Protein Alignment brv1 and pkd-2

DIOPT Version :9

• Sequence 1: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: NP_502838.3
• Gene: pkd-2 / 178424
• WormBaseID: WBGene00004035
• Length: 716
• Species: Caenorhabditis elegans
• Alignment Length: 714
• Identity: 142/714 - (19%)
• Similarity: 265/714 - (37%)
• Gaps: 179/714 - (25%)

  Fly   101 SELMITERHRNERVNLKYRLITEELWLTG--KLFL-VYFFMALAFFDELLYFNTEATELLFQCNH 162
            |:.::...|  |:.:.|.:|........|  .:|| |..::|.|......|:.::....||..:.
 Worm    52 SQALLASGH--EKSDGKIKLTARSFMEVGGYAVFLIVLVYVAFAQNSIQSYYYSKVMSDLFVAST 114

  Fly   163 G----DAFGLLSVGD----------VPDIYFFVVSSLVLAFTDGKNTSGGAPWIHAEGTRLLGVV 213
            |    .|||..:..|          :|.||          :|:..|::.....|:.| .||||..
 Worm   115 GASGAPAFGSCTSMDNIWDWLSQVLIPGIY----------WTETSNSTDNENMIYYE-NRLLGEP 168

  Fly   214 RLRQLRTESNRLGLSLPVFT--ERDFSESWTLPYERVPYTDKYWP--------IYTPWLPSVSVA 268
            |:|.|:..::    |..|..  :|:..|.:....|::  .||...        ||       :.|
 Worm   169 RIRMLKVTND----SCTVMKSFQREIKECFANYEEKL--EDKTMVGDGSVDAFIY-------ATA 220

  Fly   269 RDNLLMGINHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADA 333
            ::  |..:..||.:.:|......:.|......::...|..|....|:|..:.|:.:||:||||:.
 Worm   221 KE--LENLKTVGTIASYGGGGFVQRLPVAGSTEAQSAIATLKANRWIDRGSRAIIVDFALYNANI 283

  Fly   334 NTFTVCTLWVE-----------------KFPYQYPDGHTRIESHTFVEQLREFTKFGMLMVFVFV 381
            |.|.|..|..|                 ...|| ..|.||:       .:.|....|.::.|:|
 Worm   284 NLFCVVKLLFELPASGGVITTPKLMTYDLLTYQ-TSGGTRM-------MIFEGIFCGFILYFIF- 339

  Fly   382 VTWLQFTKAFFLKVWYDPRQLKTLWVQVDAMIVALSLVVGMIMSVRDNL--VQKMIKSVEIAVVV 444
                   :..|....:....|...|..||.:::..| |..:|:||....  |.::...:|..:..
 Worm   340 -------EELFAIGRHRLHYLTQFWNLVDVVLLGFS-VATIILSVNRTKTGVNRVNSVIENGLTN 396

  Fly   445 DFLDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVITVIFI 509
            ...|....::.:||.  :....|.:..::::|.:..:.|....:.|:..:...:....|:..:|.
 Worm   397 APFDDVTSSENSYLN--IKACVVFVAWVKVFKFISVNKTMSQLSSTLTRSAKDIGGFAVMFAVFF 459

  Fly   510 IA--------IGIATVTINGNYTSNFRDFPKGIVTVTCFAFGYT-----NLVYPPDIFYGGEWLG 561
            .|        .|......:..|.|.|     .::.:....|.::     |..:.|..|
 Worm   460 FAFAQFGYLCFGTQIADYSNLYNSAF-----ALLRLILGDFNFSALESCNRFFGPAFF------- 512

  Fly   562 ILLYTIMGFVVKYMLINLIVSMMRDQMASVKAD-RDKKVRQRITFWQFLRV-------------- 611
             :.|.   |.|.::|:|:.::::.|....|||: ..||..:.|..|...:|
 Worm   513 -IAYV---FFVSFILLNMFLAIINDSYVEVKAELARKKDGEGILDWFMNKVRGLTKRGKRPDAPG 573

  Fly   612 EYAHFINYIVKVFHCQKGYQRKN------------------RTVAQNI--------QRKLNSNE- 649
            |.|.:.:|  |:...:.||..|:                  ..||::|        ::|.|..|
 Worm   574 EDATYEDY--KLMLYRAGYAEKDINEAFTRFNVTSMTEHVPEKVAEDIADEVARMTEQKRNYMEN 636

  Fly   650 ------LKRRKTKI-SSIYSETIYVMPIDKDLEQMKYRERIER-----TFTLAAILHTQMELME 701
                  |.||..:: .|::|....:..::..|:.:: ::|:::     ...|:|:|..|:...|
 Worm   637 HRDYANLNRRVDQMQESVFSIVDRIEGVNATLQTIE-KQRVQQQDGGNLMDLSALLTNQVRNRE 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	94/477 (20%)
pkd-2	NP_502838.3	PKD_channel	119..538	CDD:285288	94/479 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46093
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820