DRSC/TRiP Functional Genomics Resources

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Protein Alignment brv1 and PKDREJ

DIOPT Version :10

Sequence 1:NP_649116.1 Gene:brv1 / 40116 FlyBaseID:FBgn0036874 Length:728 Species:Drosophila melanogaster
Sequence 2:NP_006062.1 Gene:PKDREJ / 10343 HGNCID:9015 Length:2253 Species:Homo sapiens


Alignment Length:723 Identity:145/723 - (20%)
Similarity:268/723 - (37%) Gaps:164/723 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 CVACIW--------------MFSGFRHEYGKFNMILVAFLAVTLLQILIFTPIKFTIMSLDAAFW 70
            ||...|              :|.|..:.|.|....|.|........:|:..|.|..::|......
Human  1576 CVYVAWFLVFATSSISSFFIVFYGLTYGYDKSIEWLFASFCSFCQSVLLVQPSKIILLSGFRTNK 1640

  Fly    71 PAHQAPETPDENANVDTFMDNLRLRLRTLRSELMITERHRNERVNLK----YRLITEE------- 124
            |.:      .:|.:..|......:||..:|......:|..::.|.::    |:.:||:       
Human  1641 PKY------CKNLSWSTKYKYTEIRLDGMRMHPEEMQRIHDQIVRIRGTRMYQPLTEDEIRIFKR 1699

  Fly   125 ---LWLTGKLFLVYFFMALAFFDELLYFNTEATELLFQCNHGDAF------------GLLSVGDV 174
               :.....|||.|......|...||.       |:....|.|.|            .|.:|..:
Human  1700 KKRIKRRALLFLSYILTHFIFLALLLI-------LIVLLRHTDCFYYNQFIRDRFSMDLATVTKL 1757

  Fly   175 PDIYFFVVSSLVLAFTDGKNTSGGAPWIHAEGTRLLGVVRLRQLRTESN-RLGLSLPVFTE---- 234
            .|||.::.|.|:....:..|.:    ::....:::||:..:||:|.:|: ::.|....|.:    
Human  1758 EDIYRWLNSVLLPLLHNDLNPT----FLPESSSKILGLPLMRQVRAKSSEKMCLPAEKFVQNSIR 1818

  Fly   235 ----------------RDFSESWTLPYERVPYTDK-----------YWPIYTPWLPSVSVARDNL 272
                            :::|..|.       ..||           |.|..|.||        ..
Human  1819 REIHCHPKYGIDPEDTKNYSGFWN-------EVDKQAIDESTNGFTYKPQGTQWL--------YY 1868

  Fly   273 LMGINHV----GH-MFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNAD 332
            ..|:.|.    |: ::.:||.:.:.   |..|.|.|:      :.||||..|.|:.::.:.:|.|
Human  1869 SYGLLHTYGSGGYALYFFPEQQRFN---STLRLKELQ------ESNWLDEKTWAVVLELTTFNPD 1924

  Fly   333 ANTFTVCTLWVEKFPYQYPDGHTRIESHTFVEQLREFTKFGMLMVFVFVVTWLQFTKAFFLKVWY 397
            .|.|  |::.|.....|....:|.|..|:|  .|.:|.:.....::::|...:     |||....
Human  1925 INLF--CSISVIFEVSQLGVVNTSISLHSF--SLADFDRKASAEIYLYVAILI-----FFLAYVV 1980

  Fly   398 DP----RQLKTLWVQ--VDAMIVALSLV--VGMIMSVRDNLVQKMIKSVEIAVVVDFLDFREPAQ 454
            |.    .|.:..:|:  .:.:..||..:  |.:::.:|.:.:...|....::...||:.|...:|
Human  1981 DEGCIIMQERASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATGIIRFYLSNPEDFIPFHAVSQ 2045

  Fly   455 LAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLC--TFVITVIFIIAIGIATV 517
            :.::..::.|..:.|..::..:..:|....:|..:.|..|... :|  .||::|.|.:.:....:
Human  2046 VDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPG-ICHMAFVVSVYFFVYMAFGYL 2109

  Fly   518 TINGNYTSNFRDFPKGIVTVTCFAFGYTNLVYPPDIFYGGEWLGILLYTIMGFVVKYMLINL--- 579
             :.|.:..|:.:......||    |.|....:....|.....||:|..:....|:..:||||   
Human  2110 -VFGQHEWNYSNLIHSTQTV----FSYCVSAFQNTEFSNNRILGVLFLSSFMLVMICVLINLFQA 2169

  Fly   580 -IVSMMRDQMASVKADRDKKV-------RQRITFWQFL------RVEYAHFINYIV----KVFHC 626
             |:|...:....|..:...:|       |:..|.:.||      :.|...||:.:.    |..|.
Human  2170 VILSAYEEMKQPVYEEPSDEVEAMTYLCRKLRTMFSFLTSQSKAKDEPEFFIDMLYGQPEKNSHR 2234

  Fly   627 QKGYQRKN 634
            ..|.:.:|
Human  2235 YLGLKTRN 2242

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
brv1NP_649116.1 Polycystin_dom 167..363 CDD:466668 50/232 (22%)
PKD_channel 364..591 CDD:462341 46/240 (19%)
PKDREJNP_006062.1 T2SSN 38..>141 CDD:446022
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 154..177
REJ 243..711 CDD:366875
PLAT_polycystin 1231..1346 CDD:238850
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1494..1562
Polycystin_dom 1750..1955 CDD:466668 51/236 (22%)
PKD_channel 1956..2178 CDD:462341 45/232 (19%)
Blue background indicates that the domain is not in the aligned region.

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