLGAEFL-------STRGLVSSSLIESFSIFYRDSA 2245

  Fly   374 -----MLMVFVFVV---------TWLQFTKAFFLKVWYDPRQLKTLWVQVDAMIVALSLVV--GM 422
                 ||...:|:|         .|...||. .|..|..|||    |:::..:.|||:...  |.
  Rat  2246 LQCLLMLSELLFLVLNMIHLCFQLWEMATKG-ILSYWRKPRQ----WLELSMVGVALAYCAASGH 2305

  Fly   423 IMSVRDNLVQKMIKS-----VEIAVVVDF 446
            :.::.:|:..:..|.     |:|:::|.:
  Rat  2306 LTTLAENITDQFHKGLYQRFVDISLMVSW 2334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	68/319 (21%)
Pkd1l1	XP_038948500.1	PCC	<242..725	CDD:188093
		GPS	1398..1436	CDD:413374
		PLAT_polycystin	1504..1622	CDD:238850
		PKD_channel	2063..2389	CDD:400395	68/319 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920