DRSC/TRiP Functional Genomics Resources

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Protein Alignment Chd3 and SMARCA2

DIOPT Version :10

Sequence 1:NP_649111.1 Gene:Chd3 / 40111 FlyBaseID:FBgn0023395 Length:892 Species:Drosophila melanogaster
Sequence 2:NP_003061.3 Gene:SMARCA2 / 6595 HGNCID:11098 Length:1590 Species:Homo sapiens


Alignment Length:778 Identity:264/778 - (33%)
Similarity:402/778 - (51%) Gaps:139/778 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   147 RSDMEE--PSLEELDDQDGNLHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELSYNDS 209
            |||.||  ...||.|:::.:..:.      ..|.:|:        :||.        .|:|..|:
Human   632 RSDSEESDSDYEEEDEEEESSRQE------TEEKILL--------DPNS--------EEVSEKDA 674

  Fly   210 SWERESDSIPGLNQAIALYKKLRSSNKGRQRDRPAPTIDLNKKYEDQPVFLKEAGLKLHPFQIEG 274
                 ...|....|.:.....::.|.:|.|........ ::::.|.|...|....|| | :|::|
Human   675 -----KQIIETAKQDVDDEYSMQYSARGSQSYYTVAHA-ISERVEKQSALLINGTLK-H-YQLQG 731

  Fly   275 VSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWA 339
            :.|:...:...:..||||||||||||||:..:..|.:.....||:||.||||||:||..|.:.||
Human   732 LEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWA 796

  Fly   340 PELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQY----KFNVMLTSYEFISVDAAFLGC 400
            |.:..::|.|                   |..||.:....    ||||:||:||:|..|...|..
Human   797 PSVVKISYKG-------------------TPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAK 842

  Fly   401 IDWAALVVDEAHRLRSNQSKFFRILSKYRIG-YKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQ 464
            |.|..::|||.||::::..|..::|:.:.:. .::|||||||||.|.||:.|||||....|....
Human   843 IRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCS 907

  Fly   465 TFQ----------AEFTDVSKEEQ---VKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSS 516
            ||:          .|..|:::||.   ::|||::|.|.:|||||.:|...:|.|.|::::.::|:
Human   908 TFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSA 972

  Fly   517 MQKKFYKH-----ILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYLF----PSAAEEATISP 572
            :||..|:|     ||..:....::||.|...:|:|.:|.|||.|||||:|    .|.||....| 
Human   973 LQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYS- 1036

  Fly   573 SGLYEMSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIK 637
            :|:...:.|.:||||.:||.::|.:|:|.|||||||.|||.::.::|.:.....:.|.|:||:.|
Human  1037 NGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTK 1101

  Fly   638 GDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQK 702
            .:.|...:.:||:|.|::|:|||||||||||:||..||||:|||||||||.|:||..||||:||:
Human  1102 SEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQ 1166

  Fly   703 KKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDELEDILRFGTEDLFKDGK 767
            .:|.:.|..|.|||||:|:..||:|:.:...|::.||                        .|.|
Human  1167 NEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGM------------------------FDQK 1207

  Fly   768 SEAIHYDDKAVADLLDRTNRGIEEKESWANEYLSSFKVASYATKEDHEEHDDY--------NNDA 824
            |.: |.....:..:|:......||.|...:|.|:..    .|.:|  ||.|.:        ..||
Human  1208 SSS-HERRAFLQAILEHEEENEEEDEVPDDETLNQM----IARRE--EEFDLFMRMDMDRRREDA 1265

  Fly   825 ENTDPFYWENLMGKSQPKLPKKQKKQS----QQSQV-------DVESIMGKGKRIRKEIDYSN 876
            .|.          |.:|:|.::.:..|    ..::|       :.|.|.|:|.|.|:::|||:
Human  1266 RNP----------KRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSD 1318

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Chd3NP_649111.1 PHD2_CHD_II 37..79 CDD:277007
CD_CSD 82..146 CDD:475127
CD2_tandem_CHD3-4_like 176..230 CDD:349309 9/53 (17%)
PLN03142 266..>768 CDD:215601 209/528 (40%)
SMARCA2NP_003061.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..71
Atrophin-1 <46..>450 CDD:460830
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..176
QLQ 173..207 CDD:462622
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..334
HSA 436..508 CDD:214727
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..592
BRK 589..632 CDD:462196 264/778 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..672 14/61 (23%)
DEXHc_SMARCA2 701..951 CDD:350821 97/271 (36%)
PLN03142 720..>1202 CDD:215601 207/503 (41%)
DEGH box 851..854 2/2 (100%)
SnAC 1259..1326 CDD:464219 17/70 (24%)
Bromodomain 1333..>1419 CDD:445827
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1344..1383
Bromo_SNF2L2 1382..1506 CDD:99947
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1506..1590
Blue background indicates that the domain is not in the aligned region.

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