Protein Alignment Chd3 and CHD9

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: XP_005256225.1
• Gene: CHD9 / 80205
• HGNCID: 25701
• Length: 2898
• Species: Homo sapiens
• Alignment Length: 856
• Identity: 327/856 - (38%)
• Similarity: 472/856 - (55%)
• Gaps: 137/856 - (16%)

  Fly    81 PLPGK-----------------AEKILSWRWALDRSVELRTSKGE--KRREYFIKWHGMSYWHCE 126
            ||||:                 .:||||     .|:|:...|.|.  ...|:|:|:...||.|||
Human   670 PLPGEQPLQLFVENPSEEDAAIVDKILS-----SRTVKKEISPGVMIDTEEFFVKYKNYSYLHCE 729

  Fly   127 WIPEGQML-------------LHHASMVASFQRRSDMEEPSLEELDDQDGNLHERFYRYGIKPEW 178
            |..|.|:|             |..|.....|   :||||              |.|     .|::
Human   730 WATEEQLLKDKRIQQKIKRFKLRQAQRAHFF---ADMEE--------------EPF-----NPDY 772

  Fly   179 LLVQRVINHS--EEPNGG---TMYLVKWRELSYNDSSWERESDSIPGLNQA-IALYKKLRSSNKG 237
            :.|.||:..|  |:.:.|   ..|||||..|.|.||:||.:.|    ::.| |..:::|::|...
Human   773 VEVDRVLEVSFCEDKDTGEPVIYYLVKWCSLPYEDSTWELKED----VDLAKIEEFEQLQASRPD 833

  Fly   238 RQR-DRPAPT----IDLNKKYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLG 297
            .:| |||...    ||.::.|::        |.:|..:|:||::||.::|......|||||||||
Human   834 TRRLDRPPSNIWKKIDQSRDYKN--------GNQLREYQLEGLNWLLFNWYNRRNCILADEMGLG 890

  Fly   298 KTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARAVIRKHEI 362
            ||||::.|||.:...| .||||||..||||:.|||||...|. ::..|.|.|...:|.:|:::|:
Human   891 KTIQSITFLYEILLTG-IRGPFLIIAPLSTIANWEREFRTWT-DINVVVYHGSLISRQMIQQYEM 953

  Fly   363 SFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSK 427
            .|.:...:.:|   ..|:|..::|::|.|......|..|:|..:::||||||::...|....|..
Human   954 YFRDSQGRIIR---GAYRFQAIITTFEMILGGCGELNAIEWRCVIIDEAHRLKNKNCKLLEGLKL 1015

  Fly   428 YRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLR 492
            ..:.:|:|||||||||.:||||.||:||...:|....||..||.|:..||||::|..||:|.|||
Human  1016 MNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKTEEQVQKLQAILKPMMLR 1080

  Fly   493 RLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTKNFKALNQKGGGR--VCSLLNIMMDLRKCC 555
            |||.||.|.:.||.|.|:.|||:::|||:|:.||.|||..|: ||.|:  |.:|:|.||:|||||
Human  1081 RLKEDVEKKLAPKEETIIEVELTNIQKKYYRAILEKNFSFLS-KGAGQTNVPNLVNTMMELRKCC 1144

  Fly   556 NHPYLFPSAAEEA------TISPSGL-YEMSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTK 613
            |||||...|.|:.      |.:|:.. :.:.::.:::|||.|:.|:|.::||..|:||:||||.:
Human  1145 NHPYLIKGAEEKILGEFRDTYNPAASDFHLQAMIQSAGKLVLIDKLLPKMKAGGHKVLIFSQMVR 1209

  Fly   614 MLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVI 678
            .|::||.:|..:.|.|:||||.::|:|||.|||||:.|.|:.|||||.||||||||||..|||.|
Human  1210 CLDILEDYLIHKRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCI 1274

  Fly   679 IFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMT 743
            ||||||||.||:||.:|.||:||.|.|.:||.||.||.|..:...|..|:.|...|:: .|.|..
Human  1275 IFDSDWNPQNDLQAQARCHRIGQNKAVKVYRLVTRNSYEREMFDRASLKLGLDKAVLQ-SMSGRE 1338

  Fly   744 TN------FSKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRTNRGIE-EKESWANEYLS 801
            :|      .||.|:||:||.|......:.:.|...:.::.:..:|.|..:.|. |.|...    |
Human  1339 SNVGGIQQLSKKEIEDLLRRGAYGAIMEEEDEGSKFCEEDIDQILLRRTKTITIESEGRG----S 1399

  Fly   802 SFKVASYATKEDHEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQKKQSQQSQVDVESIMGKGK 866
            :|..||:....:       ..|....||.:|:               |.::::::|:|:|.|:..
Human  1400 TFAKASFVASGN-------RTDISLDDPNFWQ---------------KWAKKAEIDIEAISGRNS 1442

  Fly   867 ------RIRKE 871
                  ||||:
Human  1443 LVIDTPRIRKQ 1453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CD_CSD	82..146	CDD:475127	26/95 (27%)
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	21/59 (36%)
		PLN03142	266..>768	CDD:215601	240/516 (47%)
CHD9	XP_005256225.1	GAT1	161..558	CDD:227928
		ROM1	176..>362	CDD:227709
		CD1_tandem_CHD5-9_like	686..750	CDD:349315	20/68 (29%)
		CD2_tandem_CHD5-9_like	770..828	CDD:349310	21/61 (34%)
		PLN03142	811..>1480	CDD:215601	277/688 (40%)
		BRK	2483..2532	CDD:197800
		BRK	2557..2601	CDD:197800