Protein Alignment brv1 and Pkd2

DIOPT Version :10

• Sequence 1: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: NP_032887.3
• Gene: Pkd2 / 18764
• MGIID: 1099818
• Length: 966
• Species: Mus musculus
• Alignment Length: 688
• Identity: 163/688 - (23%)
• Similarity: 284/688 - (41%)
• Gaps: 120/688 - (17%)

  Fly    96 LRTLRSELMITERHRNERVNLK---YRLITEELWLTGKLFLVYFFMALAFFDELLYFNTEATELL 157
            ||.|....::.|.:.|....||   ..|:|...:|.....|.|..|:     ..:|:.|.....|
Mouse   195 LRGLWGTRLMEESNANREKYLKSVLRELVTYLFFLVVLCILTYGMMS-----SNVYYYTRTLSQL 254

  Fly   158 F---QCNHGDAFGLLSVGDVPDIYFFVVSSLV-----LAFTDGKNTSGGAPWIHAEGTRLLGVVR 214
            |   ..:..:.....::..:.|.:.|...|.:     .|.|.....:....:|..|.. ||||.|
Mouse   255 FIDTPVSKTEKTNFKTLSSMEDFWKFTEGSFLDGLYWKAQTSNHTQADNRSFIFYENL-LLGVPR 318

  Fly   215 LRQLRTESNRLGLSLPVFTERDFSESWTL----PYERVPYTDKYWPIYTPWLPSVSVARDNLLMG 275
            |||||..:.  ..|:|.....:..|.:.:    ..:|.|:..:..   |.|:    ...:..|.|
Mouse   319 LRQLRVRNG--SCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNG---TAWM----YTSEKELNG 374

  Fly   276 INHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFTVCT 340
            .:|.|.:.:| ...||.:.||.||.::...:..|.:..|||..|.|.|:|||:|||:.|.|.|..
Mouse   375 SSHWGIIASY-SGAGYYLDLSRTREETAAQLAGLRRNFWLDRGTRAAFIDFSVYNANINLFCVVR 438

  Fly   341 LWVEKFPYQYPDGHTRIESHTF--VEQLREFTKFGMLM-----VFVFVVTWLQFTKAFFLKVWYD 398
            |..|     :|.....:.|..|  |:.:|..|.|...:     :|.|.:.:....:...::: :.
Mouse   439 LLAE-----FPATGGVVPSWQFQPVKLIRYVTAFDFFLAACEIIFCFFIIYYVVEEILEIRI-HR 497

  Fly   399 PRQLKTLWVQVDAMIVALSLVVGMIMSVRDNLVQKMIKSVEIAVVVDFLDFREPAQLAYLE---D 460
            ....::.|..:|.:||.||:|..:|...|.:..:.:::.:|     |...|.....:||.:   :
Mouse   498 LSYFRSFWNCLDVVIVVLSVVAMVINIYRMSNAEGLLQFLE-----DQNSFPNFEHVAYWQIQFN 557

  Fly   461 VVTGLAVALVTMRLWKVLQFSATF-QLFTKTIAMAWDALLCTFVITVIFIIAIGIATVTINGNYT 524
            .::.:.|.||.::|:|.:.|:.|. ||.|.....|.|....|.:.::||:....:|.: :.|...
Mouse   558 NISAVMVFLVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFTIMFSIIFLAYAQLAYL-VFGTQV 621

  Fly   525 SNFRDFPKGIVTVTCFAFGYTNLVYPPDIFYGGEWLGILLYTIMGFVVKYMLINLIVSMMRDQMA 589
            .:|..|.:.|.|......|..|..   :|......||.|.:|...|.:.::|:|:.::::.|..:
Mouse   622 DDFSTFQECIFTQFRIILGDINFA---EIEEANRVLGPLYFTTFVFFMFFILLNMFLAIINDSYS 683

  Fly   590 SVKADRDKKVRQRITFWQFLRVEYAHFINYIVKVFHCQKGYQR---KNRTV---AQNIQR---KL 645
            .||:|..:         |...:|.:..|..     .|||...:   |..||   ::::::   ||
Mouse   684 EVKSDLAQ---------QKAEMELSDLIRK-----GCQKALVKLKLKRNTVDAISESLRQGGGKL 734

  Fly   646 NSNELKR-------RKTKISSIYSETIYVMPIDKDL---EQMKYRERIERTFTLAAILHTQMELM 700
            |.:||::       ...:|.:|:  |.|....|::|   |..:.|:.:|:
Mouse   735 NFDELRQDLKGKGHTDAEIEAIF--TKYDQDGDQELTEREHQQMRDDLEK--------------- 782

  Fly   701 ERLMFGDEEGNLP----------SLDQEDEQVPETEED 728
            ||.....|..:||          |||..:|   |.:||
Mouse   783 EREDLDLEHSSLPRPMSSRSFPRSLDDSEE---EDDED 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	Polycystin_dom	167..363	CDD:466668	56/206 (27%)
		PKD_channel	364..591	CDD:462341	51/235 (22%)
Pkd2	NP_032887.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..106
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..179
		Polycystin_dom	267..461	CDD:466668	57/209 (27%)
		PKD_channel	462..685	CDD:462341	51/232 (22%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q13563	639..641		0/1 (0%)
		FRQ1	<732..772	CDD:444056	11/41 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	764..828		17/72 (24%)
		Linker. /evidence=ECO:0000250|UniProtKB:Q13563	801..820		7/20 (35%)
		Important for interaction with PACS1 and PACS2. /evidence=ECO:0000250|UniProtKB:Q13563	808..819		5/13 (38%)
		Fer4_24	832..866	CDD:436280
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	914..966