Protein Alignment Chd3 and IRC5

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: NP_116696.2
• Gene: IRC5 / 850599
• SGDID: S000001934
• Length: 853
• Species: Saccharomyces cerevisiae
• Alignment Length: 777
• Identity: 241/777 - (31%)
• Similarity: 361/777 - (46%)
• Gaps: 166/777 - (21%)

  Fly   138 ASMVASFQRRSDMEEPSL-EELDDQD--------GNLHERFYRYGIKPEWLLVQRVINHSEE-PN 192
            |.:|....:.:..|:.|| :||.:.|        ..|:| |.|.......::...:::.|.| .|
Yeast    97 AQVVDKLAKDTKSEQKSLDDELSEMDTKTVSLKLKKLNE-FVRQSQVYSSIIADTLLHRSNEVAN 160

  Fly   193 GGTMYLVKWRELSYNDSSWERESDSIPGLNQAIALYKKLRSSNKGRQRDRPAPTIDLNKKYEDQP 257
            ..|      ::.|.:|.. |..|.......::|..:.|.:..|:.......||.....|    ||
Yeast   161 ANT------KDNSNSDDE-EHSSKKRKTKKKSITDFFKKQKKNEDTTTQNGAPDDAAIK----QP 214

  Fly   258 VFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLIS 322
            ..||...||  |:|:||::||...:..|:..|||||||||||:|::..|..:: |...:||||::
Yeast   215 RLLKNCILK--PYQLEGLNWLITLYENGLNGILADEMGLGKTVQSIALLAFIY-EMDTKGPFLVT 276

  Fly   323 VPLSTLTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTS 387
            .|||||.||..|...:||:|..:.|.|..           .::|.:.|.....:......:::||
Yeast   277 APLSTLDNWMNEFAKFAPDLPVLKYYGTN-----------GYKERSAKLKNFFKQHGGTGIVITS 330

  Fly   388 YEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLL 452
            ||.|..|...:...:|..|:|||.|||::...:..:.|.|.....:||||||||||||.||:.||
Yeast   331 YEIILRDTDLIMSQNWKFLIVDEGHRLKNINCRLIKELKKINTSNRLLLTGTPLQNNLAELWSLL 395

  Fly   453 NFLSSGKFNDLQTFQAEF--------------------TDVSKEEQVKRLHEILEPHMLRRLKAD 497
            ||:....|.|.:.|...|                    .|..::..:..||.||:|.:|||||..
Yeast   396 NFIMPDIFADFEIFNKWFDFDSLNLGSGSNSEALNKLINDELQKNLISNLHTILKPFLLRRLKKV 460

  Fly   498 VLKS-MPPKSEFIVRVELSSMQKKFYK------------HILTKNFKALNQKGGGRVCS------ 543
            ||.: :|||.|:|:...::|.|:||||            ..|.|:|..||.:..|.|.:
Yeast   461 VLANILPPKREYIINCPMTSAQEKFYKAGLNGKLKKTMFKELIKDFFTLNDEYIGHVSNRSIRDF 525

  Fly   544 ----------------------------------------LLNIMMDLRKCCN------HPYLFP 562
                                                    |.|:||.||:..:      .|||.|
Yeast   526 INYKLSGNETSNTDNKINPTLLQMDKLYKKNLQMEISNKKLQNMMMQLRQIIDSTFLFYFPYLHP 590

  Fly   563 SAAEEATISPSGLYEMSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGY 627
               |:.|        :.:|.|.||||.:|.|::..|.::.|:||::||...||:::|.:.:...:
Yeast   591 ---EDLT--------LETLLKTSGKLQILQKLIPPLISEGHKVLIYSQFVNMLDLIEDWCDLNSF 644

  Fly   628 QYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQA 692
            ...|||||:..:.|:..:::||....:|.:|||||||.||||||..||||::|||||||..|:||
Yeast   645 ATFRIDGSVNNETRKDQLEKFNSSKDKHNIFLLSTRAAGLGINLVGADTVVLFDSDWNPQVDLQA 709

  Fly   693 FSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPG------------------- 738
            ..|.||:||:..|::||....|::|..|:..|.:|..|..:|::.|
Yeast   710 MDRCHRIGQESPVIVYRLCCDNTIEHVILTRAANKRNLERMVIQMGKFNNLKKLALNEGSFLKAN 774

  Fly   739 -MGGMTTNFSKD---ELEDILRFGTEDL-FKDG-----KSEAIHYDDKAVADLLDRTNRGIE 790
             .|...||  ||   ||..:|.....:: |::|     |:......||.|.:|   |||.:|
Yeast   775 KAGVNVTN--KDLVQELSMLLMSDESNIGFENGGQKENKATEGQLTDKEVEEL---TNRSLE 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CD_CSD	82..146	CDD:475127	2/7 (29%)
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	9/54 (17%)
		PLN03142	266..>768	CDD:215601	201/615 (33%)
IRC5	NP_116696.2	PLN03142	74..>767	CDD:215601	222/706 (31%)