Protein Alignment Chd3 and chd6

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: XP_699360.5
• Gene: chd6 / 570753
• ZFINID: ZDB-GENE-130530-559
• Length: 2953
• Species: Danio rerio
• Alignment Length: 917
• Identity: 324/917 - (35%)
• Similarity: 487/917 - (53%)
• Gaps: 128/917 - (13%)

  Fly    13 TPGKASKD------KRPKTNAKKQKFRDEEYCKVCSDGGDLLCC--DSCPSVYHRTCLSPPLKSI 69
            |.|:.|.|      :|.....|::|:.::...||..|.|:.:..  ....:....:.|:...:..
Zfish   237 TGGEESTDPMDNTKRRSGRQVKRRKYNEDLDFKVVDDDGETIAVLGSGRIAAMSSSTLAWQAEEP 301

  Fly    70 PKGDWICPRCIPLPGKAEKILSWRWALDRSVELRTSK-GEKRREYFIKWHGMSYWHCEWIPEGQM 133
            |:.:         ....|||||.|..   :.|:...: .|:..|:::|:...||.||:|
Zfish   302 PEDE---------ANIIEKILSVRTV---NKEMAPDEPPEEMEEFYVKYRNFSYLHCKW------ 348

  Fly   134 LLHHASMVASFQRRSDMEEPSLEELDDQDGNLHERFYRYGIK-----------------PEWLLV 181
                               .:|||| ::|..:|::..|:..|                 |:::.|
Zfish   349 -------------------ATLEEL-EKDPRIHQKIKRFRNKQAQMKHIFTEPDEDLFNPDYIEV 393

  Fly   182 QRVI-----NHSEEPNGGTMYLVKWRELSYNDSSWERESDSIPGLNQAIALYKKLRSSNKGRQRD 241
            .||:     ..:|.....|.|||||..|||.:|:||.:.|..|   ..|..:::|:...:.:..:
Zfish   394 DRVLEIAITTDTETGEEVTHYLVKWCSLSYEESTWELQEDVDP---VKIKEFEELKKVPEMKHVE 455

  Fly   242 RPAP----TIDLNKKYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQT 302
            ||.|    .::.::.|.:        |.:|..:|:||::||.::|......|||||||||||||:
Zfish   456 RPLPEQWQKLEKSRDYRN--------GNQLREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQS 512

  Fly   303 VVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEV 367
            :.|||.:|..| .||||||..||||:||||||...|. |:..:.|.|.:.:|.:|.::|:...:.
Zfish   513 ITFLYEIFLMG-LRGPFLIIAPLSTITNWEREFRTWT-EMNVIVYHGSQISRQMILQYEMYHRDE 575

  Fly   368 TTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGY 432
            ....|   ..::||..::|::|.|..|...|..|:|..:|:||||||::...|....|....:.:
Zfish   576 QGNIM---SGEFKFQGVITTFEMIMADCPELKKINWRCVVIDEAHRLKNRNCKLLEGLKLMNLEH 637

  Fly   433 KLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKAD 497
            |:|||||||||::||||.|||||...:|....||..||.|:..|||||:|..||:|.||||||.|
Zfish   638 KVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDLKTEEQVKKLQAILKPMMLRRLKDD 702

  Fly   498 VLKSMPPKSEFIVRVELSSMQKKFYKHILTKNF----KALNQKGGGRVCSLLNIMMDLRKCCNHP 558
            |.|::.||.|.|:.|||:::|||:|:.||.|||    |..||.   .:.:|:|.||:||||||||
Zfish   703 VEKNLAPKEETIIEVELTNIQKKYYRAILEKNFAFLAKGANQH---NMPNLINTMMELRKCCNHP 764

  Fly   559 YLFPSAAEEATI--------SPSGLYEMSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKML 615
            ||. :.|||..:        |.:..:::.::.:|:|||.|:.|:|.:|.|..|:||:||||.:.|
Zfish   765 YLI-TGAEEKILESFRKTYSSDAADFQLQAMIQAAGKLVLIDKLLPKLLAGGHKVLVFSQMVRCL 828

  Fly   616 NVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIF 680
            ::||.:|....|.|:||||.::|:|||.|||||:...|:.|||||.||||||||||..|||.|||
Zfish   829 DILEDYLIQRRYTYERIDGRVRGNLRQAAIDRFSKVDSDRFVFLLCTRAGGLGINLTAADTCIIF 893

  Fly   681 DSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVV----RPGMGG 741
            ||||||.||:||.:|.||:||.|.|.:||.:|.||.|..:...|..|:.|...|:    |.|...
Zfish   894 DSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQDINRKGSLN 958

  Fly   742 MTTNFSKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRTNRGIEEKESWANEYLSSFKVA 806
            .....||.|:||:||.|......|.:.|...:.::.:..:|.|..:.|..:.....   |:|..|
Zfish   959 GVQQLSKMEVEDLLRKGAYGALMDEEDEGSKFCEEDIDQILQRRTQTITIQSEGKG---STFAKA 1020

  Fly   807 SYATKEDHEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQKKQSQQSQVDVESIMGKGKRIRKE 871
            |:.:..:       ..|....||.:|:.....::.::..|.:|         ||::....|:||:
Zfish  1021 SFVSSGN-------RTDISLDDPNFWQKWAKIAELEIDSKAEK---------ESLVIDTPRVRKQ 1069

  Fly   872 IDYSNQY 878
            ..:.|.:
Zfish  1070 TRHYNSF 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	6/43 (14%)
		CD_CSD	82..146	CDD:475127	15/64 (23%)
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	20/58 (34%)
		PLN03142	266..>768	CDD:215601	242/517 (47%)
chd6	XP_699360.5	CD1_tandem_CHD5-9_like	303..369	CDD:349315	22/103 (21%)
		CD2_tandem_CHD5-9_like	388..446	CDD:349310	20/60 (33%)
		PLN03142	476..>1077	CDD:215601	262/629 (42%)
		DEXHc_CHD6	477..698	CDD:350816	103/225 (46%)
		BRK	2561..2604	CDD:462196
		PHA03255	2716..>2789	CDD:165513