DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and CHD6

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_016883588.1	Gene:	CHD6 / 84181	HGNCID:	19057	Length:	2716	Species:	Homo sapiens

Alignment Length:	914	Identity:	317/914 - (34%)
Similarity:	483/914 - (52%)	Gaps:	121/914 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PDWKTPGKASKDKRPKTNAKKQKFRDEEYCKVCSDGGDLLCCDSC--PSVYHRTCLSPPLKSIPK 71
            |:..|....|:.:|.....|::|:.::...||..|.|:.:.....  .|....:.|:...:..|:
Human   225 PEESTESTDSQKRRSGRQVKRRKYNEDLDFKVVDDDGETIAVLGAGRTSALSASTLAWQAEEPPE 289

  Fly    72 GDWICPRCIPLPGKAEKILSWRWALDRSVELRTSKGEKRRE---YFIKWHGMSYWHCEWIPEGQM 133
            .|         ....||||:     .::|: ....||...:   :::|:...||.||:|
Human   290 DD---------ANIIEKILA-----SKTVQ-EVHPGEPPFDLELFYVKYRNFSYLHCKW------ 333

  Fly   134 LLHHASMVASFQRRSDMEEPSLEELDDQDGNLHERFYRYGIK-----------------PEWLLV 181
                               .::||| ::|..:.::..|:..|                 |:::.|
Human   334 -------------------ATMEEL-EKDPRIAQKIKRFRNKQAQMKHIFTEPDEDLFNPDYVEV 378

  Fly   182 QRVIN--HSEEPNGG---TMYLVKWRELSYNDSSWERESDSIPGLNQAIALYKKLRSSNKGRQRD 241
            .|::.  |:::...|   |.|||||..|.|.:|:||.|.|..|.   .:..::.|:...:.:..:
Human   379 DRILEVAHTKDAETGEEVTHYLVKWCSLPYEESTWELEEDVDPA---KVKEFESLQVLPEIKHVE 440

  Fly   242 RPA----PTIDLNKKYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQT 302
            |||    ..::.:::|::..        :|..:|:||::||.::|......|||||||||||||:
Human   441 RPASDSWQKLEKSREYKNSN--------QLREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQS 497

  Fly   303 VVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEV 367
            :.||..:|..| ..|||||..||||:||||||...|. |:..:.|.|.:.:|.:|:::|:.:.:.
Human   498 ITFLSEIFLRG-IHGPFLIIAPLSTITNWEREFRTWT-EMNAIVYHGSQISRQMIQQYEMVYRDA 560

  Fly   368 TTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGY 432
            ....:   ...:||:|::|::|.|..|...|..|.|:.:::||||||::...|....|....:.:
Human   561 QGNPL---SGVFKFHVVITTFEMILADCPELKKIHWSCVIIDEAHRLKNRNCKLLEGLKLMALEH 622

  Fly   433 KLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKAD 497
            |:|||||||||::||||.|||||...:|.....|..||.|:..|||||:|..||:|.||||||.|
Human   623 KVLLTGTPLQNSVEELFSLLNFLEPSQFPSETAFLEEFGDLKTEEQVKKLQSILKPMMLRRLKDD 687

  Fly   498 VLKSMPPKSEFIVRVELSSMQKKFYKHILTKNFKALNQKGGGR--VCSLLNIMMDLRKCCNHPYL 560
            |.|::.||.|.|:.|||:::|||:|:.||.|||..|. ||..:  :.:|:|.||:||||||||||
Human   688 VEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLT-KGANQHNMPNLINTMMELRKCCNHPYL 751

  Fly   561 FPSAAEE------ATISPSGL-YEMSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVL 618
            ...|.|:      .|.||... :::.::.:|:|||.|:.|:|.:|.|..|:||:||||.:.|::|
Human   752 INGAEEKILEDFRKTHSPDAPDFQLQAMIQAAGKLVLIDKLLPKLIAGGHKVLIFSQMVRCLDIL 816

  Fly   619 EHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSD 683
            |.:|....|.|:||||.::|:|||.|||||..|.|:.|||||.||||||||||..|||.||||||
Human   817 EDYLIQRRYTYERIDGRVRGNLRQAAIDRFCKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSD 881

  Fly   684 WNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVV----RPGMGGMTT 744
            |||.||:||.:|.||:||.|.|.:||.:|.||.|..:...|..|:.|...|:    |.|......
Human   882 WNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQDINRKGGTNGVQ 946

  Fly   745 NFSKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRTNRGIEEKESWANEYLSSFKVASYA 809
            ..||.|:||:||.|......|.:.|...:.::.:..:|.|....|..:.....   |:|..||:.
Human   947 QLSKMEVEDLLRKGAYGALMDEEDEGSKFCEEDIDQILQRRTHTITIQSEGKG---STFAKASFV 1008

  Fly   810 TKEDHEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQKKQSQQSQVDVESIMGKGKRIRKEIDY 874
            ...:       ..|....||.:|:.....::.....|.:|         ||::....|:||:..:
Human  1009 ASGN-------RTDISLDDPNFWQKWAKIAELDTEAKNEK---------ESLVIDRPRVRKQTKH 1057

  Fly   875 SNQY 878
            .|.:
Human  1058 YNSF 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	8/43 (19%)
		CHROMO	85..147	CDD:237991	13/64 (20%)
		CHROMO	181..233	CDD:214605	19/56 (34%)
		SNF2_N	270..561	CDD:278600	137/292 (47%)
		DEXDc	288..440	CDD:238005	62/151 (41%)
		Helicase_C	585..700	CDD:278689	70/114 (61%)
CHD6	XP_016883588.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910