Protein Alignment Chd3 and HLTF

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: XP_011511393.1
• Gene: HLTF / 6596
• HGNCID: 11099
• Length: 1013
• Species: Homo sapiens
• Alignment Length: 821
• Identity: 184/821 - (22%)
• Similarity: 303/821 - (36%)
• Gaps: 246/821 - (29%)

  Fly    81 PLPGKAEKILSWRWALDRSVELRTSKGEKRREYFIKWHGMSYWHCEWIPEGQMLLHHASMVASFQ 145
            ||....::.|:|..:.:.|.||.....::...|:                        :.:.:|.
Human   239 PLLPHQKQALAWMVSRENSKELPPFWEQRNDLYY------------------------NTITNFS 279

  Fly   146 RRSDMEEPSLEELDDQDG-------------NLH-------ERFYRYGIKPEWLLVQRVINHSEE 190
            .:...|......|.|..|             |.|       ||..:..:|.|:     .:|....
Human   280 EKDRPENVHGGILADDMGLGKTLTAIAVILTNFHDGRPLPIERVKKNLLKKEY-----NVNDDSM 339

  Fly   191 PNGGTMYLVKWRELSYNDSSWERESDSIPGLNQAIALYKKLRSSNKGRQRDRPAPTIDL--NKKY 253
            ..||.....|...|| .|:|...|..||..:.:.........||::.::|......|:.  :::.
Human   340 KLGGNNTSEKADGLS-KDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIESSDSEEI 403

  Fly   254 EDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSL--------- 309
            |...:..|..| ||...|.|       :.|:.       :.|..|.|:.|.|..:|
Human   404 ETSELPQKMKG-KLKNVQSE-------TKGRA-------KAGSSKVIEDVAFACALTSSVPTTKK 453

  Fly   310 --FKEGHCR-------------GPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARAVIRK 359
              .|:|.|.             ...||..|||.|:||..:.              |:..::.:
Human   454 KMLKKGACAVEGSKKTDVEERPRTTLIICPLSVLSNWIDQF--------------GQHIKSDV-- 502

  Fly   360 HEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLG-----CIDWAALVVDEAHRLR---S 416
            |...:.......:||.....|.:::||:|..::.|....|     .|.|..:::||.|.:|   :
Human   503 HLNFYVYYGPDRIREPALLSKQDIVLTTYNILTHDYGTKGDSPLHSIRWLRVILDEGHAIRNPNA 567

  Fly   417 NQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQ----TFQAEFTDVSKEE 477
            .|:|....|...|   :.:|||||:||:|::|:.||:||....|.|.:    |.|...| :..|.
Human   568 QQTKAVLDLESER---RWVLTGTPIQNSLKDLWSLLSFLKLKPFIDREWWHRTIQRPVT-MGDEG 628

  Fly   478 QVKRLHEILEPHMLRRLKADVLK-----SMPPKSEFIVRVELSSMQKKFYKHILTKNFKALNQKG 537
            .::||..:::...|||.|...:|     .:|.:..||..:.||..::|.|:.:          |.
Human   629 GLRRLQSLIKNITLRRTKTSKIKGKPVLELPERKVFIQHITLSDEERKIYQSV----------KN 683

  Fly   538 GGRV---------------CSLLNIMMDLRKCCNHPYLF--------PSAAEEATISPSGLYE-- 577
            .||.               ..:|.:::.||:.|.|.||.        |||......:|..|.:
Human   684 EGRATIGRYFNEGTVLAHYADVLGLLLRLRQICCHTYLLTNAVSSNGPSAFSLGNDTPEELRKKL 748

  Fly   578 -------------------MSSLT----------------------------------------- 582
                               :.|||
Human   749 IRKMKLILSSGSDEECAICLDSLTVPVITHCAHVFCKPCICQVIQNEQPHAKCPLCRNDIHEDNL 813

  Fly   583 --------------------KASGKLDLLSKMLKQLKADNHRV--LLFSQMTKMLNVLEHFLEGE 625
                                .:|.|::.|...|..|:..|..:  |:.||.|..|:::|..|:..
Human   814 LECPPEELARDSEKKSDMEWTSSSKINALMHALTDLRKKNPNIKSLVVSQFTTFLSLIEIPLKAS 878

  Fly   626 GYQYDRIDGSIKGDLRQKAIDRF-NDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHND 689
            |:.:.|:|||:....|.::|..| |.......:.|||.:|||:|:||:.|..|.:.|..|||..:
Human   879 GFVFTRLDGSMAQKKRVESIQCFQNTEAGSPTIMLLSLKAGGVGLNLSAASRVFLMDPAWNPAAE 943

  Fly   690 VQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMML 730
            .|.|.|.||:|||::|:|.:|:..:||||.::::...|..|
Human   944 DQCFDRCHRLGQKQEVIITKFIVKDSVEENMLKIQNKKREL 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CD_CSD	82..146	CDD:475127	8/63 (13%)
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	12/53 (23%)
		PLN03142	266..>768	CDD:215601	147/614 (24%)
HLTF	XP_011511393.1	HIRAN	60..153	CDD:400928
		DEXHc_HLTF1_SMARC3	240..644	CDD:350829	100/468 (21%)
		DEAD-like_helicase_N	283..>357	CDD:475120	16/79 (20%)
		HepA	<472..990	CDD:440319	133/543 (24%)
		RING-HC_HLTF	759..813	CDD:438172	3/53 (6%)