DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv1 and Pkd2

DIOPT Version :9

Sequence 1:	NP_649116.1	Gene:	brv1 / 40116	FlyBaseID:	FBgn0036874	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_032887.3	Gene:	Pkd2 / 18764	MGIID:	1099818	Length:	966	Species:	Mus musculus

Alignment Length:	688	Identity:	163/688 - (23%)
Similarity:	284/688 - (41%)	Gaps:	120/688 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 LRTLRSELMITERHRNERVNLK---YRLITEELWLTGKLFLVYFFMALAFFDELLYFNTEATELL 157
            ||.|....::.|.:.|....||   ..|:|...:|.....|.|..|:     ..:|:.|.....|
Mouse   195 LRGLWGTRLMEESNANREKYLKSVLRELVTYLFFLVVLCILTYGMMS-----SNVYYYTRTLSQL 254

  Fly   158 F---QCNHGDAFGLLSVGDVPDIYFFVVSSLV-----LAFTDGKNTSGGAPWIHAEGTRLLGVVR 214
            |   ..:..:.....::..:.|.:.|...|.:     .|.|.....:....:|..|.. ||||.|
Mouse   255 FIDTPVSKTEKTNFKTLSSMEDFWKFTEGSFLDGLYWKAQTSNHTQADNRSFIFYENL-LLGVPR 318

  Fly   215 LRQLRTESNRLGLSLPVFTERDFSESWTL----PYERVPYTDKYWPIYTPWLPSVSVARDNLLMG 275
            |||||..:.  ..|:|.....:..|.:.:    ..:|.|:..:..   |.|:    ...:..|.|
Mouse   319 LRQLRVRNG--SCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNG---TAWM----YTSEKELNG 374

  Fly   276 INHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFTVCT 340
            .:|.|.:.:| ...||.:.||.||.::...:..|.:..|||..|.|.|:|||:|||:.|.|.|..
Mouse   375 SSHWGIIASY-SGAGYYLDLSRTREETAAQLAGLRRNFWLDRGTRAAFIDFSVYNANINLFCVVR 438

  Fly   341 LWVEKFPYQYPDGHTRIESHTF--VEQLREFTKFGMLM-----VFVFVVTWLQFTKAFFLKVWYD 398
            |..|     :|.....:.|..|  |:.:|..|.|...:     :|.|.:.:....:...::: :.
Mouse   439 LLAE-----FPATGGVVPSWQFQPVKLIRYVTAFDFFLAACEIIFCFFIIYYVVEEILEIRI-HR 497

  Fly   399 PRQLKTLWVQVDAMIVALSLVVGMIMSVRDNLVQKMIKSVEIAVVVDFLDFREPAQLAYLE---D 460
            ....::.|..:|.:||.||:|..:|...|.:..:.:::.:|     |...|.....:||.:   :
Mouse   498 LSYFRSFWNCLDVVIVVLSVVAMVINIYRMSNAEGLLQFLE-----DQNSFPNFEHVAYWQIQFN 557

  Fly   461 VVTGLAVALVTMRLWKVLQFSATF-QLFTKTIAMAWDALLCTFVITVIFIIAIGIATVTINGNYT 524
            .::.:.|.||.::|:|.:.|:.|. ||.|.....|.|....|.:.::||:....:|.: :.|...
Mouse   558 NISAVMVFLVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFTIMFSIIFLAYAQLAYL-VFGTQV 621

  Fly   525 SNFRDFPKGIVTVTCFAFGYTNLVYPPDIFYGGEWLGILLYTIMGFVVKYMLINLIVSMMRDQMA 589
            .:|..|.:.|.|......|..|..   :|......||.|.:|...|.:.::|:|:.::::.|..:
Mouse   622 DDFSTFQECIFTQFRIILGDINFA---EIEEANRVLGPLYFTTFVFFMFFILLNMFLAIINDSYS 683

  Fly   590 SVKADRDKKVRQRITFWQFLRVEYAHFINYIVKVFHCQKGYQR---KNRTV---AQNIQR---KL 645
            .||:|..:         |...:|.:..|..     .|||...:   |..||   ::::::   ||
Mouse   684 EVKSDLAQ---------QKAEMELSDLIRK-----GCQKALVKLKLKRNTVDAISESLRQGGGKL 734

  Fly   646 NSNELKR-------RKTKISSIYSETIYVMPIDKDL---EQMKYRERIERTFTLAAILHTQMELM 700
            |.:||::       ...:|.:|:  |.|....|::|   |..:.|:.:|:
Mouse   735 NFDELRQDLKGKGHTDAEIEAIF--TKYDQDGDQELTEREHQQMRDDLEK--------------- 782

  Fly   701 ERLMFGDEEGNLP----------SLDQEDEQVPETEED 728
            ||.....|..:||          |||..:|   |.:||
Mouse   783 EREDLDLEHSSLPRPMSSRSFPRSLDDSEE---EDDED 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	108/445 (24%)
Pkd2	NP_032887.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..179
		PKD_channel	265..685	CDD:285288	108/445 (24%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:Q13563	639..641		0/1 (0%)
		EFh	730..776	CDD:298682	12/47 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..828		17/72 (24%)
		Linker. /evidence=ECO:0000250\|UniProtKB:Q13563	801..820		7/20 (35%)
		Important for interaction with PACS1 and PACS2. /evidence=ECO:0000250\|UniProtKB:Q13563	808..819		5/13 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	914..966
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810