Protein Alignment Chd3 and ISW1

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: NP_009804.1
• Gene: ISW1 / 852547
• SGDID: S000000449
• Length: 1129
• Species: Saccharomyces cerevisiae
• Alignment Length: 735
• Identity: 267/735 - (36%)
• Similarity: 388/735 - (52%)
• Gaps: 139/735 - (18%)

  Fly   212 ERESDSIPGLNQAIALYKKLRSSNKGRQRDRPAPTIDLNKK---YEDQPVFLKE----------- 262
            |.::...|...|.:.:.::.:::.||:.:.:     |:.::   :|:....|||
Yeast   124 ESKAAKDPKFRQVLDVLEENKANGKGKGKHQ-----DVRRRKTEHEEDAELLKEEDSDDDESIEF 183

  Fly   263 --------AGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCR--- 316
                    ...:|.|:||:||:||.......|..|||||||||||:||:.||      |:.|
Yeast   184 QFRESPAYVNGQLRPYQIQGVNWLVSLHKNKIAGILADEMGLGKTLQTISFL------GYLRYIE 242

  Fly   317 ---GPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARA-VIRKHEISFEEVTTKTMRENQT 377
               ||||:..|.|||.||.||:..|.|::......|.|..|| :|:|..:..:
Yeast   243 KIPGPFLVIAPKSTLNNWLREINRWTPDVNAFILQGDKEERAELIQKKLLGCD------------ 295

  Fly   378 QYKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQ 442
               |:|::.|||.|..:.:.|..|:|..:::|||||:::.:|...::|.::....:||:||||||
Yeast   296 ---FDVVIASYEIIIREKSPLKKINWEYIIIDEAHRIKNEESMLSQVLREFTSRNRLLITGTPLQ 357

  Fly   443 NNLEELFHLLNFLSSGKFNDLQTFQAEFTDVSKEEQ----VKRLHEILEPHMLRRLKADVLKSMP 503
            |||.||:.|||||....|:|.|.|...|:..|.||.    ||:||.:|:|.:|||:|:||..|:.
Yeast   358 NNLHELWALLNFLLPDIFSDAQDFDDWFSSESTEEDQDKIVKQLHTVLQPFLLRRIKSDVETSLL 422

  Fly   504 PKSEFIVRVELSSMQKKFYKHILTKNFKALNQKGGGRVCS--LLNIMMDLRKCCNHPYLFPSAAE 566
            ||.|..:.|.:||||||:||.||.|:..|:|...|.:...  ||||||.|||||||||||..|
Yeast   423 PKKELNLYVGMSSMQKKWYKKILEKDLDAVNGSNGSKESKTRLLNIMMQLRKCCNHPYLFDGA-- 485

  Fly   567 EATISPSGLYEMSS-LTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYD 630
                .|...|.... |...:.||.:|.|:||:||.:..|||:||||:::|::||.:.....|:|.
Yeast   486 ----EPGPPYTTDEHLVYNAAKLQVLDKLLKKLKEEGSRVLIFSQMSRLLDILEDYCYFRNYEYC 546

  Fly   631 RIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSR 695
            |||||...:.|.:|||.:|.|.|:.|||||:||||||||||.:||.|:::||||||..|:||..|
Yeast   547 RIDGSTAHEDRIQAIDDYNAPDSKKFVFLLTTRAGGLGINLTSADVVVLYDSDWNPQADLQAMDR 611

  Fly   696 AHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTN----FSKDELEDILR 756
            |||:||||:|.::|.||.|||||:|::.|..|:.|..||::.....:...    .|||.|..:::
Yeast   612 AHRIGQKKQVKVFRLVTDNSVEEKILERATQKLRLDQLVIQQNRTSLKKKENKADSKDALLSMIQ 676

  Fly   757 FGTEDLFKDG---------------KSEAIHYDDKAVADLLDRTNR-----------GIEEKE-- 793
            .|..|:||.|               |.:.|..|:.    ||...|:           |:::.:
Yeast   677 HGAADVFKSGTSTGSAGTPEPGSGEKGDDIDLDEL----LLKSENKTKSLNAKYETLGLDDLQKF 737

  Fly   794 ------SWANEYLSSFK----------VASYATKEDHEEH---DDYNNDAENTDPFYWENLMGK- 838
                  .|..:   .||          :....||.:.:|:   |:|..|..||         |:
Yeast   738 NQDSAYEWNGQ---DFKKKIQRDIISPLLLNPTKRERKENYSIDNYYKDVLNT---------GRS 790

  Fly   839 ---SQPKLPKKQKKQSQQSQ 855
               |.|::||.....|.|.|
Yeast   791 STPSHPRMPKPHVFHSHQLQ 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CD_CSD	82..146	CDD:475127
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	3/17 (18%)
		PLN03142	266..>768	CDD:215601	231/534 (43%)
ISW1	NP_009804.1	PLN03142	108..1057	CDD:215601	267/735 (36%)