DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv1 and pkd1a

DIOPT Version :9

Sequence 1:	NP_649116.1	Gene:	brv1 / 40116	FlyBaseID:	FBgn0036874	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_021333081.1	Gene:	pkd1a / 100149562	ZFINID:	ZDB-GENE-100707-1	Length:	4625	Species:	Danio rerio

Alignment Length:	657	Identity:	137/657 - (20%)
Similarity:	262/657 - (39%)	Gaps:	133/657 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IWMFSGFRHEYGKFNMILVAFLAVTLLQILIFTPIKFTIMSLDAAFWPAHQAPETPD---ENANV 85
            :|:..||..  |...|.|::.:...|...|:..|:|..:..:..:.......||..|   |...|
Zfish  3665 MWLGRGFSE--GVALMWLISCIVSFLSSFLLLEPLKVLLEGVYFSLVVRRLRPEEQDVLVECPRV 3727

  Fly    86 DTFMDNLRLRLRTLRSELMITERHRNERVNLKYRLITEELWLTGKLFLVY--FFMALAFFDELLY 148
            :..:..:. |:|..:...:...|....:|.|.:.::        |.||:|  |.|.:..   |.|
Zfish  3728 ERVVQRIP-RVRPPQGFALSQAREEARKVRLLHTML--------KGFLLYMLFLMVVLL---LNY 3780

  Fly   149 FNTE--ATELLFQCNHGDAF---GLLSVGDVPDIYFFVVSSLVLAFTDGKNTSGGAPWIHAEGTR 208
            .::|  |..|.......|.|   ...::....|::.::.:||:....|.:      ..:...|:.
Zfish  3781 SDSEKDAHRLRLNAQLQDHFLTKHFNNISSREDVWAWLSNSLLPRLLDEQ------VLMEKTGSL 3839

  Fly   209 LLGVVRLRQLRTESNRLGLSLPV---FTERDFSESWTLPYERVPYTDKYWPIYTPWLPSVSVARD 270
            |:|..||||.|.:.     ..||   |.    :.|| ....:..:.:....:...|  |||.|:.
Zfish  3840 LIGRARLRQTRAQP-----ECPVSGYFP----ASSW-FGCVQAGWAESASGLVQNW--SVSTAQS 3892

  Fly   271 NLLMGINHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANT 335
            :   |:.|.|.:..| .|.|:...||.....|..:|:.|....|||..|.|||::|||||.:.:.
Zfish  3893 S---GVWHWGQVSVY-SSSGFVQDLSRKMQDSKNLINQLNTHQWLDPLTRALFLEFSLYNINTDL 3953

  Fly   336 FTVCTLWVEKFPYQYPDGHTRIESHTF-VEQLREFTKFGMLMVFVFVVTWLQFT----------- 388
            .:|.:..:| ||.. ......::..|| :..|.......:.:..:.:|..:.|:
Zfish  3954 LSVFSFLLE-FPVS-ERAQLSLDLKTFSLHTLSHGMDLPLFLTLILLVLLIYFSVREGLLVWKQG 4016

  Fly   389 KAFFLKVWYDPRQLKTLWVQVDAMIVALSLVVGMIMSV---RDNLVQKMIKSVEIAVVVDFLD-F 449
            :.:||:||                  .|:.|..::::|   ..:|.:.::.:.:....:...| |
Zfish  4017 RCYFLRVW------------------NLASVCSLLLAVCVASLHLSRSVVSAQQWRAFLQHRDAF 4063

  Fly   450 REPAQLAYLEDVVTGLAVALVTMRLWKV---LQFSATFQLFTKTIAMAWDALLCTFVITVIFIIA 511
            .:...||....::|.::..|:.:.:.|.   |:|...:.:|.:|:..::..||...|..::|::|
Zfish  4064 TDFFPLAQQNQLLTQMSATLLFLLVLKASHQLRFLREWGVFGRTLRKSFWELLMVAVTLLVFLLA 4128

  Fly   512 IGIATVTINGNYTSN--FRDFPKGIVTV--TCF----AFGYTNLVYPPD-----------IFYGG 557
            .         ::|.:  |....:|..||  |||    :.|...|.:.||           |||
Zfish  4129 Y---------SHTGHLLFHSVMEGYGTVSSTCFKLIGSSGRGLLSWRPDSGSFPCSGSCFIFY-- 4182

  Fly   558 EWLGILLYTIMGFVVKYMLINLIVSMMRDQMASVKAD----RDKKV----RQRITFWQFL--RVE 612
                 :.:|::..|:.::|::.::...|...|.:...    :|.::    .:|:..|..|  ..|
Zfish  4183 -----ISFTLLRLVLLWILMSALLRNYRRARAELYRPAVDLQDYEMVELFLRRLKMWMGLSRTKE 4242

  Fly   613 YAHFINY 619
            :.|.:.:
Zfish  4243 FRHKVRF 4249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	99/469 (21%)
pkd1a	XP_021333081.1	LRR	<68..>167	CDD:227223
		leucine-rich repeat	88..110	CDD:275378
		leucine-rich repeat	111..133	CDD:275378
		leucine-rich repeat	134..157	CDD:275378
		PCC	138..2795	CDD:188093
		leucine-rich repeat	158..170	CDD:275378
		GPS	3106..3155	CDD:197639
		PLAT	3213..3326	CDD:320707
		PKD_channel	3802..4155	CDD:332708	86/403 (21%)
		Atrophin-1	4496..>4606	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820