DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and Chd5

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_017449128.1	Gene:	Chd5 / 691589	RGDID:	1582725	Length:	2000	Species:	Rattus norvegicus

Alignment Length:	994	Identity:	511/994 - (51%)
Similarity:	658/994 - (66%)	Gaps:	136/994 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DPD--------WKTP----------GKASKDKRPKTNAKKQKFRDEEYCKVCSDGGDLLCCDSCP 54
            ||:        |..|          .|...::..:...::::....|:|:||.|||:|||||:||
  Rat   369 DPELEKAPEGKWSCPHCEKEGIQWEPKDDDEEEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACP 433

  Fly    55 SVYHRTCLSPPLKSIPKGDWICPRCI--PLPGKAEKILSWRWALDRSVEL--------------- 102
            |.||..||:|||..||.|:|:||||.  ||.||.::||.|||....:..:
  Rat   434 SSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFMVGLPGPEVEPGMPPP 498

  Fly   103 RTSKGEKRREYFIKWHGMSYWHCEWIPEGQMLLHHASMVASFQRRSDMEEPSLEEL--DDQDG-- 163
            |..:|...||:|:||.|:|||||.|:.|.|:.|:|..|..::||::||:||...:.  .|:||
  Rat   499 RPLEGIPEREFFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGKS 563

  Fly   164 -----------NLHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELSYNDSSWERESDS 217
                       .:.||||||||||||::|.|::|||.:..|...||:||::|.|:..:||.:...
  Rat   564 EKRKNKDPLYAKMEERFYRYGIKPEWMMVHRILNHSFDKKGDVHYLIKWKDLPYDQCTWEIDEID 628

  Fly   218 IP---GLNQAIALYKKL----------RSSNKGR-----QRDRP--APTIDLNKKYEDQPVFLKE 262
            ||   .|.|....:::|          |...||:     ::::|  .|.:|...|::.||.::..
  Rat   629 IPYYDNLKQTYWGHRELMLGEDARLPKRLVKKGKKLKDDKQEKPPDTPIVDPTVKFDKQPWYIDS 693

  Fly   263 AGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLST 327
            .|..|||:|:||::|||:||.||..||||||||||||:||:||||||:||||.:||:|:|.||||
  Rat   694 TGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLST 758

  Fly   328 LTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVT----TKTMR-ENQTQYKFNVMLTS 387
            :.|||||.|:|||:.|.|||.|.|.:|:|||::|.|||:..    .|..| :.:.|.||:|:|||
  Rat   759 IINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRGGKKVFRMKKEVQIKFHVLLTS 823

  Fly   388 YEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLL 452
            ||.|::|.|.||.|:||.|||||||||::|||||||:|:.|:|.|||||||||||||||||||||
  Rat   824 YELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLL 888

  Fly   453 NFLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSM 517
            |||:..:||:|:.|..||.|:|||:|:|:||::|.|||||||||||.|:||.|:|.|||||||.|
  Rat   889 NFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQM 953

  Fly   518 QKKFYKHILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYEMSSLT 582
            |||:||.|||:||:|||.||||...|||||||||:||||||||||.||.||.:.|:|.|:.|||.
  Rat   954 QKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPMLPNGSYDGSSLV 1018

  Fly   583 KASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDR 647
            |:||||.||.||||:|:.:.||||:||||||||::||.|||.|||:|:||||.|.|.|||:||||
  Rat  1019 KSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDR 1083

  Fly   648 FNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVT 712
            ||.|.::.|.||||||||||||||||||||||:|||||||||:||||||||:||.||||||||||
  Rat  1084 FNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVT 1148

  Fly   713 HNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDELEDILRFGTEDLFKDG----------- 766
            ..||||||.||||.||||||||||||:|..:.:.:|.||:|||:||||:||||.
  Rat  1149 RASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVEGMMSQGQRP 1213

  Fly   767 -----------------------------------KSEAIHYDDKAVADLLDRTNRGIEEKE-SW 795
                                               .|..|||||.|::.||||.....::.| ..
  Rat  1214 TTPIPDVQSTKGGSLAAGAKKKHGGTPPGDNKDVEDSSVIHYDDAAISKLLDRNQDATDDTELQN 1278

  Fly   796 ANEYLSSFKVASYATKED---HEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQKKQSQQSQVD 857
            .||||||||||.|..:|:   .|...:.....||.||.|||.|:           :...:|.|.|
  Rat  1279 MNEYLSSFKVAQYVVREEDGVEEVEREVIKQEENVDPDYWEKLL-----------RHHYEQQQED 1332

  Fly   858 VESIMGKGKRIRKEIDYSN 876
            :...:||||||||:::|::
  Rat  1333 LARNLGKGKRIRKQVNYND 1351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	27/41 (66%)
		CHROMO	85..147	CDD:237991	26/76 (34%)
		CHROMO	181..233	CDD:214605	19/64 (30%)
		SNF2_N	270..561	CDD:278600	199/295 (67%)
		DEXDc	288..440	CDD:238005	100/156 (64%)
		Helicase_C	585..700	CDD:278689	88/114 (77%)
Chd5	XP_017449128.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	145	1.000	Domainoid score	I4455
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35578at33208
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	1	1.000	-	-		otm45407
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.780