Protein Alignment brv1 and PKD1L1

DIOPT Version :9

• Sequence 1: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: XP_016867287.1
• Gene: PKD1L1 / 168507
• HGNCID: 18053
• Length: 2920
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 99/528 - (18%)
• Similarity: 189/528 - (35%)
• Gaps: 113/528 - (21%)

  Fly    18 AIC----VACIWMFSGF-RHEYGKFNMI----LVAFLAVTLLQILIFTPIKFTIMSLDAAF---- 69
            |||    :||. :.:|| .:.:|:...:    |::...|..  |.|..|:...:|:|..|:
Human  2198 AICGTASLACS-LGTGFLAYRFGQEQCVQWLHLLSLSVVCC--IFITQPLMVCLMALGFAWKRRA 2259

  Fly    70 ------------------------W---PAHQAPETPDENANVDTFMDNLRLRLRTLR-----SE 102
                                    |   |...:...||....|:..: ..|.:.|.||     |:
Human  2260 DNHFFTESLCEATRDLDSELAERSWTRLPFSSSCSIPDCAGEVEKVL-AARQQARHLRWAHPPSK 2323

  Fly   103 LMITERHRNERVNLKYRLITEELWLTGKLFLVYFFMALAFFDELLYFNTEATELLFQCNHGDAFG 167
            ..:....:..|...:.|....::.:...:.|:...:....|.:..|...:|....|..|..:..|
Human  2324 AQLRGTRQRMRRESRTRAALRDISMDILMLLLLLCVIYGRFSQDEYSLNQAIRKEFTRNARNCLG 2388

  Fly   168 LLSVGDVPDIYFFVVSSLVLAFTDGKNTSGGAPWIHAEGTR---------LLGVVRLRQLRTESN 223
              .:.::.|.:.:.:::|:    ||. ..||.|.....|.:         |:|...:|||:....
Human  2389 --GLRNIADWWDWSLTTLL----DGL-YPGGTPSARVPGAQPGALGGKCYLIGSSVIRQLKVFPR 2446

  Fly   224 RLGLSLPVFTERDFSESWTLPYERVPYTDKYWPIYTPWLPSVSVARDNLLMGINHVGHMFNYPES 288
            .|     ....|.||   .|..:.:|...          |.|....:..|:...:.....|.|..
Human  2447 HL-----CKPPRPFS---ALIEDSIPTCS----------PEVGGPENPYLIDPENQNVTLNGPGG 2493

  Fly   289 KGYK----VLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFTVCTLWVEKFP-- 347
            .|.:    :.|..||.::...:..|....|:|.:|.|:.:.|:|||.....||..:|.||..|
Human  2494 CGTREDCVLSLGRTRTEAHTALSRLRASMWIDRSTRAVSVHFTLYNPPTQLFTSVSLRVEILPTG 2558

  Fly   348 ----------YQYPDGHTRIESHTFVEQLREFTKFGMLMVFVFVVTWLQFTKAFFLKVWYDPRQL 402
                      :......:.::.|..:.||   ....:.::.:.|..:....|. .|..|..||.
Human  2559 SLVPSSLVESFSIFRSDSALQYHLMLPQL---VFLALSLIHLCVQLYRMMDKG-VLSYWRKPRN- 2618

  Fly   403 KTLWVQVDAMIVALS--LVVGMIMSVRDNLVQKMIKSVEIAVVVDFLDFREPAQLAYLEDVVTGL 465
               |:::..:.|:|:  .|.|.::::..::..:..:.:..|    |:|....|........:.|:
Human  2619 ---WLELSVVGVSLTYYAVSGHLVTLAGDVTNQFHRGLCRA----FMDLTLMASWNQRARWLRGI 2676

  Fly   466 AVALVTMR 473
            .:.|.|::
Human  2677 LLFLFTLK 2684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	65/336 (19%)
PKD1L1	XP_016867287.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820