DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv1 and Pkd1l1

DIOPT Version :9

Sequence 1:	NP_649116.1	Gene:	brv1 / 40116	FlyBaseID:	FBgn0036874	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_036013024.1	Gene:	Pkd1l1 / 171395	MGIID:	2156538	Length:	2551	Species:	Mus musculus

Alignment Length:	565	Identity:	119/565 - (21%)
Similarity:	202/565 - (35%)	Gaps:	157/565 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 NMILVAFLAVTL---LQILIFT-----PIKFTIMSLDAA-----------------FWPAHQAPE 77
            :::..||:...|   |..|:|.     ..||...||..|                 ..|...:|:
Mouse  1870 SLVCCAFITQPLMICLAALVFAWKRKHDSKFFTESLQDATKGLDLELEEHSRTRVPLSPISYSPD 1934

  Fly    78 TPDENANVDTFMDNLRLRLRTLR-------SELMIT-ERHRNERVNLKYRLITEELWLTGKLFLV 134
            |.:|...|..    .|.|.|.||       ::|.:| ||.|.|.:   .:....::.....:.|:
Mouse  1935 TAEEAERVLA----TRQRERHLRWAQTPSKAKLRVTGERLRRESI---MQAALRDMTTHSIMLLL 1992

  Fly   135 YFFMALAFF--DELLYFNTEATELLFQCNHGDAFGLLSVGDV---PDIYFFVVSSLVLAFTDGKN 194
            ..|:|...|  .|:...:........:.||       |:||:   .|.:.:.:|:|:......:.
Mouse  1993 LLFIAYGRFCPGEISLNHAIRKAFTRKANH-------SLGDLSSTEDWWDWTLSTLLDELYPERT 2050

  Fly   195 TS---GGAPWIHAEGTRLLG--VVRLRQLRTESNRLGLSLPVFTERDFSESWTLPYERVPYTDKY 254
            ::   |..|........|:|  ||:|.::   |.....:.|    |.|||          ..:..
Mouse  2051 SARAWGAQPGALGGQCHLIGPPVVKLLKI---SAGTACTPP----RPFSE----------LVEDV 2098

  Fly   255 WPIYTPWLPSVSVARDNLLMGINHVGHMFNYPESKG-----YKVLLSDTRHKSLKIIDYLMKKNW 314
            .|:::   ..:.:...|:..|         .||:.|     |...|..|||::...:..|....|
Mouse  2099 LPMHS---NDLDLENQNVSPG---------GPETCGVKKESYMHSLGKTRHEAHAALTALRASKW 2151

  Fly   315 LDANTTALFMDFSLYNADANTFT--------------VCTLWVEKFPYQYPDGHTRIESHTFVEQ 365
            :|.:|.|:.:.|:|||.....||              |.:..||.|...|.|...:     ::..
Mouse  2152 IDHSTRAMSVHFTLYNPPTQLFTSVILGTECLPSGGLVPSFLVESFRIFYSDSALK-----YLLM 2211

  Fly   366 LREFTKFGMLMVFVFVVTWLQFTKAFFLKVWYDPRQLKTLWVQVDAMIVAL----------SLVV 420
            |.|.....:.::.:....|...||. .|..|..||.    |:::..:.||:          :|.|
Mouse  2212 LSELLFLVLNVIHLCFQLWGMTTKG-ILSYWRKPRH----WLELSMVGVAIAYYAASGHLTTLAV 2271

  Fly   421 GMIMSVRDNLVQKMIKSVEIAVVVDFLDFREPAQ--------LAYLEDVVTGLAV-----ALVTM 472
            .:.......|.|::   |:|.::|.:.......|        |.|:. :::.|:.     |:...
Mouse  2272 NITDQFHKGLYQRL---VDIGLMVSWHQRARCLQGILLFLWMLKYVH-LLSSLSTMTPFSAVTCF 2332

  Fly   473 RLWKVLQFSAT----------FQLFTKTI-----AMAWDALLCTF 502
            .|::||...|.          |.|||.|:     |.|:..||..|
Mouse  2333 PLFRVLLVGALLLAAHYHSRWFLLFTGTLSHGTSAEAFPGLLLQF 2377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	85/403 (21%)
Pkd1l1	XP_036013024.1	PCC	<167..622	CDD:188093
		REJ	<835..976	CDD:366875
		GPS	1387..1425	CDD:413374
		PLAT	1493..1611	CDD:412108
		PKD_channel	2023..>2331	CDD:400395	71/350 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820