DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv1 and Pkd1l3

DIOPT Version :9

Sequence 1:	NP_649116.1	Gene:	brv1 / 40116	FlyBaseID:	FBgn0036874	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_017168310.1	Gene:	Pkd1l3 / 244646	MGIID:	2664670	Length:	2206	Species:	Mus musculus

Alignment Length:	652	Identity:	141/652 - (21%)
Similarity:	234/652 - (35%)	Gaps:	175/652 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FYLTLIIIAI--CVACIWMFSGFRHEYGKFNMILVAFLAVTLLQ-ILIFTPIKFTIMSLDAAFWP 71
            |::||..:.:  ..|..|:.|                :.:::|| |.|..|||...::|..:...
Mouse  1578 FFITLYSLELDKDQATSWVIS----------------MMLSVLQDIFISQPIKVIFLTLLFSLMA 1626

  Fly    72 AH------------------------QAPETPDENANVDT--FMDNLRLRLRTLRSELMITERHR 110
            .|                        .||...|:|..:.|  .|:||....|         :..:
Mouse  1627 NHMPWLNKDKEQHARRIVALWAKCPWSAPGLRDKNNPIYTAPAMNNLAKPTR---------KAWK 1682

  Fly   111 NERVNLKYRLITEELWLTGKLFLVY-------FFMALAFFDELLY----------FNTEATELLF 158
            .:...|....:.:.|:||..:..||       ||:..|.:....:          |...|...|.
Mouse  1683 KQLSKLTGGTLVQILFLTLLMTTVYSAKDSSRFFLHRAIWKRFSHRFSEIKTVEDFYPWANGTLL 1747

  Fly   159 QCNHGDAFGLLSVGDVPDIYFFVVSSLVLAFTDGKNTSGGAPWIHAEGTRLLGVVRLRQLRTES- 222
            ...:||..|.:                    |||.:.             |||.|.:||.|..:
Mouse  1748 PNLYGDYRGFI--------------------TDGNSF-------------LLGNVLIRQTRIPND 1779

  Fly   223 -------NRLGLSLPVFTE--RDFSESWTLPYERVPYTDKYWPIYTPWLPSVSVARDNLLMGINH 278
                   ::...|.|...|  .::...|..|...:...|..|          .......|.|...
Mouse  1780 IFFPGSLHKQMKSPPQHQEDRENYGAGWVPPDTNITKVDSIW----------HYQNQESLGGYPI 1834

  Fly   279 VGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFTVCTLWV 343
            .|.:..| ...||.|.|......:.:::.:|.::.|||..|.|||::|:::||:.|.....||.:
Mouse  1835 QGELATY-SGGGYVVRLGRNHSAATRVLQHLEQRRWLDHCTKALFVEFTVFNANVNLLCAVTLIL 1898

  Fly   344 EK------FPYQYPDGHTRIESHTFVEQLREFTKFGMLMVFVFVVTWLQFTKAFFLKVWYDPRQL 402
            |.      ......|..|.::|..     |.|......:|:..:|.:..|.:...||     ||.
Mouse  1899 ESSGVGTFLTSLQLDSLTSLQSSE-----RGFAWIVSQVVYYLLVCYYAFIQGCRLK-----RQR 1953

  Fly   403 KTLWVQ----VDAMIVALSL-VVGMIMSVRDNLVQKMIKSVEIAVVVD---FLDFREPAQLAYLE 459
            ...:.:    :|..||.:|. ::|:.|.....|.:||.:     ...|   |:.|.|..::....
Mouse  1954 LAFFTRKRNLLDTSIVLISFSILGLSMQSLSLLHKKMQQ-----YHCDRDRFISFYEALRVNSAV 2013

  Fly   460 DVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVITVIFIIAIGIATVTINGNYT 524
            ..:.|..:...|:|:|.:|:..|..|:..||::.|||.:|...:|.|:.:.:..:....:.|...
Mouse  2014 THLRGFLLLFATVRVWDLLRHHAQLQVINKTLSKAWDEVLGFILIIVVLLSSYAMTFNLLFGWSI 2078

  Fly   525 SNFRDFPKGIVTVTCFAFGYTN-----LVYPPDIFYGGEWLGILL----YTIMGFVVKYMLINLI 580
            |:::.|.:.||||.....|.:.     .:||        .||.||    ..:||.|:    |||.
Mouse  2079 SDYQSFFRSIVTVVGLLMGTSKHKEVIALYP--------ILGSLLVLSSIILMGLVI----INLF 2131

  Fly   581 VS 582
            ||
Mouse  2132 VS 2133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	103/451 (23%)
Pkd1l3	XP_017168310.1	CLECT	37..142	CDD:153057
		Atrophin-1	<137..>472	CDD:367360
		Herpes_BLLF1	<325..652	CDD:282904
		GPS	1041..1079	CDD:366827
		PLAT_polycystin	1151..1269	CDD:238850
		PKD_channel	1729..2139	CDD:369653	108/476 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910