Protein Alignment brv1 and PKD2L2

DIOPT Version :9

• Sequence 1: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: NP_001287850.1
• Gene: PKD2L2 / 27039
• HGNCID: 9012
• Length: 624
• Species: Homo sapiens
• Alignment Length: 659
• Identity: 141/659 - (21%)
• Similarity: 257/659 - (38%)
• Gaps: 131/659 - (19%)

  Fly   109 HRN--ERVNLKYRLITEELWLTGKL--FLVYF-------FMALAFFDELLYFNTEATELLF---Q 159
            ||.  .:..|.||   :|:.:|..|  .|:||       .:.....:..:|:..:....||   .
Human     8 HRGGASKHKLHYR---KEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTS 69

  Fly   160 CNHGDAFGLLSVGDVPDIYFFVVSSLVLA-FTDG----------KNTSGGAPWIHAEGTRLLGVV 213
            ....:.....|:..:.|.:.|:...|:.. :.|.          ||:|.    |:.|.. ||||.
Human    70 VPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSR----IYYENI-LLGVP 129

  Fly   214 RLRQLRTESNRLGLSLPVFTERDFSESWTLPYERV-PYTDKY-------WPIYTPWLPSVSVARD 270
            |:|||:..:|         |.:.:|...:|..|.. .||...       ..|.|.|..|.|....
Human   130 RVRQLKVRNN---------TCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNS 185

  Fly   271 NLLMGINHV----GHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNA 331
            ....|...|    |::|...:||      |:|::   |.|| |...:|:...|..:|:|||||||
Human   186 PWHWGFLGVYRNGGYIFTLSKSK------SETKN---KFID-LRLNSWITRGTRVIFIDFSLYNA 240

  Fly   332 DANTFTVCTLWVEKFPYQYPDGHTRIESHTF--VEQLREFTKFGMLM--------VFVFVVTW-- 384
            :.|.|.:..|..|     :|.....:.|..|  |:.||..:.:...:        :|:||.|.
Human   241 NVNLFCIIRLVAE-----FPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE 300

  Fly   385 ----LQFTKAFFLKVWYDPRQLKTLWVQVDAMIVALSLVVGMIMSVRDN-----LVQKMIKSVEI 440
                .:|..|:|..:|.        |::   :::.|...|.:..:...|     |:.:::||.|
Human   301 VKKIKEFKSAYFKSIWN--------WLE---LLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTE- 353

  Fly   441 AVVVDFLDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVIT 505
                .:.||...|......:.:..:.:....::::|.:.|:.|....:.|::.....::...::.
Human   354 ----KYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMF 414

  Fly   506 VIFIIAIGIATVTINGNYTSNFRDFPKGIVTVTCFAFGYTNLVYPPDIFYGGEWLGILLYTIMGF 570
            .|...|.......:.|:...:|..|...|........|..|..   .|......||.:.:....|
Human   415 FIIFFAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFA---GIQQANPILGPIYFITFIF 476

  Fly   571 VVKYMLINLIVSMMRDQMASVKADRDKKVRQRITF--WQFLRVEYAHFINYIVKVFHCQKGYQRK 633
            .|.::|:|:.::::.|..:.|||  |..:.:|:.|  .:.::..|.:.:... ::...||...:|
Human   477 FVFFVLLNMFLAIINDTYSEVKA--DYSIGRRLDFELGKMIKQSYKNVLEKF-RLKKAQKDEDKK 538

  Fly   634 NR---TVAQNIQRK-------LNSNELKRRKTKISSIYSETIYVMPIDKDLE---QMKYRERIER 685
            .:   .:|:..:|:       .|:.::|:.|.::...|    |.|.|..|.:   |.::||....
Human   539 TKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKY----YSMEIQDDYQPVTQEEFRELFLY 599

  Fly   686 TFTLAAILH 694
            ...|...||
Human   600 AVELEKELH 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	101/469 (22%)
PKD2L2	NP_001287850.1	PKD_channel	76..497	CDD:332708	101/468 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5820
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.760