DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and PKR2

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_194918.2	Gene:	PKR2 / 829320	AraportID:	AT4G31900	Length:	1202	Species:	Arabidopsis thaliana

Alignment Length:	872	Identity:	347/872 - (39%)
Similarity:	489/872 - (56%)	Gaps:	138/872 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 PKGDWI----------------------CPRCIPLPGKAEKILSWRWALDRSVELRTSKGEKR-- 110
            ||.|:|                      ||.     |:.||||...|....|....:|.....
plant    14 PKPDYIEDKLDEYIREEQVEETGGSNQDCPL-----GEIEKILDREWRPTASNNPNSSDNGTPTL 73

  Fly   111 ---REYFIKWHGMSYWHCEWIPEGQMLLHHAS--------MVASFQRRSDMEEPSLEELDDQDGN 164
               ::|.:||.|:||.||.|:||.:....:.|        .|..|....|        :...:..
plant    74 VVVKQYLVKWKGLSYLHCSWVPEQEFEKAYKSHPHLKLKLRVTRFNAAMD--------VFIAENG 130

  Fly   165 LHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELSYNDSSWERESDSIPGLNQAIALYK 229
            .||..   .|:|||..|.|:| ...|.:.|..||||::||||.:|.||.||| |......|..:|
plant   131 AHEFI---AIRPEWKTVDRII-ACREGDDGEEYLVKYKELSYRNSYWESESD-ISDFQNEIQRFK 190

  Fly   230 KLRSSNK-----GRQRDRPAPTIDLNKKYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTI 289
            .:.||::     ..:|:|     :..|:::..|.||...   ||.:|:||:::|||||.:....|
plant   191 DINSSSRRDKYVENERNR-----EEFKQFDLTPEFLTGT---LHTYQLEGLNFLRYSWSKKTNVI 247

  Fly   290 LADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTAR 354
            ||||||||||||::.||.|||:|.  ..|.|:..||||:.|||||...|||.:..|.|.|...||
plant   248 LADEMGLGKTIQSIAFLASLFEEN--LSPHLVVAPLSTIRNWEREFATWAPHMNVVMYTGDSEAR 310

  Fly   355 AVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQS 419
            .||.:||..|.|         ..:.||:|:||:||.:....:.|..|.|..:::||.|||::.:|
plant   311 DVIWEHEFYFSE---------GRKSKFDVLLTTYEMVHPGISVLSPIKWTCMIIDEGHRLKNQKS 366

  Fly   420 KFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTDVSKEEQVKRLHE 484
            |.:..||::...:.:|||||||||||.|||.|::||.:.||..|:.||    |::||||:.|||:
plant   367 KLYSSLSQFTSKHIVLLTGTPLQNNLNELFALMHFLDADKFGSLEKFQ----DINKEEQISRLHQ 427

  Fly   485 ILEPHMLRRLKADVLK-SMPPKSEFIVRVELSSMQKKFYKHILTKNFKALNQKGGGRVCSLLNIM 548
            :|.||:|||||.|||| .:|||.|.|:||::||.||:.||.::|.|::.|.:|   |...:.|::
plant   428 MLAPHLLRRLKKDVLKDKVPPKKELILRVDMSSQQKEVYKAVITNNYQVLTKK---RDAKISNVL 489

  Fly   549 MDLRKCCNHPYLFP------SAAEEATISPSGLYEMSSLTKASGKLDLLSKMLKQLKADNHRVLL 607
            |.||:.|:||||.|      ..|.||         .:.|.:|||||.||.||:.:||...||||:
plant   490 MKLRQVCSHPYLLPDFEPRFEDANEA---------FTKLLEASGKLQLLDKMMVKLKEQGHRVLI 545

  Fly   608 FSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLA 672
            ::|....|.:||.:...:.:.|:||||.|.|..||..|||||...|..|.|||||||||:|||||
plant   546 YTQFQHTLYLLEDYFTFKNWNYERIDGKISGPERQVRIDRFNAENSNRFCFLLSTRAGGIGINLA 610

  Fly   673 TADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRP 737
            |||||||:|||||||.|:||.:|.||:||..||||||.:...:||||:|::.|:||:|.||||.
plant   611 TADTVIIYDSDWNPHADLQAMARVHRLGQTNKVMIYRLIHKGTVEERMMEITKNKMLLEHLVVG- 674

  Fly   738 GMGGMTTNFSKDELEDILRFGTEDLFKD-----GKSEAIHYDDKAVADLLDRTN-----RGIEEK 792
                 ..:..:|||:||:::|:::||.:     |:|..|||||.|:..||||.:     ..::::
plant   675 -----KQHLCQDELDDIIKYGSKELFSEENDEAGRSGKIHYDDAAIEQLLDRNHVDAVEVSLDDE 734

  Fly   793 ESWANEYLSSFKVASYATKEDHEEHD--------DYNNDAENTD-PFYWENLMGKSQPKLPKKQK 848
            |.  .::|.:|||||:...:|..|..        :.|:...|.| ..:|::|:         |.|
plant   735 EE--TDFLKNFKVASFEYVDDENEAAALEEAQAIENNSSVRNADRTSHWKDLL---------KDK 788

  Fly   849 KQSQQSQVDVESIMGKGKRIRKEIDYS 875
            .:.||:  :..|.:||.||..|::.|:
plant   789 YEVQQA--EELSALGKRKRNGKQVMYA 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	6/30 (20%)
		CHROMO	85..147	CDD:237991	21/74 (28%)
		CHROMO	181..233	CDD:214605	22/51 (43%)
		SNF2_N	270..561	CDD:278600	139/291 (48%)
		DEXDc	288..440	CDD:238005	67/151 (44%)
		Helicase_C	585..700	CDD:278689	68/114 (60%)
PKR2	NP_194918.2	CHROMO	46..112	CDD:237991	19/65 (29%)
		CHROMO	140..191	CDD:214605	23/52 (44%)
		SNF2_N	228..502	CDD:278600	139/291 (48%)
		DEXDc	245..387	CDD:238005	67/152 (44%)
		Helicase_C	523..638	CDD:278689	68/114 (60%)
		DUF1087	<774..816	CDD:283996	15/51 (29%)
		DUF1086	855..999	CDD:283992
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	296	1.000	Domainoid score	I346
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D54215at2759
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	1	1.000	-	-		mtm1191
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780