Protein Alignment Chd3 and chd7

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: XP_697956.4
• Gene: chd7 / 569471
• ZFINID: ZDB-GENE-070912-179
• Length: 3140
• Species: Danio rerio
• Alignment Length: 922
• Identity: 331/922 - (35%)
• Similarity: 496/922 - (53%)
• Gaps: 126/922 - (13%)

  Fly     3 SKRGADPD-----WKTPGKASKD--------KRPKTNAKKQKF-RDEEYCKVCSDGGDLLCCDSC 53
            :||..:|.     .|||.::.::        :|.....|:::: .|.|:.....|.||.......
Zfish   765 AKRKREPSVTSDVEKTPPQSPEEEDDDGVQKRRSSRQVKRKRYTEDLEFRISDDDDGDDSAGPKS 829

  Fly    54 PSVYHRTCLSPPLKSIPKGDWICPRCIPLPGKAEKILSWRWALDRSVELRTSKGEKRREYFIKWH 118
            |:...:       :.:|..:.      |:   .|||:..|..   ..||.:.:..:..|:::|:.
Zfish   830 PTTSEQ-------QELPDAEG------PV---VEKIMGMRMG---KKELASGEEIEVEEFYVKFK 875

  Fly   119 GMSYWHCEW--IPEGQMLLHHASMVASFQRRSDMEEPSLEELDDQDGNLHERFYRYGIKPEWLLV 181
            |.||.||.|  |.|.:........:..|:.:..: ...:.|:||:..|           |:::.|
Zfish   876 GFSYLHCRWADIEELEKDKRIQQKIKRFRAKQAL-STFVTEMDDEPFN-----------PDYVEV 928

  Fly   182 QRVINHSE--EPNGG--TMYLVKWRELSYNDSSWERESDSIPGLNQA-IALYKKLRSSNKGRQRD 241
            .||::.||  :.||.  |:|||||..|.|.||:||.::|    ::|. |..::::.:.....:|.
Zfish   929 DRVLDVSESTDENGELVTLYLVKWCSLPYEDSTWELKAD----IDQVKIEEFERVMAREPQLKRV 989

  Fly   242 RPAPTIDLNKKYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFL 306
            ...||.|..|....:.  .|.|. .|..:|:|||:||.::|......|||||||||||||::.||
Zfish   990 ERPPTSDWQKSESSRE--YKNAN-ALREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFL 1051

  Fly   307 YSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKT 371
            |.::.:| ..||||:..||||:.|||||...|. ||..|.|.|.:.:|..|:.:|:.:.:...:.
Zfish  1052 YEIYLKG-IHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVYHGSQASRKTIQAYEMYYRDTQGRI 1114

  Fly   372 MRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLL 436
            ::   ..|||:.::|::|.|..|...|..:.|..:::||||||::...|....|....:.:|:||
Zfish  1115 IK---GAYKFHAVITTFEMILTDCPELRNVPWRCVIIDEAHRLKNRNCKLLEGLKMMDMEHKVLL 1176

  Fly   437 TGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKS 501
            |||||||.:||||.|||||...:|....||..||.|:..||||::|..||:|.||||||.||.|:
Zfish  1177 TGTPLQNTVEELFSLLNFLEPDRFPSESTFMQEFGDLKTEEQVQKLQGILKPMMLRRLKEDVEKN 1241

  Fly   502 MPPKSEFIVRVELSSMQKKFYKHILTKNFKALNQK---------GGGRVCSLLNIMMDLRKCCNH 557
            :.||.|.|:.|||:::|||:|:.||.|||..|::.         ||..|.:|||.||:|||||||
Zfish  1242 LAPKEETIIEVELTNVQKKYYRAILEKNFAFLSKSGAGGGSGGGGGSNVPNLLNTMMELRKCCNH 1306

  Fly   558 PYLFPSAAEEATI----------SPSGLYEMSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMT 612
            |||. :.|||..:          .|.  :.:.::.:|:|||.|:.|:|.:|||..||||:||||.
Zfish  1307 PYLI-NGAEEKIMEEFRETHPLDQPE--FHLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMV 1368

  Fly   613 KMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTV 677
            :.|::||.:|....|.|:||||.::|:|||.|||||:.|.|:.|||||.||||||||||..|||.
Zfish  1369 RCLDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSRPDSDRFVFLLCTRAGGLGINLTAADTC 1433

  Fly   678 IIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGM 742
            |||||||||.||:||.:|.||:||.|.|.|||.:|.||.|..:...|..|:.|...|:: .|.|.
Zfish  1434 IIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQ-SMSGR 1497

  Fly   743 ------TTNFSKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRTNRGIE-EKESWANEYL 800
                  ....||.|:||:||.|......:.:.|...:.::.:..:|.|..:.|. |.|...
Zfish  1498 ENAANGVQQLSKKEIEDLLRKGAYGALMEEEDEGSKFCEEDIDQILQRRTQTITIESEGKG---- 1558

  Fly   801 SSFKVASYATKEDHEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQKKQSQQSQVDVESIMGKG 865
            |:|..||:.:..:       ..|....||.:|:               |.::::::|:::|.|:.
Zfish  1559 STFAKASFVSAGN-------RTDISLEDPDFWQ---------------KWAKKAELDLDAINGRN 1601

  Fly   866 K------RIRKE 871
            .      |:||:
Zfish  1602 NLVIDTPRVRKQ 1613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	5/41 (12%)
		CD_CSD	82..146	CDD:475127	17/65 (26%)
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	23/58 (40%)
		PLN03142	266..>768	CDD:215601	243/526 (46%)
chd7	XP_697956.4	Med15	<30..>317	CDD:312941
		PAT1	<258..>399	CDD:401645
		Atrophin-1	362..>608	CDD:460830
		CD1_tandem_CHD5-9_like	840..905	CDD:349315	18/76 (24%)
		CD2_tandem_CHD5-9_like	923..980	CDD:349310	23/60 (38%)
		PLN03142	1012..>1618	CDD:215601	264/637 (41%)
		BRK	2741..2784	CDD:462196