DRSC/TRiP Functional Genomics Resources

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Protein Alignment brv1 and PKD1L2

DIOPT Version :10

Sequence 1:NP_649116.1 Gene:brv1 / 40116 FlyBaseID:FBgn0036874 Length:728 Species:Drosophila melanogaster
Sequence 2:NP_443124.4 Gene:PKD1L2 / 114780 HGNCID:21715 Length:2463 Species:Homo sapiens


Alignment Length:647 Identity:137/647 - (21%)
Similarity:250/647 - (38%) Gaps:148/647 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 CVACIWMF----SG--------FRHEYGKFNMI--LVAFLAVTLLQILIFT-PIKFTIMSLDAAF 69
            |:...|:.    ||        :...||:.:.:  |:: :||:.::.:..| |:|  ::.. |||
Human  1818 CILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLIS-MAVSFVESMFVTQPLK--VLGF-AAF 1878

  Fly    70 W-----------------PAHQAPETP------DENANVDTFMDNLRLRLRTLRSELMITERHRN 111
            :                 |.|.....|      ..|::.|.:...|     |...|.|.|...:.
Human  1879 FALVLKRVDDEEDTVAPLPGHLLGPDPYALFRARRNSSRDVYQPPL-----TAAIEKMKTTHLKE 1938

  Fly   112 ERVNLKYRLITEELWLTGKLFLVYFFMALAFFDELLYFNTEATELLFQCNHGDAFGLLSVGDVPD 176
            ::.   :.||.|.|...|.|:::   :.:|:...    :..|..|.....|....|...|....:
Human  1939 QKA---FALIREILAYLGFLWML---LLVAYGQR----DPSAYHLNRHLQHSFTRGFSGVLGFRE 1993

  Fly   177 IYFFVVSSLVLAFTDGKNTSGGAPWIHAEG-TRLLGVVRLRQLRTESN---------------RL 225
            .:.:..::||      .|..|..|....:| ::|:|..::||:|.:.:               |.
Human  1994 FFKWANTTLV------SNLYGHPPGFITDGNSKLVGSAQIRQVRVQESSCPLAQQPQAYLNGCRA 2052

  Fly   226 GLSLPVFTERDFSESW---TLPY-ERVPYTDKY--------WPIYTPWLPSVSVARDNLLMGINH 278
            ..||......|:.|.|   ||.. ...|...:|        :||:                    
Human  2053 PYSLDAEDMADYGEGWNATTLSNGSSFPQAWQYQSQDQRQGYPIW-------------------- 2097

  Fly   279 VGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFTVCTLWV 343
             |.:..| ...||.|.|...|..:.:|:.||....||||.|.|:|::.::|||:.|.|.:.||.:
Human  2098 -GKLTVY-RGGGYVVPLGTDRQSTSRILRYLFDNTWLDALTRAVFVESTVYNANVNLFCIVTLTL 2160

  Fly   344 EKFPYQYPDGHTRIES---HTFVEQLREFTKFGMLMVFVFVVTWL--------QFTKAFFLKVWY 397
            |.........|..::|   :.|.:....|.....|:.|:|::.::        :.|..:|...| 
Human  2161 ETSALGTFFTHAALQSLRLYPFTDGWHPFVVAAELIYFLFLLYYMVVQGKRMSKETWGYFCSKW- 2224

  Fly   398 DPRQLKTLWVQVDAMIVALSLVVGMIMSVRDNLVQKMIKSVEIAVVVDFLDFREPAQLAYLEDVV 462
            :..:|..:.....|:.|   .|...:::.||  :|:.....|     :.:.|.|.|........:
Human  2225 NLLELAIILASWSALAV---FVKRAVLAERD--LQRCRNHRE-----EGISFSETAAADAALGYI 2279

  Fly   463 TGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVITVIFIIAIGIATVTING----NY 523
            ....|.|.|::||.:|:.:....:.|..:..||..:....::.:..::|..||:..|.|    :|
Human  2280 IAFLVLLSTVKLWHLLRLNPKMNMITAALRRAWGDISGFMIVILTMLLAYSIASNLIFGWKLRSY 2344

  Fly   524 TSNFRDFPKGIVTVTCFAFGYTNLV-YPPDIFYGGEWLGILLYTIMGFVVKYMLINLIVSMM 584
            .:.| |..:.:|::....|.|..:: |.|.:   |.:|.......|.|||    :||.:|::
Human  2345 KTLF-DAAETMVSLQLGIFNYEEVLDYSPVL---GSFLIGSCIVFMTFVV----LNLFISVI 2398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
brv1NP_649116.1 Polycystin_dom 167..363 CDD:466668 52/226 (23%)
PKD_channel 364..591 CDD:462341 49/234 (21%)
PKD1L2NP_443124.4 CLECT 28..153 CDD:214480
Gal_Rha_Lectin_PKD1L2 157..253 CDD:438688
REJ <581..898 CDD:366875
GPS 1277..1316 CDD:470616
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 1279..1326
PLAT_polycystin 1387..1506 CDD:238850
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1622..1646
Polycystin_dom 1984..2180 CDD:466668 52/223 (23%)
PKD_channel 2182..2404 CDD:462341 50/236 (21%)
Channel pore-region 2344..2366 6/22 (27%)
Interaction with GNAS and GNAI1. /evidence=ECO:0000269|PubMed:15203210 2383..2463 7/20 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2435..2463
Blue background indicates that the domain is not in the aligned region.

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