DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv1 and Pkd1l3

DIOPT Version :9

Sequence 1:	NP_649116.1	Gene:	brv1 / 40116	FlyBaseID:	FBgn0036874	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_038954217.1	Gene:	Pkd1l3 / 100362565	RGDID:	2324490	Length:	2183	Species:	Rattus norvegicus

Alignment Length:	737	Identity:	151/737 - (20%)
Similarity:	276/737 - (37%)	Gaps:	184/737 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FYLTLIIIAIC--VACIWMFSGFRHEYGKFNMILVAFLAVTLLQ-ILIFTPIKFTIMSL------ 65
            |::||..:.:.  .|..|:.|                :.:::|| |.|..|||...::|
  Rat  1538 FFITLYSLELSRDQATSWVIS----------------MMLSVLQDIFICQPIKVIFLTLLFSLMA 1586

  Fly    66 ----------------DAAFW---PAHQAPETPDENANVDT--FMDNLRLRLRTL-RSELMITER 108
                            ..|.|   |: .||...|:|..:.|  .|::|..|.:.: |..|.:
  Rat  1587 NHMPWLTKDKEHHARRIVALWAKCPS-SAPGLRDKNNPIYTAPAMNHLDRRTKKVWRKRLFL--- 1647

  Fly   109 HRNERVNLKYRLITEELWLTGKLFLVY-------FFMALAFFDELLY----------FNTEATEL 156
                   |....:.:.|:||..:..||       ||:..|.:....:          |...|...
  Rat  1648 -------LTAGSLVQILFLTLLMTTVYSAKDSSRFFLHRAVWKRFSHGFSEIKAVEDFYPWANRT 1705

  Fly   157 LFQCNHGDAFGLLSVGDVPDIYFFVVSSLVLAFTDGKNTSGGAPWIHAEGTRLLGVVRLRQLRTE 221
            |....:||..|.:                    |||.:.             |||.|.|||:|..
  Rat  1706 LLPNLYGDYRGFI--------------------TDGNSF-------------LLGNVLLRQIRIP 1737

  Fly   222 SNR---LGL-----SLPVFTE--RDFSESWTLPYERVPYTDKYWPIYTPWLPSVSVARDNLLMGI 276
            ::.   :.|     |.|...|  .::...|..|...:...|..|...:|          ..|.|.
  Rat  1738 NDTHSPVSLHEHMNSYPQHQEDRENYGAGWVPPDTNITKADSIWHYQSP----------ESLGGY 1792

  Fly   277 NHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFTVCTL 341
            ...|.:..| ...||.|.|......:.:::.:|.:::|||..|.|||::|:::||:.|...:.||
  Rat  1793 PIQGEVTTY-SGGGYVVRLGRNHSAATRVLQHLEQRHWLDHYTKALFVEFTVFNANVNLLCMVTL 1856

  Fly   342 WVEK------FPYQYPDGHTRIESHTFVEQLREFTKFGMLMVFVFVVTWLQFTKAFFLKVWYDPR 400
            .:|.      |.....|..|.::|..     |.|......:.:..:|.:..|.:...||     |
  Rat  1857 ILESSGVGTFFTSLRLDSLTSLQSSE-----RGFAWIISQVAYYLLVCYYAFVQGCRLK-----R 1911

  Fly   401 QLKTLWVQ----VDAMIVALSL-VVGMIM---SVRDNLVQKMIKSVEIAVVVDFLDFREPAQLAY 457
            |....:.:    :|..|:..|. ::|:.|   |:....:|:..:..:     .|:.|.|..::..
  Rat  1912 QGLAFFTRRRNILDTSIILTSFSILGLNMQSLSLLHTNMQQYRRDPD-----GFISFSEALRVNS 1971

  Fly   458 LEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVITVIFIIAIGIATVTINGN 522
            :...:.|..:...|:|:|.:|:..|..|:..||:..|||.:|...:|.:|.:.:..:....:.|.
  Rat  1972 VATHLMGFLLLFATVRVWDLLRHHARLQVINKTLTKAWDEVLGFIMIIMILLSSYAMTFNLLFGW 2036

  Fly   523 YTSNFRDFPKGIVTVTCFAFG---YTNLVYPPDIFYGGEWLGILLYTIMGFVVKYMLINLIVSMM 584
            ..|:::.|...:|||.....|   :..:|....:.  |.:|.:....:||.|:    |||.||.:
  Rat  2037 SISDYQSFFSSVVTVVGLLVGIPKHKEVVALSPVL--GSFLVLSNIILMGLVI----INLFVSAI 2095

  Fly   585 RDQMASVKADRDKKVRQRITFWQFLRVEYAHFINYIVKVFHCQKGYQRKNRTVAQNIQRKLNSNE 649
                 .:...:::|..::          .|...:.:::......|.::..:..::.......|:.
  Rat  2096 -----LIVFGKERKACEK----------EATLTDMLLQKLSSLLGIRQHQKPASEKHADSTGSSN 2145

  Fly   650 LKRRKTKISSIYSETIYVMPID 671
            |:.|.:|  |:.|:...:.|.|
  Rat  2146 LRERSSK--SMSSDAEVLAPAD 2165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	99/452 (22%)
Pkd1l3	XP_038954217.1	CLECT	37..144	CDD:153057
		Herpes_BLLF1	<215..601	CDD:282904
		GPS	1002..1040	CDD:396408
		PLAT_polycystin	1111..1230	CDD:238850
		PKD_channel	1688..2096	CDD:400395	104/477 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020