DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and chd6

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_699360.5	Gene:	chd6 / 570753	ZFINID:	ZDB-GENE-130530-559	Length:	2953	Species:	Danio rerio

Alignment Length:	917	Identity:	324/917 - (35%)
Similarity:	487/917 - (53%)	Gaps:	128/917 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 TPGKASKD------KRPKTNAKKQKFRDEEYCKVCSDGGDLLCC--DSCPSVYHRTCLSPPLKSI 69
            |.|:.|.|      :|.....|::|:.::...||..|.|:.:..  ....:....:.|:...:..
Zfish   237 TGGEESTDPMDNTKRRSGRQVKRRKYNEDLDFKVVDDDGETIAVLGSGRIAAMSSSTLAWQAEEP 301

  Fly    70 PKGDWICPRCIPLPGKAEKILSWRWALDRSVELRTSK-GEKRREYFIKWHGMSYWHCEWIPEGQM 133
            |:.:         ....|||||.|..   :.|:...: .|:..|:::|:...||.||:|
Zfish   302 PEDE---------ANIIEKILSVRTV---NKEMAPDEPPEEMEEFYVKYRNFSYLHCKW------ 348

  Fly   134 LLHHASMVASFQRRSDMEEPSLEELDDQDGNLHERFYRYGIK-----------------PEWLLV 181
                               .:|||| ::|..:|::..|:..|                 |:::.|
Zfish   349 -------------------ATLEEL-EKDPRIHQKIKRFRNKQAQMKHIFTEPDEDLFNPDYIEV 393

  Fly   182 QRVI-----NHSEEPNGGTMYLVKWRELSYNDSSWERESDSIPGLNQAIALYKKLRSSNKGRQRD 241
            .||:     ..:|.....|.|||||..|||.:|:||.:.|..|   ..|..:::|:...:.:..:
Zfish   394 DRVLEIAITTDTETGEEVTHYLVKWCSLSYEESTWELQEDVDP---VKIKEFEELKKVPEMKHVE 455

  Fly   242 RPAP----TIDLNKKYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQT 302
            ||.|    .::.::.|.:        |.:|..:|:||::||.::|......|||||||||||||:
Zfish   456 RPLPEQWQKLEKSRDYRN--------GNQLREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQS 512

  Fly   303 VVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEV 367
            :.|||.:|..| .||||||..||||:||||||...|. |:..:.|.|.:.:|.:|.::|:...:.
Zfish   513 ITFLYEIFLMG-LRGPFLIIAPLSTITNWEREFRTWT-EMNVIVYHGSQISRQMILQYEMYHRDE 575

  Fly   368 TTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGY 432
            ....|   ..::||..::|::|.|..|...|..|:|..:|:||||||::...|....|....:.:
Zfish   576 QGNIM---SGEFKFQGVITTFEMIMADCPELKKINWRCVVIDEAHRLKNRNCKLLEGLKLMNLEH 637

  Fly   433 KLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKAD 497
            |:|||||||||::||||.|||||...:|....||..||.|:..|||||:|..||:|.||||||.|
Zfish   638 KVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDLKTEEQVKKLQAILKPMMLRRLKDD 702

  Fly   498 VLKSMPPKSEFIVRVELSSMQKKFYKHILTKNF----KALNQKGGGRVCSLLNIMMDLRKCCNHP 558
            |.|::.||.|.|:.|||:::|||:|:.||.|||    |..||.   .:.:|:|.||:||||||||
Zfish   703 VEKNLAPKEETIIEVELTNIQKKYYRAILEKNFAFLAKGANQH---NMPNLINTMMELRKCCNHP 764

  Fly   559 YLFPSAAEEATI--------SPSGLYEMSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKML 615
            ||. :.|||..:        |.:..:::.::.:|:|||.|:.|:|.:|.|..|:||:||||.:.|
Zfish   765 YLI-TGAEEKILESFRKTYSSDAADFQLQAMIQAAGKLVLIDKLLPKLLAGGHKVLVFSQMVRCL 828

  Fly   616 NVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIF 680
            ::||.:|....|.|:||||.::|:|||.|||||:...|:.|||||.||||||||||..|||.|||
Zfish   829 DILEDYLIQRRYTYERIDGRVRGNLRQAAIDRFSKVDSDRFVFLLCTRAGGLGINLTAADTCIIF 893

  Fly   681 DSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVV----RPGMGG 741
            ||||||.||:||.:|.||:||.|.|.:||.:|.||.|..:...|..|:.|...|:    |.|...
Zfish   894 DSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQDINRKGSLN 958

  Fly   742 MTTNFSKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRTNRGIEEKESWANEYLSSFKVA 806
            .....||.|:||:||.|......|.:.|...:.::.:..:|.|..:.|..:.....   |:|..|
Zfish   959 GVQQLSKMEVEDLLRKGAYGALMDEEDEGSKFCEEDIDQILQRRTQTITIQSEGKG---STFAKA 1020

  Fly   807 SYATKEDHEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQKKQSQQSQVDVESIMGKGKRIRKE 871
            |:.:..:       ..|....||.:|:.....::.::..|.:|         ||::....|:||:
Zfish  1021 SFVSSGN-------RTDISLDDPNFWQKWAKIAELEIDSKAEK---------ESLVIDTPRVRKQ 1069

  Fly   872 IDYSNQY 878
            ..:.|.:
Zfish  1070 TRHYNSF 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	6/43 (14%)
		CHROMO	85..147	CDD:237991	15/62 (24%)
		CHROMO	181..233	CDD:214605	20/56 (36%)
		SNF2_N	270..561	CDD:278600	141/294 (48%)
		DEXDc	288..440	CDD:238005	65/151 (43%)
		Helicase_C	585..700	CDD:278689	69/114 (61%)
chd6	XP_699360.5	CHROMO	309..370	CDD:237991	22/89 (25%)
		Chromo	392..445	CDD:278797	19/55 (35%)
		SNF2_N	480..767	CDD:278600	141/294 (48%)
		DEXDc	496..645	CDD:238005	65/153 (42%)
		Helicase_C	799..913	CDD:278689	69/113 (61%)
		BRK	2562..2606	CDD:197800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910