Protein Alignment Chd3 and SMARCA5

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: NP_003592.3
• Gene: SMARCA5 / 8467
• HGNCID: 11101
• Length: 1052
• Species: Homo sapiens
• Alignment Length: 791
• Identity: 277/791 - (35%)
• Similarity: 405/791 - (51%)
• Gaps: 112/791 - (14%)

  Fly   129 PEGQMLLHHASMVASFQRRSDMEE------PSLE-ELDDQDGNLHE-----RFYRYGIKPEWLLV 181
            |||......||..::....::|||      |..: |:.:.|....|     |..|:    |:||.
Human    37 PEGVAAQAVASAASAGPADAEMEEIFDDASPGKQKEIQEPDPTYEEKMQTDRANRF----EYLLK 97

  Fly   182 Q-RVINHSEEP------------NGGTMYLVKWRELS------YNDSSWERESDSIPGLNQAIAL 227
            | .:..|..:|            ..|...:.|..:.:      |.....|:|.|.
Human    98 QTELFAHFIQPAAQKTPTSPLKMKPGRPRIKKDEKQNLLSVGDYRHRRTEQEEDE---------- 152

  Fly   228 YKKLRSSNKGRQRDRPAPTIDLNKKYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILAD 292
             :.|..|:|         ..::..::||.|.::|..  ||..:|:.|::||...:..||..||||
Human   153 -ELLTESSK---------ATNVCTRFEDSPSYVKWG--KLRDYQVRGLNWLISLYENGINGILAD 205

  Fly   293 EMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARAVI 357
            |||||||:||:..|..:....:..||.::.||.|||.||..|.:.|.|.|..|..:|.|..||..
Human   206 EMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRSVCLIGDKEQRAAF 270

  Fly   358 RKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFF 422
                          :|:.....:::|.:||||.:..:.:.....:|..||:|||||:::.:||..
Human   271 --------------VRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLS 321

  Fly   423 RILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTD---VSKEEQVKRLHE 484
            .|:.:::...:||||||||||||.||:.|||||....||....|.:.|..   :..::.|:|||.
Human   322 EIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWFDTNNCLGDQKLVERLHM 386

  Fly   485 ILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTKNFKALNQKGGGRVCSLLNIMM 549
            :|.|.:|||:||||.||:|||.|..:.|.||.||:::|..||.|:...||..|......||||:|
Human   387 VLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSAGKMDKMRLLNILM 451

  Fly   550 DLRKCCNHPYLFPSAAEEATISPSGLYEMSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKM 614
            .|||||||||||..|..    .|....:|..:|. |||:.:|.|:|.:||....|||:|||||::
Human   452 QLRKCCNHPYLFDGAEP----GPPYTTDMHLVTN-SGKMVVLDKLLPKLKEQGSRVLIFSQMTRV 511

  Fly   615 LNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVII 679
            |::||.:.....|:|.|:||....|.||.:|:.:|:|.|..|||:||||||||||||||||.||:
Human   512 LDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGINLATADVVIL 576

  Fly   680 FDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPG--MGGM 742
            :||||||..|:||..||||:||.|.|.::||:|.|:|||||::.|:.|:.|..:|::.|  :...
Human   577 YDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQN 641

  Fly   743 TTNFSKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRTNRGIEEKESWANEYLSSFKVAS 807
            .....|||:..::|.|...:|...:||   ..|:.:..:|:|.    .:|.:..||.||....:|
Human   642 LNKIGKDEMLQMIRHGATHVFASKESE---ITDEDIDGILERG----AKKTAEMNEKLSKMGESS 699

  Fly   808 YATKEDHEEHDDYNNDAEN------------TDP------------FYWENLMGKSQPKLPKKQK 848
            ........|...||.:.|:            .:|            .|:...:..|:||.||..:
Human   700 LRNFTMDTESSVYNFEGEDYREKQKIAFTEWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPR 764

  Fly   849 KQSQQSQVDVE 859
            ...|.:..|.:
Human   765 PPKQPNVQDFQ 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CD_CSD	82..146	CDD:475127	5/16 (31%)
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	12/72 (17%)
		PLN03142	266..>768	CDD:215601	220/506 (43%)
SMARCA5	NP_003592.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83		11/45 (24%)
		PLN03142	69..1012	CDD:215601	268/759 (35%)
		DEAH box	308..311		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1052