Protein Alignment brv1 and lov-1

DIOPT Version :10

• Sequence 1: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: NP_496184.3
• Gene: lov-1 / 174576
• WormBaseID: WBGene00003058
• Length: 3284
• Species: Caenorhabditis elegans
• Alignment Length: 787
• Identity: 150/787 - (19%)
• Similarity: 302/787 - (38%)
• Gaps: 150/787 - (19%)

  Fly    13 TLIIIAICVACIWMF-SGFRHEYGKFNMILVAFLAVTLLQILIFTPIK-----FTIMSLDAAFWP 71
            |:|:..:.:..|::. :|........|...:.||...:|..::|.|||     |.|:....:...
 Worm  2556 TIIVFPVLMGLIYISGAGMSLMDDLANSFYIRFLISLILWAVVFEPIKGLIWAFLILKTRKSHKI 2620

  Fly    72 AHQAPETPDENANVDTFMDNLRLRL-RTLRSELMITERHRNERVNLKYRLITEELWLTGKLFLVY 135
            .::..|........:||:.|...:: :.|.:|:....:.|:.. |.|.|  .|:|::|.:..|.
 Worm  2621 INKLEEALLRAKPAETFLRNPYGKIEKGLGTEIADVTKLRDTE-NRKMR--DEQLFITIRDMLC- 2681

  Fly   136 FFMALAFFDELLY---------FNTEATELL--FQCNHGDAFGLLSVGDVPDIYFF----VVSSL 185
            ||.:|.....|.|         :..|.:.:|  .|.|:||. ..:|:....|.:.:    :.::|
 Worm  2682 FFASLYIMVMLTYYCKDRHGYWYQLEMSTILNINQKNYGDN-TFMSIQHADDFWDWARESLATAL 2745

  Fly   186 VLAFTDGKNTSGGAPWIHAEGTRLLGVVRLRQLRTES--------------NRLGLSLPVFTERD 236
            :.::.||....|...:::.:.:|.:|:..:||:||:.              |..|..|....|..
 Worm  2746 LASWYDGNPAYGMRAYMNDKVSRSMGIGTIRQVRTKKSAECTMFKQFQGYINDCGEELTSKNEEK 2810

  Fly   237 ---FSESWT-LPYER-VPYTDKYWPIYTPWLPSVSVARDNLLMGINHVGHMFNYPESKGYKVLLS 296
               ....|| |..|. ...:|:|....:..|.:.:|:           |.:::| ...||.:.:|
 Worm  2811 TLYMQAGWTELESENGTDASDEYTYKTSEELSTETVS-----------GLLYSY-SGGGYTISMS 2863

  Fly   297 DTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFTVCTLWVE------KFPYQYPDGHT 355
            .|:.:.:.:.:.|..:.|:|.:|.|:.::||.|||..|.|:|..|.||      ..|..:.:...
 Worm  2864 GTQAEIITLFNKLDSERWIDDHTRAVIIEFSAYNAQINYFSVVQLLVEIPKSGIYLPNSWVESVR 2928

  Fly   356 RIESH----TFVEQLREFTKFGMLMVFV-----------FVVTWLQFTKAFFLKVW------YDP 399
            .|:|.    |.|:.......|..:::||           .|:|.::.|:..|..|:      :.|
 Worm  2929 LIKSEGSDGTVVKYYEMLYIFFSVLIFVKEIVFYLYGRYKVITTMKPTRNPFKIVYQLALGNFSP 2993

  Fly   400 RQLKTLWVQVDAMIVALSLVVGMIMSVRDNLVQKMIKSVEIAVVVDFLDFREPAQLAYLEDVVTG 464
                  |..:|.::.||::...:..::|.....:.::.........:::..|......:......
 Worm  2994 ------WNFMDLIVGALAVASVLAYTIRQRTTNRAMEDFNANNGNSYINLTEQRNWEIVFSYCLA 3052

  Fly   465 LAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVITVIFIIAIGIATVTINGNYTSNFRD 529
            .||...:.::.::|:|:....:...|:..|..|::...:..:.|.:........:.||....:|.
 Worm  3053 GAVFFTSCKMIRILRFNRRIGVLAATLDNALGAIVSFGIAFLFFSMTFNSVLYAVLGNKMGGYRS 3117

  Fly   530 FPKGIVTVTCFAFGYTNL--VYPPDIFYGGEWLGILLYTIMGFVVKYMLINLIVSMMRDQMASVK 592
            ......|......|..::  :.|...|   .::.|:||.|.|   ..:::.|.|:::..:...::
 Worm  3118 LMATFQTALAGMLGKLDVTSIQPISQF---AFVVIMLYMIAG---SKLVLQLYVTIIMFEFEEIR 3176

  Fly   593 ADRDKKVRQRITFWQFLRVEYAHFINYIVK---------------VFHCQKGYQRKNRTVAQNIQ 642
            .|.:|:...         .|....|.|..|               :...||.::..:..||:
 Worm  3177 NDSEKQTND---------YEIIDHIKYKTKRRLGLLEPKDFAPVSIADTQKDFRLFHSAVAK--- 3229

  Fly   643 RKLNSNELKRRKTKISSIYSETIYVMPIDKDLEQMKYRERIERTFTL-----AAILHTQMELMER 702
                .|.|..|.|::..               .|.:|:.:....:||     :||..|..:..::
 Worm  3230 ----VNLLHHRATRMLQ---------------TQGQYQNQTVINYTLSYDPVSAIHETGPKRFQK 3275

  Fly   703 LMFGDEE 709
            ....|.|
 Worm  3276 WRLNDVE 3282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	Polycystin_dom	167..363	CDD:466668	50/228 (22%)
		PKD_channel	364..591	CDD:462341	37/245 (15%)
lov-1	NP_496184.3	GPS	2177..2226	CDD:197639
		PLAT_polycystin	2288..2413	CDD:238850
		Polycystin_dom	2724..2930	CDD:466668	47/217 (22%)
		PKD_channel	2992..3175	CDD:462341	29/194 (15%)