Protein Alignment Chd3 and smarcal1

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: NP_001072923.1
• Gene: smarcal1 / 780385
• XenbaseID: XB-GENE-493391
• Length: 942
• Species: Xenopus tropicalis
• Alignment Length: 754
• Identity: 161/754 - (21%)
• Similarity: 278/754 - (36%)
• Gaps: 246/754 - (32%)

  Fly   137 HASMVASFQRRSDMEEPSLEELDDQDGNLHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKW 201
            :||:::..|:...:|..:||.::             |::         |.......|||    ..
 Frog   280 YASLMSEVQQLQSVELKALEGME-------------GVQ---------IAPPPATGGGT----NI 318

  Fly   202 RELSYNDSSWERESDSIPGL----------------NQAIALYKKLRSSN---KGRQ-------- 239
            ..|....::|:|.|.::.|.                .:.|.|:|::.:.|   |.|:
 Frog   319 NALLAMCNNWQRPSATLRGRCILVSRSRFEMEIGYHAEIIGLFKQMNTRNYDTKTRKWSFMLEDY 383

  Fly   240 ---------------RDRPAPTIDLNKKYEDQPVFLKE-------------AGLKLHPFQIEGVS 276
                           ...|.|.:........:...::|             .|..|.|||.:||:
 Frog   384 QKLMESVRNIQQVEVEPLPRPVLQAFAPQFGKTTIIREEIPEVDLSQVDSKLGSNLMPFQRDGVN 448

  Fly   277 WLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPE 341
            :.....|:   .:|||:||||||||.:.......||    .|.|:..|.|....|....:.|.|.
 Frog   449 FAVSREGR---LLLADDMGLGKTIQAICIAAYYRKE----WPLLVVAPSSVRFTWAEAFQRWLPS 506

  Fly   342 LYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCID---- 402
                           ||...::    ...|.|::|:....|:       :|.|  .||.:|
 Frog   507 ---------------IRPESVN----VIVTGRDSQSASLINI-------VSFD--LLGKMDKQIA 543

  Fly   403 --WAALVVDEAHRLRSNQSKFFR-----ILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKF 460
              :..:::||:|.|::.::...:     :.|..|:   :||:|||..:...||:..:..:....|
 Frog   544 ATFQVIIIDESHFLKNVKTARCKAAMPLLKSAKRV---MLLSGTPAMSRPAELYTQIAAVRPSFF 605

  Fly   461 NDLQTFQAEFTDV------------SKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIV--- 510
            .....|...:.|.            |...::|.|.|  |..|:||||::||..:|.|...:|
 Frog   606 PRFHDFGIRYCDAKQMPWGWDYSGSSNLNELKLLLE--ESIMIRRLKSEVLSQLPAKQRKMVVVA 668

  Fly   511 --------RVELSSMQKKFYKHILTKNFKA-----------LNQKGGGRVCSLLNIMMDLRKCCN 556
                    :..|::..|:     :.|.||:           .|:....::.|:|..:|||
 Frog   669 PEGITAKTKAALAAAAKE-----MAKGFKSKVQEKEALLLFYNRTAEAKIRSVLEYIMDL----- 723

  Fly   557 HPYLFPSAAEEATISPSGLYEMSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHF 621
                                                     |::...:.|:|:. .|:  ||:|.
 Frog   724 -----------------------------------------LESGREKFLVFAH-HKL--VLDHI 744

  Fly   622 LEGEGYQ---YDRIDGSIKGDLRQKAIDRFNDPVSE-HFVFLLSTRAGGLGINLATADTVIIFDS 682
            .|..|.:   |.||||:.....||....:|.  :|| ..|.:||..|..:|:.|::||.|:..:.
 Frog   745 CEELGKKDVPYIRIDGNTSSADRQSLCHKFQ--MSEKSCVAVLSITAANMGLTLSSADLVVFAEL 807

  Fly   683 DWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMT-TNF 746
            .|||...:||..|.||:||...|.|:..|...:.::.:..:.:.|:.:.      |..|:: .||
 Frog   808 FWNPGVLIQAEDRVHRIGQTSSVNIHYLVAKGTADDYLWPMIQEKIKVL------GQAGLSEANF 866

  Fly   747 SKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRT 785
            |:      ....|:..:||.|.:.|:       ||..|:
 Frog   867 SE------TTESTDYFYKDPKQKTIY-------DLFQRS 892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CD_CSD	82..146	CDD:475127	2/8 (25%)
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	11/69 (16%)
		PLN03142	266..>768	CDD:215601	130/551 (24%)
smarcal1	NP_001072923.1	PTZ00436	<7..205	CDD:185616
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..214
		HARP	244..298	CDD:462166	4/17 (24%)
		HARP	347..401	CDD:462166	6/53 (11%)
		DEXHc_HARP_SMARCAL1	439..648	CDD:350768	60/248 (24%)
		DESH box	552..555		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9NZC9	647..664		8/16 (50%)
		SF2_C_SNF	711..836	CDD:350180	45/175 (26%)