Protein Alignment Chd3 and CHD1L

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: NP_004275.4
• Gene: CHD1L / 9557
• HGNCID: 1916
• Length: 897
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 242/624 - (38%)
• Similarity: 363/624 - (58%)
• Gaps: 66/624 - (10%)

  Fly   264 GLKLHPFQIEGVSWL--RYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLS 326
            |:.|..:|:|||:||  |:....|  .||.||||||||.||:.....|....:..|||||..|||
Human    43 GIHLRSYQLEGVNWLAQRFHCQNG--CILGDEMGLGKTCQTIALFIYLAGRLNDEGPFLILCPLS 105

  Fly   327 TLTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFI 391
            .|:||:.|::.:||.|.||||.|.|..||.::              ::.:.:.:|:|:||:||..
Human   106 VLSNWKEEMQRFAPGLSCVTYAGDKEERACLQ--------------QDLKQESRFHVLLTTYEIC 156

  Fly   392 SVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLS 456
            ..||:||....|:.|||||||||::..|...:.||::.:.:.|||||||:||:|:||:.||:|:.
Human   157 LKDASFLKSFPWSVLVVDEAHRLKNQSSLLHKTLSEFSVVFSLLLTGTPIQNSLQELYSLLSFVE 221

  Fly   457 SGKFN--DLQTFQAEFTDVSKE-EQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQ 518
            ...|:  ::..|...:.|:.|| |....||::|:|.:|||:||:|...:|.|:|.::...:|::|
Human   222 PDLFSKEEVGDFIQRYQDIEKESESASELHKLLQPFLLRRVKAEVATELPKKTEVVIYHGMSALQ 286

  Fly   519 KKFYKHILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYEMSS-LT 582
            ||:||.||.|:..|...:...:| .|.||:..||||.:|||||.....|.       :|:.. ||
Human   287 KKYYKAILMKDLDAFENETAKKV-KLQNILSQLRKCVDHPYLFDGVEPEP-------FEVGDHLT 343

  Fly   583 KASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDR 647
            :|||||.||.|:|..|.:..||||||||||:||::|:.:::..||.|:|:|||::|:.|..||..
Human   344 EASGKLHLLDKLLAFLYSGGHRVLLFSQMTQMLDILQDYMDYRGYSYERVDGSVRGEERHLAIKN 408

  Fly   648 F-NDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFV 711
            | ..|:   |||||||||||:|:||..|||||..|||:||.||:||.:||||:||.|.|.:.|.:
Human   409 FGQQPI---FVFLLSTRAGGVGMNLTAADTVIFVDSDFNPQNDLQAAARAHRIGQNKSVKVIRLI 470

  Fly   712 THNSVEERIMQVAKHKMMLTHLVVRPG---MGGMTTNFSKD-ELEDILRFGTEDLFKDGKSEAIH 772
            ..::|||.:.:.|..|:.||::::..|   :|........| :|.:||:||.:.|.   .||...
Human   471 GRDTVEEIVYRKAASKLQLTNMIIEGGHFTLGAQKPAADADLQLSEILKFGLDKLL---ASEGST 532

  Fly   773 YDDKAVADLLDRTNRGIEEKESWANEYLSSFKVASYATKEDHEEHDDYNNDAENTDPFYWENLMG 837
            .|:..:..:|..|..|     .|.::.|.    |:.....|.||..::        .:.:|   |
Human   533 MDEIDLESILGETKDG-----QWVSDALP----AAEGGSRDQEEGKNH--------MYLFE---G 577

  Fly   838 KSQPKLPKKQKKQSQQSQVD-----VESIMGKGKRIRKE 871
            |...|.|.|:.::|.:..|:     :|....:|:.:|.:
Human   578 KDYSKEPSKEDRKSFEQLVNLQKTLLEKASQEGRSLRNK 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CD_CSD	82..146	CDD:475127
		CD2_tandem_CHD3-4_like	176..230	CDD:349309
		PLN03142	266..>768	CDD:215601	218/512 (43%)
CHD1L	NP_004275.4	PLN03142	46..699	CDD:215601	241/621 (39%)
		DEAH box	174..177		2/2 (100%)
		Regulatory linker segment (RLS). /evidence=ECO:0000269|PubMed:33357431	601..635		3/16 (19%)
		Required for ATPase activity. /evidence=ECO:0000269|PubMed:29220653	615..673		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	628..654
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	687..711
		Macro_Poa1p-like_SNF2	716..866	CDD:394880