DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv1 and pkd1

DIOPT Version :9

Sequence 1:	NP_649116.1	Gene:	brv1 / 40116	FlyBaseID:	FBgn0036874	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_017952982.2	Gene:	pkd1 / 100494429	XenbaseID:	XB-GENE-483409	Length:	4354	Species:	Xenopus tropicalis

Alignment Length:	681	Identity:	137/681 - (20%)
Similarity:	255/681 - (37%)	Gaps:	169/681 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LTLIIIAICVA-CIWMFSGFRHEYGKFNMILVAFLAVTLLQILIFTPIKFTIMSLDAAFWPAHQA 75
            |:..::..|.| ..|:..||....|.  |.|::.:...|....|..|:|....:|..|.......
Frog  3546 LSCFLLLCCFAVSSWIGVGFTSSVGL--MWLISGIFSFLCSFFILEPLKVLFEALYFALVAKRLH 3608

  Fly    76 PETPD---ENANVDTFMDNLRLRLRTLRSELMITERHRNERVNLKYRLITEELWLTGKLFLVYFF 137
            ||..|   |...|:...:.: .::|..:...:...|...::|.|.:|::...|     :|:::|.
Frog  3609 PEEEDTLVECPIVEQVSERI-TKVRPPQGFALFQAREEAQKVKLLHRMLKNLL-----VFMLFFL 3667

  Fly   138 MAL------------AFFDELLYFNTEATELLFQCNHGDAFGLLSVGDVPDIYFFVVSSLVLAFT 190
            :.|            |:..:........|.........|.|.:.:            |.::|
Frog  3668 VILITNYGEAPKNNSAYLLQRSISQELGTHKFLHIKRSDEFWVWA------------SEMLL--- 3717

  Fly   191 DGKNTSGGAPWIH-----AEG-TRLLGVVRLRQLRTE-------SNRL---GLSLPVFTERDFSE 239
                     |::|     .:| :.:|||.||||:|.:       |.:|   |.|.|...:....:
Frog  3718 ---------PYVHHNQPLQQGYSSMLGVARLRQIRLKEALPTSCSLQLFSAGRSCPELFDDAIFK 3773

  Fly   240 SWTLPYERVPYTDKYWPIYTPWLPSVSVARDNLLMGINHVGHMF----NYPESKGYKVLLSDTRH 300
            |.|||       ...|. |:|  |             :|.|..:    ::.::.||..||..::.
Frog  3774 SATLP-------SLNWS-YSP--P-------------DHTGAWYWGFLSFYDTSGYVQLLQGSQK 3815

  Fly   301 KSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFTVCTLWVEKFPY-----------QYPDGH 354
            .:.::::.|.:..|:|..|.|||::||||:.....:...||.:| ||.           .:|  .
Frog  3816 DNEELLEELQQSYWIDNLTRALFVEFSLYSPGVELYASVTLLLE-FPLAGRALPSVNIRAFP--L 3877

  Fly   355 TRIESHTFVEQLREFTKFGMLMVFVFVVTWLQFTK----AFFLKVWYDPRQLKTLWVQVDAMIVA 415
            .|:.|.|.:  |.....|.|:.|..||::.....:    .:|.:.|...:.|.|: :.|..::|.
Frog  3878 LRLTSGTHL--LLVMMVFLMMFVVYFVLSECLIIRKEGLQYFTRFWNYVQWLLTV-LAVCTVVVY 3939

  Fly   416 LSLVVGMIMSVRDNLVQKMIKSVEIAVVVDFLDFREPAQLAYLEDVVTGLAVAL---VTMRLWKV 477
            ||..     |:.|....:.:|..|..|.:        .|:.:|.:....|:.::   :|::..:.
Frog  3940 LSKA-----SLADRQWDRYLKDKEAFVSL--------YQVGFLGNTFHSLSASILFVLTVKAAQQ 3991

  Fly   478 LQFSATFQLFTKTIAMAWDALLCT--FVITVIFIIA-IGIATVTINGNYTSNFRDFPKGIVTVTC 539
            ::|...:..|.||:::|...|...  .|..::.:.| :|.   .:..:....|..|...|:|:..
Frog  3992 MRFIREWSAFGKTLSLAARELCAASGAVFGLVLVYAQLGF---LLFSSSWEKFHSFGSSILTLFA 4053

  Fly   540 FAFGYTNLVYP-------PDIFYGG-----EWLGILLYTIMGFVVK------------------Y 574
            .|.|..:|..|       ..:::..     .|  |||......::.                  |
Frog  4054 VARGNVSLKAPFPYSSTISHLYFASYLVLEVW--ILLRLFAAVLINSYRQVRLEMFRPAFEPQDY 4116

  Fly   575 MLINLIVSMMRDQMASVKADRDKKVRQRITF 605
            .::.|.:..:|..|...|.   |:.|.::.|
Frog  4117 EMVELFLRRLRIWMGVSKV---KEFRHKVRF 4144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	101/496 (20%)
pkd1	XP_017952982.2	LRR_8	<83..114	CDD:404697
		leucine-rich repeat	83..103	CDD:275378
		leucine-rich repeat	104..127	CDD:275378
		PCC	108..2722	CDD:188093
		leucine-rich repeat	128..140	CDD:275378
		GPS	2996..3045	CDD:413374
		PLAT_polycystin	3103..3222	CDD:238850
		PKD_channel	3699..4102	CDD:400395	98/473 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010